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KIN, Antigenic Determinant of RecA Protein Homolog (Mouse) (KIN) ELISA Kits

The protein encoded by KIN is a nuclear protein that forms intranuclear foci during proliferation and is redistributed in the nucleoplasm during the cell cycle. Additionally we are shipping KIN Antibodies (25) and KIN Proteins (6) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Mouse KIN KIN 16588 Q8K339
Anti-Rat KIN KIN 689197  
Anti-Human KIN KIN 22944 O60870
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More ELISA Kits for KIN Interaction Partners

Mouse (Murine) KIN, Antigenic Determinant of RecA Protein Homolog (Mouse) (KIN) interaction partners

  1. identification of KIN17 as a component of the human spliceosome indicate that this protein may participate in RNA processing

Human KIN, Antigenic Determinant of RecA Protein Homolog (Mouse) (KIN) interaction partners

  1. overexpression of KIN rendered colorectal cancer cells enriching cancer stem cell (CSC) markers and CSC phenotype, and silencing KIN reduced CSC markers and CSC phenotype.

  2. Trimethylated at Lys-135 by METTL22

  3. up-regulation of kin17 is strongly associated with cellular proliferation, DNA replication, DNA damage response and breast cancer development

  4. The overexpression of human kin17 protein in vivo and the introduction of increased amounts of human kin17 protein in an in vitro assay reduced T-antigen-dependent DNA replication.

  5. results indicate the presence of functional XPA (show XPA ELISA Kits) and XPC (show XPC ELISA Kits) proteins is essential for the up-regulation of the KIN17 gene after UVC irradiation; also show that the integrity of global genome repair is required to trigger KIN17 gene expression

  6. KIN17 protein may be a component of the DNA replication machinery that participates in the cellular response to unrepaired DSBs, and an impaired KIN17 pathway leads to an increased sensitivity to ionizing radiation.

  7. Kin17 protein strongly associates in vivo with DNA fragments containing replication origins in both human HeLa and monkey CV-1 cells.

  8. C-terminal domain of human KIN17 has a basic pI, heavy-atom derivatives were obtained by soaking crystals with negatively charged ions such as tungstate & iodine. Replacement of LiCl by KI in cryosolution allowed determination of phases from iodide ions.

  9. Analysis of KIN17 structure complexed with tungstate shows structural variability within the domain

  10. Thus, human KIN17 region 51-160 might rather be involved in protein-protein interaction through its conserved surface centered on the 3(10)-helix.

KIN Antigen Profile

Antigen Summary

The protein encoded by this gene is a nuclear protein that forms intranuclear foci during proliferation and is redistributed in the nucleoplasm during the cell cycle. Short-wave ultraviolet light provokes the relocalization of the protein, suggesting its participation in the cellular response to DNA damage. Originally selected based on protein-binding with RecA antibodies, the mouse protein presents a limited similarity with a functional domain of the bacterial RecA protein, a characteristic shared by this human ortholog. Alternative splicing of this gene results in multiple transcript variants.

Gene names and symbols associated with KIN

  • antigenic determinant of rec-A protein (Kin) antibody
  • antigenic determinant of rec-A protein homolog (mouse) (Kin) antibody
  • KIN, antigenic determinant of recA protein homolog (kin) antibody
  • KIN, antigenic determinant of recA protein homolog (mouse) (KIN) antibody
  • BTCD antibody
  • KIN17 antibody

Protein level used designations for KIN

DNA/RNA-binding protein KIN17 , KIN, antigenic determinant of recA protein homolog , binding to curved DNA , HsKin17 protein

GENE ID SPECIES
16588 Mus musculus
689197 Rattus norvegicus
447303 Xenopus laevis
22944 Homo sapiens
478010 Canis lupus familiaris
519670 Bos taurus
419109 Gallus gallus
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