KIAA1967 Proteins (KIAA1967)

Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions.

list all proteins Gene Name GeneID UniProt
Human KIAA1967 KIAA1967 57805 Q8N163
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More Proteins for KIAA1967 Interaction Partners

Human KIAA1967 interaction partners

  1. Long non-coding RNA MALAT1 interacts with DBC1 (show DBC1 Proteins) to regulate p53 (show TP53 Proteins) acetylation.

  2. Data suggest that DBC1 (show DBC1 Proteins) has a dual function in regulating beta-catenin (show CTNNB1 Proteins)-PROX1 (show PROX1 Proteins) signaling axis: as a coactivator for both beta-catenin (show CTNNB1 Proteins) and PROX1 (show PROX1 Proteins).

  3. important role for CCAR2 in maintaining cell cycle progression and promoting squamous cell carcinoma (SCC (show CYP11A1 Proteins)) tumorigenesis.

  4. Data show that the interaction between cell cycle and apoptosis regulator 2 (CCAR2) and heat shock protein 60 (Hsp60 (show HSPD1 Proteins)) increases in the presence of rotenone.

  5. Results found transcriptional levels of DBC1 (show DBC1 Proteins),a negative regulator of HDAC3 (show HDAC3 Proteins) significantly reduced in type 2 diabetes mellitus patients.

  6. DBC1 (show DBC1 Proteins) protein could be a prognostic marker of shorter recurrence-free survival in hepatocellular carcinoma patients after hepatectomy and human hepatocarcinogenesis was a multistep process accompanied by a stepwise increase in high DBC1 (show DBC1 Proteins) expression from low-grade dysplastic nodules, through high-grade dysplastic nodules, to hepatocellular carcinoma.

  7. Results suggest that DBC1 (show DBC1 Proteins) is integral to the maintenance of the circadian molecular clock.

  8. loss of DBC1 (show DBC1 Proteins) expression plays a role in tumorigenesis and tumor progression in gallbladder carcinoma.

  9. Proteosome-mediated degradation and poly-ubiquitination of AR were increased with the knock-down of DBC1 (show DBC1 Proteins).

  10. The results suggest that the PP4 (show ANXA5 Proteins)-mediated dephosphorylation of DBC1 (show DBC1 Proteins) is necessary for efficient damage responses in cells.

Cow (Bovine) KIAA1967 interaction partners

  1. expression of DBC1 (show DBC1 Proteins)-A was extraordinary high in calves adipose tissue, which implicated its potential key role in regulating calve adipocyte development

KIAA1967 Protein Profile

Protein Summary

Core component of the DBIRD complex, a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions. Inhibits SIRT1 deacetylase activity leading to increasing levels of p53/TP53 acetylation and p53-mediated apoptosis. Inhibits SUV39H1 methyltransferase activity.

Gene names and symbols associated with KIAA1967 Proteins (KIAA1967)

  • cell cycle and apoptosis regulator 2 (CCAR2)
  • KIAA1967 ortholog (KIAA1967)
  • cell division cycle and apoptosis regulator 1 (CCAR1)
  • KIAA1967 (KIAA1967)
  • CCAR1 protein
  • DBC-1 protein
  • DBC1 protein
  • DKFZp469H1413 protein
  • KIAA1967 protein
  • NET35 protein
  • p30 DBC protein
  • p30DBC protein

Protein level used designations for KIAA1967 Proteins (KIAA1967)

DBIRD complex subunit KIAA1967 , deleted in breast cancer 1 , p30 DBC protein , protein KIAA1967 homolog , cell division cycle and apoptosis regulator 1 , protein KIAA1967 , KIAA1967

GENE ID SPECIES
57805 Homo sapiens
507114 Bos taurus
693585 Macaca mulatta
100155718 Sus scrofa
100173017 Pongo abelii
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