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Junction Plakoglobin Proteins (JUP)

JUP encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. Additionally we are shipping Junction Plakoglobin Antibodies (194) and Junction Plakoglobin Kits (12) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
JUP 3728 P14923
JUP 16480 Q02257
JUP 81679 Q6P0K8
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Top Junction Plakoglobin Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$4,180.00
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

JUP Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

Rat (Rattus)

Top referenced Junction Plakoglobin Proteins

  1. Human JUP Protein expressed in Wheat germ - ABIN1308342 : Cooksley-Decasper, Reiser, Thommen, Biedermann, Neidhart, Gawinecka, Cathomas, Franzeck, Wyss, Klingenberg, Nanni, Roschitzki, Matter, Wolint, Emmert, Husmann, Amann-Vesti, Maier, Gay, Lüscher et al.: Antibody phage display assisted identification of junction plakoglobin as a potential biomarker for atherosclerosis. ... in PLoS ONE 2012 (PubMed)

More Proteins for Junction Plakoglobin (JUP) Interaction Partners

Human Junction Plakoglobin (JUP) interaction partners

  1. Idiopathic pulmonary fibrosis lung fibroblasts expressed less Pkgb protein than control fibroblasts, but characteristic fibroblast phenotypes (adhesion, proliferation, and apoptosis) were not controlled by Pkgb expression.

  2. Immunostaining for plakoglobin might serve as an additional diagnostic marker of arrhythmogenic right ventricular cardiomyopathy in forensic pathology.

  3. Expression of gamma-catenin in NSCLC cells resulted in reduced cell migration as determined by both scratch assays and trans-well cell migration assays.

  4. Six variants of uncertain clinical significance in the PKP2, JUP, and DSG2 (show DSG2 Proteins) genes showed a deleterious effect on mRNA splicing, indicating these are ARVD (show TGFB3 Proteins)/C-related pathogenic splice site mutations.

  5. gamma-catenin is a tumor suppressor in esophageal squamous cell carcinoma and may serve as a prognostic marker

  6. Immunohistochemical analysis of plakoglobin had a relatively high sensitivity and specificity in arrhythmogenic right ventricular cardiomyopathy, but could not be relied upon as a diagnostic test for ARVC.

  7. extranuclear plakoglobin has a role in controlling cell adhesion via p38MAPK-dependent regulation of keratin filament organization

  8. Plakoglobin represses SATB1 (show SATB1 Proteins) expression and decreases in vitro proliferation, migration and invasion.

  9. Reduced immunoreactive signal of JUP at the intercalated disks can be observed in a majority of ARVD (show TGFB3 Proteins)-C patients.

  10. redistribution of JUP from the cell membrane to the nucleus not only has the potential to serve as a diagnostic marker for ARVC but also might provide insights into its pathogenesis

Mouse (Murine) Junction Plakoglobin (JUP) interaction partners

  1. Mice with hepatic loss of the desmosomal protein gamma-Catenin are prone to cholestatic injury and chemical carcinogenesis.

  2. EMMPRIN ensures proper actomyosin-driven maturation of competent endothelial junctions by forming a molecular complex with gamma-catenin (also known as junction plakoglobin) and Nm23 (also known as NME1), a nucleoside diphosphate kinase

  3. In 2 knockin mouse models, endogenous Jup was engineered to express the Naxos-associated form of plakoglobin. Insufficiency of the truncated Naxos plakoglobin, rather than gain of function, accounted for cardiac disease manifestations.

  4. plakoglobin (Pg) in conjunction with lymphoid enhancer-binding factor 1 (Lef-1 (show LEF1 Proteins)) differentially regulates the proximal promoters of Dsc2 (show DSC2 Proteins) and Dsc3 (show DSC3 Proteins)

  5. our study reveals a function for gamma-catenin in the regulation of mESC differentiation and has implications for human cancers in which gamma-catenin is mutated and/or aberrantly expressed.

  6. The data suggest novel function(s) for plakoglobin (PG) beyond the heart and define a critical threshold of PG expression that is necessary for postnatal survival.

  7. decreased plakoglobin expression increases the invasive behavior of breast cancer cells; this is the first demonstration of a functional role for plakoglobin/gamma-catenin in the metastatic process

  8. The cadherin-catenin signaling pathway was inactivated in spinal motor neurons to assess the significance of motor neuron position in motor circuit assembly; genetic inactivation of both beta- and gamma-catenin or N-cadherin (show CDH2 Proteins), disrupts motor neuron positioning.

  9. Lack of plakoglobin in epidermis leads to keratoderma.

  10. Loss of Ncad (show CDH2 Proteins)-binding proteins beta-catenin (show CTNNB1 Proteins) and plakoglobin in the heart leads to gap junction remodeling and abrupt onset of spontaneous lethal ventricular arrhythmia in double knockout mice.

Zebrafish Junction Plakoglobin (JUP) interaction partners

  1. Although plakoglobin is clearly present during normal odontogenesis, the loss of plakoglobin does not influence tooth development.

  2. plakoglobin localization in the heart region shifts from adherens junctions to desmosomes during heart chamber development

  3. knockdown of plakoglobin in zebrafish results in decreased heart size, reduced heartbeat, cardiac oedema, reflux of blood between heart chambers and a twisted (show POMT2 Proteins) tail

Junction Plakoglobin (JUP) Protein Profile

Protein Summary

This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene\; however, not all transcripts have been fully described.

Gene names and symbols associated with Junction Plakoglobin Proteins (JUP)

  • junction plakoglobin (jup)
  • junction plakoglobin (Tsp_06656)
  • junction plakoglobin (JUP)
  • Junction plakoglobin (plak)
  • junction plakoglobin (Jup)
  • junction plakoglobin (jup-b)
  • junction plakoglobin a (jupa)
  • ARVD12 protein
  • cb80 protein
  • CTNNG protein
  • D930025P04Rik protein
  • danPG protein
  • DP3 protein
  • DPIII protein
  • fb11b06 protein
  • jup protein
  • PDGB protein
  • PG protein
  • PKGB protein
  • plak protein
  • wu:fb11b06 protein

Protein level used designations for Junction Plakoglobin Proteins (JUP)

desmoplakin 3 , junction plakoglobin , Junction plakoglobin , junction plakoglobin-like , plakoglobin , catenin (cadherin-associated protein), gamma 80kDa , desmoplakin III , desmoplakin-3 , gamma-catenin , gamma-catenin (plakoglobin) , gama-catenin

GENE ID SPECIES
395011 Xenopus (Silurana) tropicalis
398496 Xenopus laevis
10909874 Trichinella spiralis
100012969 Monodelphis domestica
100194931 Salmo salar
100345709 Oryctolagus cuniculus
100440279 Pongo abelii
100564925 Anolis carolinensis
429710 Gallus gallus
3728 Homo sapiens
445543 Bos taurus
16480 Mus musculus
81679 Rattus norvegicus
480522 Canis lupus familiaris
397592 Sus scrofa
399278 Xenopus laevis
30415 Danio rerio
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