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Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Additionally we are shipping JDP2 Antibodies (19) and JDP2 Kits (3) and many more products for this protein.
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Preeclamptic plasma induces transcription modifications involving the AP-1 (show FOSB Proteins) transcriptional regulator JDP2 in endothelial cells.
Results suggest that JDP2 is an integral component of the Nrf2-MafK complex and that it modulates antioxidant and detoxification programs by acting via the ARE.
the recruitment of multiple HDAC (show HDAC3 Proteins) members to JDP2 and ATF3 (show ATF3 Proteins) is part of their transcription repression mechanism.
The molecular mechanisms that underlie the action of JDP2 in cellular aging and replicative senescence by mediating the dissociation of polycomb repressive complexes from the p16(Ink4a)/Arf locus are discussed.
JDP2 is crucial to triggering reactivation from latency to lytic replication
JDP2 expression was downregulated in pancreatic carcinoma & this correlated with metastasis & decreased post-surgery survival.
c-Jun dimerization protein 2 inhibits cell transformation and has a role as a tumor suppressor gene
JDP2 is a cellular survival protein whose presence is necessary for normal cellular function
JDP2 acts as a repressor and could be functionally associated with HDAC3 (show HDAC3 Proteins) to inhibit CHOP (show DDIT3 Proteins) transcription
IRF2 (show IRF2 Proteins)-BP1 (show DLX4 Proteins) is a JDP2-binding protein enhancing the polyubiquitination of JDP2 and represses ATF2 (show ATF2 Proteins)-mediated transcriptional activation from a CRE-containing promoter.
High JDP2 expression in the bone marrow contributes to metastatic spread in the lung.
results suggest a negative feedback loop between JDP2 and p53 (show TP53 Proteins), and a direct link between JDP2 and a key oncogenic pathway
Tbx3 (show TBX3 Proteins) plays an important role in osteoclastogenesis at least in part by regulating CSF1 (show CSF1 Proteins)-dependent expression of JDP2.
Using transgenic mice overexpressing the AP-1 (show JUN Proteins) inhibitor JDP2, a central role of AP-1 (show JUN Proteins) in the induction of hypertrophy and apoptosis in cardiomyocytes is demonstrated.
Jdp2 transcriptionally regulates the Trp53 (show TP53 Proteins) promoter, via an atypical AP-1 (show JUN Proteins) site, and Jdp2 expression negatively regulates Trp53 (show TP53 Proteins) expression levels; a genetic mechanism for tumour formation in the context of Trp53 (show TP53 Proteins) heterozygosity
Jdp2 plays pivotal roles in in vivo bone homeostasis and host defense by regulating osteoclast and neutrophil differentiation.
JDP2 phosphorylation by JNK (show MAPK8 Proteins) results in rapid JDP2 destabilization and reduced expression levels following various cell stimuli
transcription of the gene for cyclin-A2 (show CCNA2 Proteins) appears to be a direct target of JDP2 in the suppression of cell proliferation
JDP2 expression may play a critical role in liver cancer development.
the kinase fragment of DCLK (show DCLK2 Proteins) is translocated into the nucleus upon hyperosmotic stresses and the kinase efficiently phosphorylates JDP2, a possible target in the nucleus, with the aid of histones
Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin.
Jun dimerization protein 2
, jun dimerization protein 2
, progesterone receptor co-activator
, c-Jun dimerization protein 2