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The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997 [PubMed 9136930]\; Gherzi et al., 2004 [PubMed 15175153]).[supplied by OMIM, Apr 2010].. Additionally we are shipping KHSRP Antibodies (69) and KHSRP Kits (5) and many more products for this protein.
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TGF-beta (show TGFB1 Proteins)-induced KHSRP silencing is central in a pathway leading to gene-expression.
propose KSRP phosphorylation as a link between phosphatidylinositol 3-kinase-AKT (show AKT1 Proteins) signaling and beta-catenin (show CTNNB1 Proteins) accumulation
mechanistic evidence that KSRP promotes the down-regulation of Spry4 (show SPRY4 Proteins) by a previously unidentified mechanism, i.e. post-transcriptional mRNA regulation.
The interaction between the KLHL12 (show KLHL12 Proteins) and the C-terminal domain of KHSRP contributed to KHSRP ubiquitination, leading to downregulation of enterovirus internal ribosome entry sites-mediated translation in infected cells.
The miRNA biogenesis factors, DDX17 (show DDX17 Proteins) and KHSRP, regulate the protein level of Ago2 (show EIF2C2 Proteins) in human cells.
Results show that KHSRP protein is highly expressed in osteosarcoma cells and provide evidence for its important roles in regulatory controls of osteosarcoma pathogenesis.
High FBP2 expression is associated with doxorubicin resistance in breast cancer .
Further analyses indicated that KHSRP was involved in miR-26a maturation and inhibited the expression of PTEN in small cell lung cancer cells
The expression of KSRP in liver epithelial cells controlled by mir (show MLXIP Proteins)-27b.
Khsrp as a highly regulated RBP (show RBP4 Proteins) in response to genotoxic stress.
IFN-gamma (show IFNG Proteins) production was increased in spleen cells of KSRP(-/-) mice.
Resveratrol causes a shift from the mesenchymal-specific forms of these factors to the respective epithelial forms and increases the expression of the RNA-binding proteins KHSRP and hnRNPA1 (show HNRNPA1 Proteins).
KSRP is critical in governing hepatic lipid metabolism through controlling Per2 (show PER2 Proteins) expression
KSRP modulation of GAP-43 (show GAP43 Proteins) mRNA stability restricts axonal outgrowth in embryonic hippocampal neurons.
This study reveals the in vivo function of KSRP in controlling brown-like transformation of subcutaneous/inguinal white adipose tissue through post-transcriptional regulation of miR (show MLXIP Proteins)-150 expression.
This study reveals a novel in vivo function of KSRP in controlling adipose lipolysis through posttranscriptional regulation of miR (show MLXIP Proteins)-145 expression.
KSRP is required to maintain P19 cells in undifferentiated state and that its inactivation can orient cells towards neural differentiation.
Our results outline a critical role for KSRP in regulating pro-inflammatory mediators and have implications for a wide range of CNS inflammatory and autoimmune diseases.
We have identified a post-transcriptional regulatory network active during mouse pituitary development in which the expression of the hormone alphaGSU (show CGA Proteins) is increased by let7b/c through downregulation of KSRP
data suggest that miR (show MLXIP Proteins)-27b targets KSRP and modulates iNOS (show NOS2 Proteins) mRNA stability following C. parvum infection, a process that may be relevant to the regulation of epithelial anti-microbial defense in general
The KHSRP gene encodes a multifunctional RNA-binding protein implicated in a variety of cellular processes, including transcription, alternative pre-mRNA splicing, and mRNA localization (Min et al., 1997
KH-type splicing regulatory protein
, KH-type splicing regulatory protein (FUSE binding protein 2)
, FUSE binding protein 2
, far upstream element-binding protein 2
, FUSE-binding protein 2
, KH type-splicing regulatory protein
, MAP2 RNA trans-acting protein 1
, MAP2 RNA trans-acting protein MARTA1
, zipcode-binding protein 2