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KH Domain Containing 3, Subcortical Maternal Complex Member Proteins (KHDC3)

Required for maintenance of euploidy during cleavage- stage embryogenesis.

list all proteins Gene Name GeneID UniProt
KHDC3 300826 D3ZVV1
KHDC3 66991 Q9CWU5
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Top KHDC3 Proteins at

Showing 2 out of 2 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific pu... 1 mg Log in to see 29 to 34 Days
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days

KHDC3 Proteins by Origin and Source

Origin Expressed in Conjugate
Rat (Rattus)

Mouse (Murine)

More Proteins for KH Domain Containing 3, Subcortical Maternal Complex Member (KHDC3) Interaction Partners

Mouse (Murine) KH Domain Containing 3, Subcortical Maternal Complex Member (KHDC3) interaction partners

  1. the identification of Filia as a specific regulator of genomic stability in mouse embryonic stem cells, is reported.

  2. FILIA is part of the subcortical maternal complex (SCMC). SCMC is required for formation of the cytoplasmic F-actin meshwork that controls the central position of the spindle and ensures symmetric division.

  3. FILIA and FILIA-N could sequester specific RNA components, supporting the critical roles of FILIA in regulation of RNA transcripts during mouse oogenesis and early embryogenesis.

  4. High-quality diffraction data were collected from the two crystal forms of FILIA to resolutions of 1.8 and 2.2 A, respectively, using synchrotron radiation

  5. The plasticity of the FILIA-MATER complex localization may reflect the regulative nature of preimplantation mouse development.

  6. Results describe a subcortical maternal complex, containing Mater, Floped (show OOEP Proteins), TLE6 (show TLE6 Proteins), and Filia, that is essential for preimplantation mouse embryogenesis.

  7. Filia is central to integrating the spatiotemporal localization of regulators that helps ensure euploidy and high-quality cell cycle progression in preimplantation mouse development.

  8. This paper states that the ECAT1 gene is absent in rodents.

KHDC3 Protein Profile

Protein Summary

Required for maintenance of euploidy during cleavage- stage embryogenesis. Ensures proper spindle assembly by regulating the localization of AURKA via RHOA signaling and of PLK1 via a RHOA-independent process. Required for the localization of MAD2L1 to kinetochores to enable spindle assembly checkpoint function (By similarity).

Gene names and symbols associated with KHDC3

  • KH domain containing 3, subcortical maternal complex member (Khdc3)
  • 2410004A20Rik protein
  • AI467128 protein
  • Ecat1 protein
  • FILIA protein
  • OEEP48 protein
  • RGD1311617 protein

Protein level used designations for KHDC3

ES cell associated transcript 1 , ES cell-associated transcript 1 protein , KH domain-containing protein 3 , protein Filia

300826 Rattus norvegicus
66991 Mus musculus
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