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anti-Junction Plakoglobin (JUP) Antibodies

JUP encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. Additionally we are shipping Junction Plakoglobin Kits (12) and Junction Plakoglobin Proteins (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
JUP 3728 P14923
JUP 16480 Q02257
JUP 81679 Q6P0K8
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Top anti-Junction Plakoglobin Antibodies at antibodies-online.com

Showing 10 out of 197 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Chicken Mouse Un-conjugated IHC (fro), IF, IHC (p), IP, WB   50 μg Log in to see 6 to 8 Days
$357.50
Details
Cow Goat Un-conjugated EIA, WB 20 μg Log in to see 6 to 8 Days
$203.50
Details
Chicken Mouse Un-conjugated IHC (fro), IF, WB 0.1 mg Log in to see 6 to 8 Days
$313.50
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of JUP Antibody (C-term) (ABIN652942) in MCF-7 cell line lysates (35 µg/lane). JUP (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human lung carcinoma reacted with JUP Antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Mouse Un-conjugated IF, WB Immunofluorescence of monoclonal antibody to JUP on A-431 cell (antibody concentration 10 µg/mL). JUP monoclonal antibody (M01), clone 1D5 Western Blot analysis of JUP expression in A-431. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details
Chicken Mouse Un-conjugated IF, IP, IHC, WB Western blot analysis of gamma-Catenin on a HeLa lysate. Lane 1: 1:2000, lane 2: 1:4000, lane 3: 1:8000 dilution of the anti- gamma-Catenin antibody. Immunofluorescence staining of MCF7 cells. 150 μg Log in to see 5 to 6 Days
$371.97
Details
Human Rabbit Un-conjugated IF, IHC (p), WB 0.1 mg Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated ICC, IHC, ELISA, WB Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 ng), Blue: Antigen (100 ng) Figure 2: Immunofluorescence analysis of U251 cells using JUP mouse mAb (green) . Blue: DRAQ5 fluorescent DNA dye. 100 μL Log in to see 3 to 4 Days
$430.10
Details
Human Goat Un-conjugated EIA, IHC (p), WB 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated IHC (p), IP, WB Human Skin: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL Log in to see 6 to 8 Days
$500.50
Details

JUP Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-Junction Plakoglobin Antibodies

  1. Chicken Monoclonal JUP Primary Antibody for IHC (fro), IF - ABIN112236 : Akat, Mennel, Kremer, Gassler, Bleck, Kartenbeck: Molecular characterization of desmosomes in meningiomas and arachnoidal tissue. in Acta neuropathologica 2003 (PubMed)
    Show all 13 references for ABIN112236

  2. Chicken Monoclonal JUP Primary Antibody for IF, IP - ABIN967860 : Mary, Charrasse, Meriane, Comunale, Travo, Blangy, Gauthier-Rouvière: Biogenesis of N-cadherin-dependent cell-cell contacts in living fibroblasts is a microtubule-dependent kinesin-driven mechanism. in Molecular biology of the cell 2002 (PubMed)
    Show all 5 references for ABIN967860

  3. Human Monoclonal JUP Primary Antibody for IF, WB - ABIN395700 : Pryczynicz, Guzińska-Ustymowicz, Kemona, Czyzewska: Expression of the E-cadherin-catenin complex in patients with pancreatic ductal adenocarcinoma. in Folia histochemica et cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society 2010 (PubMed)
    Show all 5 references for ABIN395700

  4. Chicken Monoclonal JUP Primary Antibody for IHC (fro), IF - ABIN1107897 : Kolligs, Kolligs, Hajra, Hu, Tani, Cho, Fearon: gamma-catenin is regulated by the APC tumor suppressor and its oncogenic activity is distinct from that of beta-catenin. in Genes & development 2000 (PubMed)
    Show all 2 references for ABIN1107897

  5. Human Monoclonal JUP Primary Antibody for ICC, IHC - ABIN969225 : Shair, Schnegg, Raab-Traub: Epstein-Barr virus latent membrane protein-1 effects on junctional plakoglobin and induction of a cadherin switch. in Cancer research 2009 (PubMed)

  6. Human Polyclonal JUP Primary Antibody for FACS, IHC (p) - ABIN652942 : Arnemann, Spurr, Wheeler, Parker, Buxton: Chromosomal assignment of the human genes coding for the major proteins of the desmosome junction, desmoglein DGI (DSG), desmocollins DGII/III (DSC), desmoplakins DPI/II (DSP), and plakoglobin DPIII (JUP). in Genomics 1991 (PubMed)

  7. Cow (Bovine) Polyclonal JUP Primary Antibody for EIA, WB - ABIN782913 : Mainou, Everly, Raab-Traub: Unique signaling properties of CTAR1 in LMP1-mediated transformation. in Journal of virology 2007 (PubMed)

More Antibodies against Junction Plakoglobin Interaction Partners

Human Junction Plakoglobin (JUP) interaction partners

  1. Idiopathic pulmonary fibrosis lung fibroblasts expressed less Pkgb protein than control fibroblasts, but characteristic fibroblast phenotypes (adhesion, proliferation, and apoptosis) were not controlled by Pkgb expression.

  2. Immunostaining for plakoglobin might serve as an additional diagnostic marker of arrhythmogenic right ventricular cardiomyopathy in forensic pathology.

  3. Expression of gamma-catenin in NSCLC cells resulted in reduced cell migration as determined by both scratch assays and trans-well cell migration assays.

  4. Six variants of uncertain clinical significance in the PKP2 (show PKP2 Antibodies), JUP, and DSG2 (show DSG2 Antibodies) genes showed a deleterious effect on mRNA splicing, indicating these are ARVD (show TGFB3 Antibodies)/C-related pathogenic splice site mutations.

  5. gamma-catenin is a tumor suppressor in esophageal squamous cell carcinoma and may serve as a prognostic marker

  6. Immunohistochemical analysis of plakoglobin had a relatively high sensitivity and specificity in arrhythmogenic right ventricular cardiomyopathy, but could not be relied upon as a diagnostic test for ARVC.

  7. extranuclear plakoglobin has a role in controlling cell adhesion via p38MAPK-dependent regulation of keratin filament organization

  8. Plakoglobin represses SATB1 (show SATB1 Antibodies) expression and decreases in vitro proliferation, migration and invasion.

  9. Reduced immunoreactive signal of JUP at the intercalated disks can be observed in a majority of ARVD (show TGFB3 Antibodies)-C patients.

  10. redistribution of JUP from the cell membrane to the nucleus not only has the potential to serve as a diagnostic marker for ARVC but also might provide insights into its pathogenesis

Mouse (Murine) Junction Plakoglobin (JUP) interaction partners

  1. Mice with hepatic loss of the desmosomal protein gamma-Catenin are prone to cholestatic injury and chemical carcinogenesis.

  2. EMMPRIN ensures proper actomyosin-driven maturation of competent endothelial junctions by forming a molecular complex with gamma-catenin (also known as junction plakoglobin) and Nm23 (also known as NME1), a nucleoside diphosphate kinase

  3. In 2 knockin mouse models, endogenous Jup was engineered to express the Naxos-associated form of plakoglobin. Insufficiency of the truncated Naxos plakoglobin, rather than gain of function, accounted for cardiac disease manifestations.

  4. plakoglobin (Pg) in conjunction with lymphoid enhancer-binding factor 1 (Lef-1 (show LEF1 Antibodies)) differentially regulates the proximal promoters of Dsc2 (show DSC2 Antibodies) and Dsc3 (show DSC3 Antibodies)

  5. our study reveals a function for gamma-catenin in the regulation of mESC differentiation and has implications for human cancers in which gamma-catenin is mutated and/or aberrantly expressed.

  6. The data suggest novel function(s) for plakoglobin (PG) beyond the heart and define a critical threshold of PG expression that is necessary for postnatal survival.

  7. decreased plakoglobin expression increases the invasive behavior of breast cancer cells; this is the first demonstration of a functional role for plakoglobin/gamma-catenin in the metastatic process

  8. The cadherin-catenin signaling pathway was inactivated in spinal motor neurons to assess the significance of motor neuron position in motor circuit assembly; genetic inactivation of both beta- and gamma-catenin or N-cadherin (show CDH2 Antibodies), disrupts motor neuron positioning.

  9. Lack of plakoglobin in epidermis leads to keratoderma.

  10. Loss of Ncad (show CDH2 Antibodies)-binding proteins beta-catenin (show CTNNB1 Antibodies) and plakoglobin in the heart leads to gap junction remodeling and abrupt onset of spontaneous lethal ventricular arrhythmia in double knockout mice.

Zebrafish Junction Plakoglobin (JUP) interaction partners

  1. Although plakoglobin is clearly present during normal odontogenesis, the loss of plakoglobin does not influence tooth development.

  2. plakoglobin localization in the heart region shifts from adherens junctions to desmosomes during heart chamber development

  3. knockdown of plakoglobin in zebrafish results in decreased heart size, reduced heartbeat, cardiac oedema, reflux of blood between heart chambers and a twisted (show POMT2 Antibodies) tail

Junction Plakoglobin (JUP) Antigen Profile

Protein Summary

This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene\; however, not all transcripts have been fully described.

Gene names and symbols associated with JUP

  • junction plakoglobin (jup) antibody
  • junction plakoglobin (Tsp_06656) antibody
  • junction plakoglobin (JUP) antibody
  • Junction plakoglobin (plak) antibody
  • junction plakoglobin (Jup) antibody
  • junction plakoglobin (jup-b) antibody
  • junction plakoglobin a (jupa) antibody
  • ARVD12 antibody
  • cb80 antibody
  • CTNNG antibody
  • D930025P04Rik antibody
  • danPG antibody
  • DP3 antibody
  • DPIII antibody
  • fb11b06 antibody
  • jup antibody
  • PDGB antibody
  • PG antibody
  • PKGB antibody
  • plak antibody
  • wu:fb11b06 antibody

Protein level used designations for JUP

desmoplakin 3 , junction plakoglobin , Junction plakoglobin , junction plakoglobin-like , plakoglobin , catenin (cadherin-associated protein), gamma 80kDa , desmoplakin III , desmoplakin-3 , gamma-catenin , gamma-catenin (plakoglobin) , gama-catenin

GENE ID SPECIES
395011 Xenopus (Silurana) tropicalis
398496 Xenopus laevis
10909874 Trichinella spiralis
100012969 Monodelphis domestica
100194931 Salmo salar
100345709 Oryctolagus cuniculus
100440279 Pongo abelii
100564925 Anolis carolinensis
429710 Gallus gallus
3728 Homo sapiens
445543 Bos taurus
16480 Mus musculus
81679 Rattus norvegicus
480522 Canis lupus familiaris
397592 Sus scrofa
399278 Xenopus laevis
30415 Danio rerio
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