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The protein encoded by KAT6B is a histone acetyltransferase and component of the MOZ/MORF protein complex. Additionally we are shipping KAT6B Antibodies (24) and KAT6B Proteins (2) and many more products for this protein.
Study identified the double plant homeodomain finger (DPF) of the lysine acetyltransferase MORF as a reader of global histone H3K14 acylation.
Our findings support that phenotypes associated with typical KAT6B disease-causing variants should be referred to as 'KAT6B spectrum disorders' or 'KAT6B related disorders', rather than their current SBBYSS and GTPTS classification
Studies show that misregulation of MOZ (show MYST3 ELISA Kits)/MORF results in tumorigenesis and developmental disorders. Results also provide evidence that these 2 proteins play important role in regulating cell proliferation and stem cell maintenance. [review]
KAT6B sequence variants are being reported in the Say-Barber-Biesecker type of blepharophimosis mental retardation syndromes (SBBS) and in the more severe genitopatellar syndrome.
This study shown MYST4 to be the risk factor for attention deficit/hyperactivity disorder.
Homozygous deletions of KAT6B and the loss of its mRNA occur in SCLC cell lines and primary tumors. KAT6B loss enhances cancer growth. Restoration induces tumor suppressor-like features involving a new type of histone H3 Lys23 acetyltransferase activity.
The relationship between MYO1C (show MYO1C ELISA Kits) and KAT6B suggests that the two are interacting in chromatin remodelling for gene expression in human masseter muscle. This is the nuclear myosin1 (show DNAH8 ELISA Kits) (NM1 (show MYO1C ELISA Kits)) function of MYO1C (show MYO1C ELISA Kits).
Similar to those observed in other genetic disorders resulting from KAT6B mutations.
The study showed that markers rs11001178 (MYST4) showed weak associations.
KAT5 (show KAT5 ELISA Kits) and KAT6B regulate prostate cancer cell growth through PI3K (show PIK3CA ELISA Kits)-AKT (show AKT1 ELISA Kits) signaling.
MYST4 may contribute to important and specific acetylation events occurring during gametes and embryo development
Data indicate that Myst4, Jmjd2b, Aof1 (show KDM1B ELISA Kits) genes are regulated by H3K9me under hyperinsulinemia/hyperglycemia.
Data show that H3 acetylation by Myst4 is important for neural, craniofacial, and skeletal morphogenesis, mainly through its ability to specifically regulating the MAPK (show MAPK1 ELISA Kits) signaling pathway.
Deregulation of polyamine biosynthesis alters intrinsic histone acetyltransferase (show HAT ELISA Kits) and deacetylase activities in murine skin and tumors.
MORF4 has a role in cellular aging, and MRG15 (show MORF4L1 ELISA Kits) associates with both histone deacetylases and histone acetyl transferase (show HAT1 ELISA Kits) complexes [review]
The protein encoded by this gene is a histone acetyltransferase and component of the MOZ/MORF protein complex. In addition to its acetyltransferase activity, the encoded protein has transcriptional activation activity in its N-terminal end and transcriptional repression activity in its C-terminal end. This protein is necessary for RUNX2-dependent transcriptional activation and could be involved in brain development. Mutations have been found in patients with genitopatellar syndrome. A translocation of this gene and the CREBBP gene results in acute myeloid leukemias. Three transcript variants encoding different isoforms have been found for this gene.
histone acetyltransferase MYST4
, MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4
, MOZ-related factor
, MYST histone acetyltransferase (monocytic leukemia) 4
, histone acetyltransferase KAT6B
, histone acetyltransferase MORF
, histone acetyltransferase MOZ2
, monocytic leukemia zinc finger protein-related factor
, MYST histone acetyltransferase monocytic leukemia 4
, histone acetyltransferase querkopf
, monocytic leukemia
, protein querkopf