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Required for maintenance of euploidy during cleavage- stage embryogenesis.
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the identification of Filia as a specific regulator of genomic stability in mouse embryonic stem cells, is reported.
FILIA is part of the subcortical maternal complex (SCMC). SCMC is required for formation of the cytoplasmic F-actin meshwork that controls the central position of the spindle and ensures symmetric division.
FILIA and FILIA-N could sequester specific RNA components, supporting the critical roles of FILIA in regulation of RNA transcripts during mouse oogenesis and early embryogenesis.
High-quality diffraction data were collected from the two crystal forms of FILIA to resolutions of 1.8 and 2.2 A, respectively, using synchrotron radiation
The plasticity of the FILIA-MATER complex localization may reflect the regulative nature of preimplantation mouse development.
Results describe a subcortical maternal complex, containing Mater, Floped (show OOEP Proteins), TLE6 (show TLE6 Proteins), and Filia, that is essential for preimplantation mouse embryogenesis.
Filia is central to integrating the spatiotemporal localization of regulators that helps ensure euploidy and high-quality cell cycle progression in preimplantation mouse development.
This paper states that the ECAT1 gene is absent in rodents.
Required for maintenance of euploidy during cleavage- stage embryogenesis. Ensures proper spindle assembly by regulating the localization of AURKA via RHOA signaling and of PLK1 via a RHOA-independent process. Required for the localization of MAD2L1 to kinetochores to enable spindle assembly checkpoint function (By similarity).
ES cell associated transcript 1
, ES cell-associated transcript 1 protein
, KH domain-containing protein 3
, protein Filia