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JUP encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. Additionally we are shipping Junction Plakoglobin Antibodies (303) and Junction Plakoglobin Kits (13) and many more products for this protein.
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Human JUP Protein expressed in Wheat germ - ABIN1308342
Cooksley-Decasper, Reiser, Thommen, Biedermann, Neidhart, Gawinecka, Cathomas, Franzeck, Wyss, Klingenberg, Nanni, Roschitzki, Matter, Wolint, Emmert, Husmann, Amann-Vesti, Maier, Gay, Lüscher et al.: Antibody phage display assisted identification of junction plakoglobin as a potential biomarker for atherosclerosis. ... in PLoS ONE 2012
Reduced plakoglobin staining in intercalated discs of heart tissue from human arrhythmogenic right ventricular cardiomyopathy (ARVC) patients and in a murine ARVC model is caused by alterations in epitope accessibility and not by protein relocalization
Idiopathic pulmonary fibrosis lung fibroblasts expressed less Pkgb protein than control fibroblasts, but characteristic fibroblast phenotypes (adhesion, proliferation, and apoptosis) were not controlled by Pkgb expression.
Immunostaining for plakoglobin might serve as an additional diagnostic marker of arrhythmogenic right ventricular cardiomyopathy in forensic pathology.
Expression of gamma-catenin in NSCLC cells resulted in reduced cell migration as determined by both scratch assays and trans-well cell migration assays.
Six variants of uncertain clinical significance in the PKP2, JUP, and DSG2 (show DSG2 Proteins) genes showed a deleterious effect on mRNA splicing, indicating these are ARVD (show TGFB3 Proteins)/C-related pathogenic splice site mutations.
gamma-catenin is a tumor suppressor in esophageal squamous cell carcinoma and may serve as a prognostic marker
Immunohistochemical analysis of plakoglobin had a relatively high sensitivity and specificity in arrhythmogenic right ventricular cardiomyopathy, but could not be relied upon as a diagnostic test for ARVC.
extranuclear plakoglobin has a role in controlling cell adhesion via p38MAPK-dependent regulation of keratin filament organization
Plakoglobin represses SATB1 (show SATB1 Proteins) expression and decreases in vitro proliferation, migration and invasion.
Reduced immunoreactive signal of JUP at the intercalated disks can be observed in a majority of ARVD (show TGFB3 Proteins)-C patients.
Mice with hepatic loss of the desmosomal protein gamma-Catenin are prone to cholestatic injury and chemical carcinogenesis.
EMMPRIN ensures proper actomyosin-driven maturation of competent endothelial junctions by forming a molecular complex with gamma-catenin (also known as junction plakoglobin) and Nm23 (also known as NME1), a nucleoside diphosphate kinase
In 2 knockin mouse models, endogenous Jup was engineered to express the Naxos-associated form of plakoglobin. Insufficiency of the truncated Naxos plakoglobin, rather than gain of function, accounted for cardiac disease manifestations.
plakoglobin (Pg) in conjunction with lymphoid enhancer-binding factor 1 (Lef-1 (show LEF1 Proteins)) differentially regulates the proximal promoters of Dsc2 (show DSC2 Proteins) and Dsc3 (show DSC3 Proteins)
our study reveals a function for gamma-catenin in the regulation of mESC differentiation and has implications for human cancers in which gamma-catenin is mutated and/or aberrantly expressed.
The data suggest novel function(s) for plakoglobin (PG) beyond the heart and define a critical threshold of PG expression that is necessary for postnatal survival.
decreased plakoglobin expression increases the invasive behavior of breast cancer cells; this is the first demonstration of a functional role for plakoglobin/gamma-catenin in the metastatic process
The cadherin-catenin signaling pathway was inactivated in spinal motor neurons to assess the significance of motor neuron position in motor circuit assembly; genetic inactivation of both beta- and gamma-catenin or N-cadherin (show CDH2 Proteins), disrupts motor neuron positioning.
Lack of plakoglobin in epidermis leads to keratoderma.
Although plakoglobin is clearly present during normal odontogenesis, the loss of plakoglobin does not influence tooth development.
plakoglobin localization in the heart region shifts from adherens junctions to desmosomes during heart chamber development
knockdown of plakoglobin in zebrafish results in decreased heart size, reduced heartbeat, cardiac oedema, reflux of blood between heart chambers and a twisted (show POMT2 Proteins) tail
This gene encodes a major cytoplasmic protein which is the only known constituent common to submembranous plaques of both desmosomes and intermediate junctions. This protein forms distinct complexes with cadherins and desmosomal cadherins and is a member of the catenin family since it contains a distinct repeating amino acid motif called the armadillo repeat. Mutation in this gene has been associated with Naxos disease. Alternative splicing occurs in this gene\; however, not all transcripts have been fully described.
, junction plakoglobin
, Junction plakoglobin
, junction plakoglobin-like
, catenin (cadherin-associated protein), gamma 80kDa
, desmoplakin III
, gamma-catenin (plakoglobin)