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Karyopherin (Importin) alpha 1 (KPNA1) ELISA Kits

The import of proteins into the nucleus is a process that involves at least 2 steps.

list all ELISA KIts Gene Name GeneID UniProt
Anti-Mouse KPNA1 KPNA1 16646 Q60960
Anti-Rat KPNA1 KPNA1 288064  
Anti-Human KPNA1 KPNA1 3838 P52292
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More ELISA Kits for KPNA1 Interaction Partners

Mouse (Murine) Karyopherin (Importin) alpha 1 (KPNA1) interaction partners

  1. mTOR (show FRAP1 ELISA Kits) and protein phosphatase 2A catalytically control the constitutive nuclear import of latent STAT1 (show STAT1 ELISA Kits) by KPNA1, which are key modulators of STAT1 (show STAT1 ELISA Kits) expression and apoptosis.

  2. KPNA1 knockdown increased myoblast proliferation.

  3. Importin alpha (show KPNA4 ELISA Kits) binding and the nuclear import of myopodin (show SYNPO2 ELISA Kits) are regulated by the serine/threonine phosphorylation-dependent binding of myopodin (show SYNPO2 ELISA Kits) to 14-3-3 (show YWHAQ ELISA Kits). These results establish a novel paradigm for the promotion of nuclear import by 14-3-3 (show YWHAQ ELISA Kits) binding.

  4. PTH1R (show PTH1R ELISA Kits) forms a complex with the transport regulatory proteins, importin alpha(1) and importin beta (show KPNB1 ELISA Kits), and nuclear PTH1R (show PTH1R ELISA Kits) is associated with the nucleoplasm

  5. Here, we show that the expression of importin-alpha (show KPNA4 ELISA Kits) subtypes is strictly regulated during neural differentiation of mouse embryonic stem (ES) cells, and that the switching of importin-alpha (show KPNA4 ELISA Kits) subtype expression is critical for neural differentiation.

  6. Absence of importin (show KPNA4 ELISA Kits) a5 during mouse development does not significantly interfere with neuronal differentiation and brain development.

Cow (Bovine) Karyopherin (Importin) alpha 1 (KPNA1) interaction partners

  1. Bovine ephemeral fever rhabdovirus alpha1 protein binds bovin importin (show KPNA4 ELISA Kits) beta1 and importin 7 (show IPO7 ELISA Kits).

Human Karyopherin (Importin) alpha 1 (KPNA1) interaction partners

  1. Suggest that KPNA2 (show KPNA2 ELISA Kits) may play a key role in the inflammation process of rheumatoid arthritis via NF-kappaB (show NFKB1 ELISA Kits) P65 (show GORASP1 ELISA Kits) signal transduction pathway.

  2. KPNA2 (show KPNA2 ELISA Kits) might play an important role in colorectal carcinogenesis and functions as a novel prognostic indicator and a potential therapeutic target for colorectal cancer.

  3. High KPNA2 (show KPNA2 ELISA Kits) expression was found to be associated with poor prognosis and resistance to hyperthermochemoradiation therapy (HCRT (show OX ELISA Kits)).

  4. RBBP4 (show RBBP4 ELISA Kits) functions as a novel regulatory factor to increase the efficiency of importin alpha (show KPNA4 ELISA Kits)/beta-mediated nuclear import

  5. A novel role of karyopherin alpha 2 in cell migration through the regulation of vimentin-pErk protein complex levels in lung cancer.

  6. High KPNA2 (show KPNA2 ELISA Kits) immunoreactivity is a predictor of bladder recurrence and poor survival in patients with upper tract urothelial carcinoma treated with radical nephroureterectomy.

  7. High KPNA2 (show KPNA2 ELISA Kits) expression is associated with osteoarthritis.

  8. Crystal structure of human importin (show KPNA4 ELISA Kits)-alpha1 (Rch1 (show KPNA2 ELISA Kits)), revealing a potential autoinhibition mode involving homodimerization.

  9. OPN (show SPP1 ELISA Kits), SPINK1 (show SPINK1 ELISA Kits), GPC3 (show GPC3 ELISA Kits) and KNPA2 were significantly over-expressed in HCC (show FAM126A ELISA Kits) tissues. These genes may be useful in developing future biomarkers and therapeutic strategies for HCC (show FAM126A ELISA Kits)

  10. This study provides further evidence for the complexity of DDR (show DDR1 ELISA Kits) mechanism in BC, and that KNPA2 has a role in the aberrant subcellular localisation of DDR (show DDR1 ELISA Kits) proteins with subsequent impaired function.

KPNA1 Antigen Profile

Antigen Summary

The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination

Gene names and symbols associated with KPNA1

  • karyopherin (importin) alpha 1 (Kpna1) antibody
  • karyopherin alpha 1 (Kpna1) antibody
  • karyopherin alpha 1 (importin alpha 5) (KPNA1) antibody
  • karyopherin alpha 2 (RAG cohort 1, importin alpha 1) (KPNA2) antibody
  • AW494490 antibody
  • IPOA1 antibody
  • IPOA5 antibody
  • mSRP1 antibody
  • NPI1 antibody
  • QIP2 antibody
  • RCH1 antibody
  • Rch2 antibody
  • SRP1alpha antibody

Protein level used designations for KPNA1

NPI-1 , RAG cohort protein 2 , SRP1-beta , importin alpha-S1 , importin subunit alpha-1 , importin subunit alpha-5 , karyopherin subunit alpha-1 , m-importin-alpha-S1 , nucleoprotein interactor 1 , importin alpha 5 , importin alpha-5 , karyopherin (importin) alpha 1 , karyopherin/importin alpha-1 , RAG cohort 1 , RAG cohort protein 1 , SRP1-alpha , importin alpha 1 , importin alpha 2 , importin subunit alpha-2 , importin-alpha-P1 , karyopherin subunit alpha-2 , pendulin

GENE ID SPECIES
16646 Mus musculus
288064 Rattus norvegicus
539679 Bos taurus
3838 Homo sapiens
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