You are viewing an incomplete version of our website. Please click to reload the website as full version.

anti-Junctophilin 2 (JPH2) Antibodies

Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. Additionally we are shipping Junctophilin 2 Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
JPH2 57158 Q9BR39
JPH2 59091 Q9ET78
JPH2 296345 Q2PS20
How to order from antibodies-online
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Order online
  • orders@antibodies-online.com

Top anti-Junctophilin 2 Antibodies at antibodies-online.com

Showing 10 out of 82 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Dog Rabbit Un-conjugated WB WB Suggested Anti-JPH2 Antibody Titration: 0.2-1 ug/mlPositive Control... 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated WB JPH2 Antibody (C-term) (ABIN657368) western blot analysis in ZR-75-1 c... 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of JPH2 in 293 cell lysate with this product at ... 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemistry of JPH2 in mouse skeletal muscle tissue with this... Western blot analysis of JPH2 in mouse brain tissue lysate with this p... 0.1 mg Log in to see 6 to 8 Days
$401.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB Immunohistochemistry Image: Human Heart: Formalin-Fixed, Paraffin-Embe... Immunohistochemistry Image: Human Skeletal Muscle: Formalin-Fixed, Par... 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated IHC (p), ELISA, WB Human Skeletal Muscle: Formalin-Fixed, Paraffin-Embedded (FFPE) Human Heart: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 8 to 10 Days
$551.83
Details
Human Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Rabbit Un-conjugated ELISA, WB 50 μg Log in to see 2 to 3 Days
$433.13
Details
Human Rabbit Un-conjugated ELISA, WB 100 μg Log in to see 8 to 10 Days
$522.50
Details

JPH2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality
Human , , , ,
,
Mouse (Murine) , , , ,
,
Rat (Rattus) , , , ,
,

Top referenced anti-Junctophilin 2 Antibodies

  1. Human Polyclonal JPH2 Primary Antibody for EIA, IHC (p) - ABIN500098 : Takeshima, Komazaki, Nishi, Iino, Kangawa: Junctophilins: a novel family of junctional membrane complex proteins. in Molecular cell 2000 (PubMed)
    Show all 4 references for ABIN500098

  2. Human Polyclonal JPH2 Primary Antibody for EIA, WB - ABIN500096 : Matsushita, Furukawa, Kasanuki, Nishibatake, Kurihara, Ikeda, Kamatani, Takeshima, Matsuoka: Mutation of junctophilin type 2 associated with hypertrophic cardiomyopathy. in Journal of human genetics 2007 (PubMed)
    Show all 4 references for ABIN500096

  3. Human Polyclonal JPH2 Primary Antibody for WB - ABIN657368 : Yamazaki, Yamazaki, Takeshima: New molecular components supporting ryanodine receptor-mediated Ca(2+) release: roles of junctophilin and TRIC channel in embryonic cardiomyocytes. in Pharmacology & therapeutics 2009 (PubMed)

  4. Dog (Canine) Polyclonal JPH2 Primary Antibody for WB - ABIN2784534 : Landstrom, Weisleder, Batalden, Bos, Tester, Ommen, Wehrens, Claycomb, Ko, Hwang, Pan, Ma, Ackerman: Mutations in JPH2-encoded junctophilin-2 associated with hypertrophic cardiomyopathy in humans. in Journal of molecular and cellular cardiology 2007 (PubMed)

More Antibodies against Junctophilin 2 Interaction Partners

Human Junctophilin 2 (JPH2) interaction partners

  1. Junctophilin-2 is cleaved by calpain at multiple sites, resulting in dysfunctional junctophilin-2 truncations.

  2. Our data identify a mechanistic link between microtubule densification and T-tubule remodeling and reveal microtubule-mediated JP2 redistribution as a novel mechanism for T-tubule disruption, loss of excitation-contraction coupling, and heart failure.

  3. The S101R mutation may have an effect upon the stability of the JP2 dyad organization with the potential to alter JP2-protein interactions regulating calcium cycling.

  4. This study demonstrates that both JP1 (show JPH1 Antibodies) and JP2 in skeletal muscle undergo Ca2 (show CA2 Antibodies)+-dependent proteolysis by endogenous proteases when the intracellular Ca2 (show CA2 Antibodies)+ is raised within the physiological range for a sustained period

  5. Hypertrophy in skeletal myotubes induced by junctophilin-2 mutant, Y141H, involves an increase in store-operated Ca2 (show CA2 Antibodies)+ entry via Orai1 (show ORAI1 Antibodies).

  6. JP1 (show JPH1 Antibodies) and JP2 can facilitate the assembly of DHPR (show QDPR Antibodies) with other proteins of the excitation-contraction coupling machinery

  7. Loss-of-function mutations in JPH2 leads to cardiac-specific JPH2 deficiency and results in impaired cardiac contractility, causing heart failure and increased mortality.

  8. JPH2 levels are reduced in patients with hypertrophic cardiomyopathy. Reduced JPH2 expression results in reduced excitation-contraction coupling gain as well as altered Ca(2 (show CA2 Antibodies)+) homeostasis, which may be associated with prohypertrophic remodeling.

  9. S165F mutation of junctophilin 2 affects Ca2 (show CA2 Antibodies)+ signalling in skeletal muscle.

  10. this is the first report on JPH2 mutation associated with hypertrophic cardiomyopathy

Mouse (Murine) Junctophilin 2 (JPH2) interaction partners

  1. Junctophilin-2 is cleaved by calpain at multiple sites, resulting in dysfunctional junctophilin-2 truncations.

  2. overexpression of JP2 provided significantly protective benefits after pressure overload

  3. Our data identify a mechanistic link between microtubule densification and T-tubule remodeling and reveal microtubule-mediated JP2 redistribution as a novel mechanism for T-tubule disruption, loss of excitation-contraction coupling, and heart failure.

  4. JPH2 may be critical in anchoring the invaginating sarcolemma to the sarcoplasmic reticulum, thereby enabling the maturation of the transverse tubules network

  5. JP2 deficiency abolished the increase in the density of transverse elements

  6. Our data suggest a novel mechanism by which reduced JPH2-mediated stabilization of RyR2 (show RYR2 Antibodies) due to loss-of-function mutation or reduced JPH2/RyR2 (show RYR2 Antibodies) ratios can promote SR Ca(2 (show CA2 Antibodies)+) leak and atrial arrhythmias

  7. This study demonstrates that both JP1 (show JPH1 Antibodies) and JP2 in skeletal muscle undergo Ca2 (show CA2 Antibodies)+-dependent proteolysis by endogenous proteases when the intracellular Ca2 (show CA2 Antibodies)+ is raised within the physiological range for a sustained period

  8. Reducing JP2 expression in ESC-CMs (show Cd2ap Antibodies) resulted in impaired mitochondrial status due to either abnormal cellular Ca(2 (show CA2 Antibodies)+) homeostasis or disturbing of juxtaposition.

  9. Hypertrophy in skeletal myotubes induced by junctophilin-2 mutant, Y141H, involves an increase in store-operated Ca2 (show CA2 Antibodies)+ entry via Orai1 (show TMEM132A Antibodies).

  10. JP1 (show JPH1 Antibodies) and JP2 can facilitate the assembly of DHPR (show QDPR Antibodies) with other proteins of the excitation-contraction coupling machinery

Junctophilin 2 (JPH2) Antigen Profile

Protein Summary

Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. This gene is a member of the junctophilin gene family. Alternative splicing has been observed at this locus and two variants encoding distinct isoforms are described.

Gene names and symbols associated with anti-Junctophilin 2 (JPH2) Antibodies

  • junctophilin 2 (JPH2) antibody
  • junctophilin 2 (Jph2) antibody
  • 1110002E14Rik antibody
  • CMH17 antibody
  • jp antibody
  • JP-2 antibody
  • Jp2 antibody

Protein level used designations for anti-Junctophilin 2 (JPH2) Antibodies

junctophilin 2 , junctophilin-2-like , junctophilin type 2 , junctophilin-2 , JP-2

GENE ID SPECIES
469948 Pan troglodytes
770867 Gallus gallus
100461095 Pongo abelii
57158 Homo sapiens
610874 Canis lupus familiaris
100008613 Oryctolagus cuniculus
59091 Mus musculus
296345 Rattus norvegicus
614651 Bos taurus
Selected quality suppliers for anti-Junctophilin 2 (JPH2) Antibodies
Did you look for something else?