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K(lysine) Acetyltransferase 5 Proteins (KAT5)

The protein encoded by KAT5 belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. Additionally we are shipping K(lysine) Acetyltransferase 5 Antibodies (156) and K(lysine) Acetyltransferase 5 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KAT5 10524 Q92993
KAT5 81601 Q8CHK4
KAT5 192218 Q99MK2
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Top K(lysine) Acetyltransferase 5 Proteins at

Showing 10 out of 12 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 21 to 26 Days
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
HOST_Sf-21 Cells Human His tag   2 μg Log in to see 5 to 8 Days
HOST_Baculovirus infected Insect Cells Human GST tag   5 μg Log in to see 10 to 12 Days
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 16 to 21 Days
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days

KAT5 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
Mouse (Murine)

Rat (Rattus)

Top referenced K(lysine) Acetyltransferase 5 Proteins

  1. Human KAT5 Protein expressed in Wheat germ - ABIN1308361 : Kurash, Lei, Shen, Marston, Granda, Fan, Wall, Li, Gaudet: Methylation of p53 by Set7/9 mediates p53 acetylation and activity in vivo. in Molecular cell 2008 (PubMed)

More Proteins for K(lysine) Acetyltransferase 5 (KAT5) Interaction Partners

Fruit Fly (Drosophila melanogaster) K(lysine) Acetyltransferase 5 (KAT5) interaction partners

  1. Heat Shock Factor recruits the dTip60 complex to the hsp70 loci in cells treated with salicylate, which triggers chromatin remodeling at these loci without transcription activation.

  2. Excess Tip60 exerts a neuroprotective role in axonal transport and functional locomotion defects in an animal model of Alzheimer's disease.

  3. a novel mechanism for Tip60 mediated sleep-wake regulation via control of axonal growth and PDF levels within the small ventrolateral neurons-encompassing neural network

  4. a functional interaction between Tip60 and APP (show APP Proteins) in mediating nervous system development and apoptotic neuronal cell death

  5. The role of Tip60 HAT activity in transcriptional control during multicellular development in vivo, was investigated.

  6. Ubiquitous dTip60 knock-down in flies was lethal, whereas knock-down in the wing imaginal disk led to developmental defects.

  7. demonstrated that the dTip60 chromatin-remodeling complex acetylates nucleosomal phospho-H2Av (show H2AFV Proteins) and exchanges it with an unmodified H2Av (show H2AFV Proteins); both the histone acetyltransferase dTip60 and the atpase Domino/p400 catalyze the exchange of phospho-H2Av (show H2AFV Proteins)

  8. TIP60 complex can promote the generation of silent chromatin.

  9. TIP60 is differentially expressed during Drosophila development, with transcript levels significantly peaking during embryogenesis, and is essential for multicellular development.

Human K(lysine) Acetyltransferase 5 (KAT5) interaction partners

  1. Data suggest the combination of histone acetyltransferase TIP60 and microRNA miR (show MLXIP Proteins)-22 as prognostic indicator of breast cancer progression.

  2. Colony-formation assays and soft agar assays show that gain of function of TIP60 or depletion of EDD1 in HPV-positive cervical cancer cells significantly inhibits cell growth in vitro

  3. We demonstrate for the first time that tumor suppressor Tip60 down-regulates cell adhesion and MT1-MMP (show MMP14 Proteins) expression and thereby invasion of glioblastoma cells

  4. TIP60 relocalization to the chromatin to acetylates histone H4K16 and prevents the binding of 53BP1 (show TP53BP1 Proteins) to its docking site.Impaired TIP60-mediated H4K16 acetylation accounts for the aberrant chromatin accumulation of 53BP1 (show TP53BP1 Proteins) and RAP80 (show UIMC1 Proteins) in Fanconi anemia (show PALB2 Proteins).

  5. Our results revealed a major role of the KAT5-ATM (show ATM Proteins) axis in protection of replicating chromatin against damage by the endogenous carcinogen FA.

  6. the acetylation-dependent NBS1 (show NBN Proteins) turnover by TIP60 on damaged chromatin restricts the dispersal of NBS1 (show NBN Proteins) foci from the sites of DNA damage.

  7. The stress-responsive gene ATF3 (show ATF3 Proteins) regulates the histone acetyltransferase Tip60 stability by promoting USP7 (show USP7 Proteins)-mediated deubiquitination of Tip60.

  8. Putative novel MYC (show MYC Proteins) interactors include components of the STAGA/KAT5 and SWI (show SMARCA1 Proteins)/SNF (show SNRPA Proteins) chromatin remodeling complexes

  9. TIP60 interacted with H3K4me3 in response to TNF-alpha (show TNF Proteins) signaling.

  10. Results establish that Tip60-T158 phosphorylation by p38 (show CRK Proteins) plays an essential role in stimulating Tip60 activity required for inducing the p53 (show TP53 Proteins)-PUMA (show BBC3 Proteins) pathway that ultimately leads to apoptosis in response to DNA damage.

Mouse (Murine) K(lysine) Acetyltransferase 5 (KAT5) interaction partners

  1. these results identify a new compaction pathway of mammalian pericentric heterochromatin relying on Tip60 that might be dependent on BRD2 (show BRD2 Proteins) recruitment by H4K12 acetylation.

  2. The expression of putative SOX4 target genes during myoblast differentiation is specifically regulated by the molecular switching of the co-activator KAT5 and the co-repressor HDAC1 on SOX4 transcriptional activation.

  3. TIP60 K327 acetylation allows TIP60 to switch binding partners. conditional knockout in Treg cells results in autoimmune disease.

  4. Allele compensation in tip60+/- mice rescues white adipose tissue function in vivo.

  5. Tip60 hyperacetylates histone H4 in Ras-transformed cells.Tip60 coordinates histone acetylation at both local and global levels to facilitate Ras-induced transformation.

  6. RGS6 (show RGS6 Proteins) suppresses Ras-induced cellular transformation by facilitating Tip60-mediated Dnmt1 (show DNMT1 Proteins) degradation and promoting apoptosis

  7. Early adipogenesis is regulated through USP7 (show USP7 Proteins)-mediated deubiquitination of the histone acetyltransferase TIP60.

  8. SLX2 interacts with synaptonemal complex central element protein 2 (SYCE2 (show SYCE2 Proteins)) and histone acetyltransferase TIP60.

  9. these results suggest that Tip60 binds with Pax6 (show PAX6 Proteins) and that this physical interaction leads to the full-transcriptional activation of Pax6 (show PAX6 Proteins) during retina development.

  10. Tip60 may function in a tumor suppressor pathway(s) to maintain adult cardiomyocytes in replicative senescence.

K(lysine) Acetyltransferase 5 (KAT5) Protein Profile

Protein Summary

The protein encoded by this gene belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction. Alternative splicing of this gene results in multiple transcript variants.

Gene names and symbols associated with KAT5

  • zgc:92510 (zgc:92510)
  • K(lysine) acetyltransferase 5 (LOC100340634)
  • CG6121 gene product from transcript CG6121-RA (Tip60)
  • histone acetyltransferase Tip60 (Tip60)
  • tip60 (AaeL_AAEL014072)
  • tip60 (Smp_053140)
  • HIV-1 tat interactive protein, homolog (human) (htatip)
  • K(lysine) acetyltransferase 5 (KAT5)
  • K(lysine) acetyltransferase 5 (Kat5)
  • 6121 protein
  • AI839539 protein
  • CG6121 protein
  • CPLA2 protein
  • DmEG0007.7 protein
  • Dmel/TIP60 protein
  • Dmel\\CG6121 protein
  • Dmel\\TIP60 protein
  • dmHAG405 protein
  • dTip60 protein
  • EG0007.7 protein
  • EG:EG0007.7 protein
  • ESA1 protein
  • Htatip protein
  • Htatip1 protein
  • im:6908768 protein
  • PLIP protein
  • TIP protein
  • Tip55 protein
  • Tip60 protein
  • wu:fb55b08 protein
  • ZC2HC5 protein
  • zgc:110752 protein

Protein level used designations for KAT5

K(lysine) acetyltransferase 5 , CG6121-PA , CG6121-PB , CG6121-PC , Tat-interactive protein , Tip60-PA , Tip60-PB , Tip60-PC , histone acetyltransferase Tip60 , tip60 , HIV-1 tat interactive protein , 60 kDa Tat-interactive protein , HIV-1 Tat interactive protein, 60kDa , K-acetyltransferase 5 , Tat interacting protein, 60kDa , cPLA(2)-interacting protein , cPLA2 interacting protein , histone acetyltransferase HTATIP , histone acetyltransferase KAT5 , HIV-1 tat interactive protein 1, 60 kDa homolog , HIV-1 tat interactive protein 1, homolog , Tat-interactive protein-60 , lysine acetyltransferase 5 , HIV-1 Tat interacting protein, 60kDa , HIV-1 Tat interactive protein 60 kD , HIV-1 Tat interactive protein, 60 kD , HIV-1 tat interactive protein, homolog , Histone acetyltransferase HTATIP

436638 Danio rerio
100340634 Oryctolagus cuniculus
31362 Drosophila melanogaster
413101 Apis mellifera
5579231 Aedes aegypti
8344228 Schistosoma mansoni
503731 Danio rerio
10524 Homo sapiens
81601 Mus musculus
483728 Canis lupus familiaris
505619 Bos taurus
192218 Rattus norvegicus
451329 Pan troglodytes
100174410 Pongo abelii
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