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Junctophilin 2 Proteins (JPH2)

Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. Additionally we are shipping Junctophilin 2 Antibodies (84) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
JPH2 57158 Q9BR39
JPH2 59091 Q9ET78
JPH2 296345 Q2PS20
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Top Junctophilin 2 Proteins at antibodies-online.com

Showing 6 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 59 to 64 Days
$6,052.17
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 59 to 64 Days
$8,623.45
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 39 to 44 Days
$9,248.02
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,947.17
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

JPH2 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine) ,
,
Rat (Rattus)

More Proteins for Junctophilin 2 (JPH2) Interaction Partners

Human Junctophilin 2 (JPH2) interaction partners

  1. Junctophilin-2 is cleaved by calpain at multiple sites, resulting in dysfunctional junctophilin-2 truncations.

  2. Our data identify a mechanistic link between microtubule densification and T-tubule remodeling and reveal microtubule-mediated JP2 redistribution as a novel mechanism for T-tubule disruption, loss of excitation-contraction coupling, and heart failure.

  3. The S101R mutation may have an effect upon the stability of the JP2 dyad organization with the potential to alter JP2-protein interactions regulating calcium cycling.

  4. This study demonstrates that both JP1 (show JPH1 Proteins) and JP2 in skeletal muscle undergo Ca2 (show CA2 Proteins)+-dependent proteolysis by endogenous proteases when the intracellular Ca2 (show CA2 Proteins)+ is raised within the physiological range for a sustained period

  5. Hypertrophy in skeletal myotubes induced by junctophilin-2 mutant, Y141H, involves an increase in store-operated Ca2+ entry via Orai1.

  6. JP1 (show JPH1 Proteins) and JP2 can facilitate the assembly of DHPR (show QDPR Proteins) with other proteins of the excitation-contraction coupling machinery

  7. Loss-of-function mutations in JPH2 leads to cardiac-specific JPH2 deficiency and results in impaired cardiac contractility, causing heart failure and increased mortality.

  8. JPH2 levels are reduced in patients with hypertrophic cardiomyopathy. Reduced JPH2 expression results in reduced excitation-contraction coupling gain as well as altered Ca(2 (show CA2 Proteins)+) homeostasis, which may be associated with prohypertrophic remodeling.

  9. S165F mutation of junctophilin 2 affects Ca2 (show CA2 Proteins)+ signalling in skeletal muscle.

  10. this is the first report on JPH2 mutation associated with hypertrophic cardiomyopathy

Mouse (Murine) Junctophilin 2 (JPH2) interaction partners

  1. Junctophilin-2 is cleaved by calpain at multiple sites, resulting in dysfunctional junctophilin-2 truncations.

  2. overexpression of JP2 provided significantly protective benefits after pressure overload

  3. Our data identify a mechanistic link between microtubule densification and T-tubule remodeling and reveal microtubule-mediated JP2 redistribution as a novel mechanism for T-tubule disruption, loss of excitation-contraction coupling, and heart failure.

  4. JPH2 may be critical in anchoring the invaginating sarcolemma to the sarcoplasmic reticulum, thereby enabling the maturation of the transverse tubules network

  5. JP2 deficiency abolished the increase in the density of transverse elements

  6. Our data suggest a novel mechanism by which reduced JPH2-mediated stabilization of RyR2 due to loss-of-function mutation or reduced JPH2/RyR2 ratios can promote SR Ca(2 (show CA2 Proteins)+) leak and atrial arrhythmias

  7. This study demonstrates that both JP1 (show JPH1 Proteins) and JP2 in skeletal muscle undergo Ca2 (show CA2 Proteins)+-dependent proteolysis by endogenous proteases when the intracellular Ca2 (show CA2 Proteins)+ is raised within the physiological range for a sustained period

  8. Reducing JP2 expression in ESC-CMs (show Cd2ap Proteins) resulted in impaired mitochondrial status due to either abnormal cellular Ca(2 (show CA2 Proteins)+) homeostasis or disturbing of juxtaposition.

  9. Hypertrophy in skeletal myotubes induced by junctophilin-2 mutant, Y141H, involves an increase in store-operated Ca2+ entry via Orai1.

  10. JP1 (show JPH1 Proteins) and JP2 can facilitate the assembly of DHPR (show QDPR Proteins) with other proteins of the excitation-contraction coupling machinery

Junctophilin 2 (JPH2) Protein Profile

Protein Summary

Junctional complexes between the plasma membrane and endoplasmic/sarcoplasmic reticulum are a common feature of all excitable cell types and mediate cross talk between cell surface and intracellular ion channels. The protein encoded by this gene is a component of junctional complexes and is composed of a C-terminal hydrophobic segment spanning the endoplasmic/sarcoplasmic reticulum membrane and a remaining cytoplasmic domain that shows specific affinity for the plasma membrane. This gene is a member of the junctophilin gene family. Alternative splicing has been observed at this locus and two variants encoding distinct isoforms are described.

Gene names and symbols associated with Junctophilin 2 Proteins (JPH2)

  • junctophilin 2 (JPH2)
  • junctophilin 2 (Jph2)
  • 1110002E14Rik protein
  • CMH17 protein
  • jp protein
  • JP-2 protein
  • Jp2 protein

Protein level used designations for Junctophilin 2 Proteins (JPH2)

junctophilin 2 , junctophilin-2-like , junctophilin type 2 , junctophilin-2 , JP-2

GENE ID SPECIES
469948 Pan troglodytes
770867 Gallus gallus
100461095 Pongo abelii
57158 Homo sapiens
610874 Canis lupus familiaris
100008613 Oryctolagus cuniculus
59091 Mus musculus
296345 Rattus norvegicus
614651 Bos taurus
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