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Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. Additionally we are shipping Junctophilin 1 Antibodies (19) and many more products for this protein.
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Results show that JPH1 and GDAP1 (show GDAP1 Proteins) share a common pathway and depend on each other; therefore, JPH1 can contribute to the phenotypical consequences of GDAP1 (show GDAP1 Proteins) mutations.
This study suggests that genetic variants of JPH1 may modulate the effect of smoking on carotid plaque burden.
This study demonstrates that both JP1 and JP2 (show JPH2 Proteins) in skeletal muscle undergo Ca2 (show CA2 Proteins)+-dependent proteolysis by endogenous proteases when the intracellular Ca2 (show CA2 Proteins)+ is raised within the physiological range for a sustained period
JP1 and JP2 (show JPH2 Proteins) can facilitate the assembly of DHPR (show QDPR Proteins) with other proteins of the excitation-contraction coupling machinery
JP1 gene is expressed during the whole process of cardiogenesis, while JP1 protein only appears during the early stage.
an important fraction of resting plasmalemmal Ca(2 (show CA2 Proteins)+) permeability is mediated by the Orai1 (show TMEM132A Proteins) pathway, which contributes to the control of [Ca(2 (show CA2 Proteins)+)](rest) and resting Ca(2 (show CA2 Proteins)+) stores and that this pathway is defective in JP1 KO myotubes
Skeletal muscle JP1/2 damage is significantly associated with early (0-3 days) strength deficits after performance of eccentric contractions.
Abnormal junctional membrane structures in cardiac myocytes in transgenic mice expressing junctophilin type 1.
We report a novel Junctophilin subtype, JP-4 (show JPH4 Proteins), encoded in the human (chromosome 14q11.1) and mouse (chromosome 14C1-2) genomes. JP-4 (show JPH4 Proteins) shares characteristic structural features with other JP subtypes, and is found in the brain.
Junctophilins support the Ca(2 (show CA2 Proteins)+)-mediated communication between voltage-gated Ca(2 (show CA2 Proteins)+) channels, which modulates the excitability of Purkinje cells and is fundamental to cerebellar long-term depression and motor functions.
Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. This gene is a member of the junctophilin gene family.
, junctophilin 1a
, junctophilin type 1
, junctophilin type1