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anti-Karyopherin (Importin) beta 1 (KPNB1) Antibodies

Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. Additionally we are shipping KPNB1 Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
KPNB1 3837 Q14974
KPNB1 16211 P70168
KPNB1 24917 P52296
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Top anti-KPNB1 Antibodies at antibodies-online.com

Showing 10 out of 80 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rat Un-conjugated WB 0.1 mg Log in to see 6 to 8 Days
$368.50
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of KPNB1 Antibody (N-term) in Y79 cell line lysates (35ug/lane). KPNB1 (arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Dog Goat Un-conjugated WB 0.1 mg Log in to see 6 to 8 Days
$379.50
Details
Human Goat Un-conjugated ELISA, WB ABIN185516 (0.03µg/ml) staining of Daudi cell lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Log in to see 4 to 5 Days
$318.20
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB Western blot analysis of KPNB1 Antibody (N-term) (ABIN390792) in Y79 cell line lysates (35 µg/lane). KPNB1 (arrow) was detected using the purified polyclonal antibody. Formalin-fixed and paraffin-embedded human brain tissue reacted with KPNB1 Antibody (N-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Dog Goat Un-conjugated EIA, IHC (p), WB 50 μg Log in to see 6 to 8 Days
$500.50
Details
Human Rabbit Un-conjugated WB WB Suggested Anti-KPNB1 AntibodyTitration: 1.0 µg/mL  Positive Control: ACHN Whole Cell  There is BioGPS gene expression data showing that KPNB1 is expressed in ACHN 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated IHC (p), ELISA, WB Human Spleen (formalin-fixed, paraffin-embedded) stained with KPNB1 antibody ABIN337256 at 5 ug/ml followed by biotinylated anti-goat IgG secondary antibody ABIN481715, alkaline phosphatase-streptavidin and chromogen. 50 μg Log in to see 8 to 10 Days
$451.00
Details
Human Mouse Un-conjugated DB 50 μg Log in to see 7 to 9 Days
$285.71
Details
Human Goat Un-conjugated ELISA, WB 0.1 mg Log in to see 2 to 3 Days
$433.13
Details

KPNB1 Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-KPNB1 Antibodies

  1. Human Monoclonal KPNB1 Primary Antibody for WB - ABIN1449199 : Sakaguchi, Miyamoto, Yoneda, Ogino, Tachibana: Generation of a rat monoclonal antibody specific for importin alpha3/Qip1. in Hybridoma and hybridomics 2003 (PubMed)
    Show all 2 references for ABIN1449199

  2. Dog (Canine) Polyclonal KPNB1 Primary Antibody for WB - ABIN374630 : Caudron, Bunt, Bastiaens, Karsenti: Spatial coordination of spindle assembly by chromosome-mediated signaling gradients. in Science (New York, N.Y.) 2005 (PubMed)

  3. Human Polyclonal KPNB1 Primary Antibody for EIA, WB - ABIN453155 : Nordgard, Johansen, Alnaes, Bucher, Syvänen, Naume, Børresen-Dale, Kristensen: Genome-wide analysis identifies 16q deletion associated with survival, molecular subtypes, mRNA expression, and germline haplotypes in breast cancer patients. in Genes, chromosomes & cancer 2008 (PubMed)

More Antibodies against KPNB1 Interaction Partners

Xenopus laevis Karyopherin (Importin) beta 1 (KPNB1) interaction partners

  1. The Importin beta-dependent nuclear import of TopBP1 (show TOPBP1 Antibodies) was required for the mitomycin C -induced Chk1 (show CHEK1 Antibodies) phosphorylation.

  2. Data show that importin-beta binds to Apc (show APC Antibodies) and negatively regulates the MT-assembly and spindle-promoting activity of Apc (show APC Antibodies) in a Ran-regulatable manner.

  3. The initial step of chromatin seeding is negatively regulated by importin beta.

Human Karyopherin (Importin) beta 1 (KPNB1) interaction partners

  1. Patients with tumors highly expressing Kpnbeta1 have poorer overall survivals. Kpnbeta1 interacts with p65 (show GORASP1 Antibodies) and enhances cell adhesion-mediated drug resistance.

  2. Collectively, these data show that KPNB1 is required for timely nuclear import of PER/CRY (show CRY2 Antibodies) in the negative feedback regulation of the circadian clock.

  3. Humanin Peptide Binds to Insulin-Like Growth Factor-Binding Protein 3 (IGFBP3 (show IGFBP3 Antibodies)) and Regulates Its Interaction with Importin-beta.

  4. RBBP4 (show RBBP4 Antibodies) functions as a novel regulatory factor to increase the efficiency of importin alpha (show KPNA4 Antibodies)/beta-mediated nuclear import

  5. High expression of KPNB1 protein is associated with hepatocellular carcinoma.

  6. Data show that cytoskeleton associated protein 5 (chTOG (show CKAP5 Antibodies)) only weakly promotes importin (show KPNA4 Antibodies)-regulated microtubule nucleation, but acts synergistically with microtubule- associated protein TPX2 (show TPX2 Antibodies).

  7. Data reveal a novel role for miR (show MLXIP Antibodies)-9 in regulation of the NFAT (show NFATC1 Antibodies) pathway by targeting KPNB1 and DYRK1B (show DYRK1B Antibodies).

  8. Data show that importin-beta (impbeta) alters the nuclear pore's permeability in a Ran-dependent manner, suggesting that impbeta is a functional component of the nuclear pore complex (NPC (show NPC1 Antibodies)).

  9. DZNep suppressed EZH2 (show EZH2 Antibodies)/miR (show MLXIP Antibodies)-30a,d/KPNB1 signaling.

  10. Importin (show KPNA4 Antibodies) beta1 mediates the translocation of NF-kappaB (show NFKB1 Antibodies) into the nuclei of myeloma cells, thereby regulating proliferation and blocking apoptosis, which provides new insights for targeted myeloma therapies.

Mouse (Murine) Karyopherin (Importin) beta 1 (KPNB1) interaction partners

  1. KPNb1 acts as a positive regulator in the NF-kappaB (show NFKB1 Antibodies) pathway to enhance palmitate-induced inflammation response.

  2. KPNB1 may play a key role in the inflammation process of rheumatoid arthritis via STAT3 (show STAT3 Antibodies) signal transduction pathway.

  3. The study revealed a regulatory role of the p97 (show EIF4G2 Antibodies)-Npl4-Ufd1 (show UFD1L Antibodies) complex in regulating a partial degradation of the NF-kappaB (show NFKB1 Antibodies) subunit p100 (show PATL2 Antibodies).

  4. Identification of a karyopherin beta1/beta2 proline-tyrosine nuclear localization signal in huntingtin (show HTT Antibodies) protein.

  5. translation of Importin (show KPNA4 Antibodies) beta1 mRNA enables separation of cytoplasmic and nuclear transport functions of importins and is required for efficient retrograde signaling in injured axons.

  6. A critical function of RanBP2 (show RANBP2 Antibodies) is to capture recycling RanGTP-importin-beta complexes at cytoplasmic fibrils to allow for adequate classical nuclear localization signal-mediated cargo import.

  7. Ap4A hydrolase (show NUDT2 Antibodies) was found to translocate into the nuclei of mast cells following immunological activation; found its immunologically dependent association with importin beta

  8. Data show that MRTF-A (show MKL1 Antibodies) contains an unusually long bipartite nuclear localisation signal embedded within the RPEL domain, that uses the importin (show KPNA4 Antibodies) (Imp (show BRAP Antibodies))alpha/beta-dependent import pathway, and that import is inhibited by G-actin (show ACTB Antibodies).

  9. results show the crystal structure of importin-beta complexed with the active form of SREBP-2 (show SREBF2 Antibodies)

  10. Results suggest that the importin alpha (show KPNA4 Antibodies)/beta system is involved in nuclear entry of mammalian clock components Cry2 (show CRY2 Antibodies) and Per2 (show PER2 Antibodies), which is indispensable to transcriptional oscillation of clock genes

KPNB1 Antigen Profile

Protein Summary

Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with KPNB1

  • importin beta-1 subunit (AFUA_1G15720) antibody
  • importin beta-1 subunit (AOR_1_1974174) antibody
  • Importin beta-1 subunit (Bm1_57540) antibody
  • importin beta-1 subunit (PMAA_065830) antibody
  • importin beta-1 subunit (AFLA_083750) antibody
  • importin beta-1 subunit (TSTA_085870) antibody
  • importin beta-1 subunit (BDBG_07509) antibody
  • importin beta-1 subunit (MCYG_00039) antibody
  • karyopherin (importin) beta 1 (kpnb1) antibody
  • importin beta 1 (LOC100533387) antibody
  • karyopherin (importin) beta 1 (KPNB1) antibody
  • karyopherin (importin) beta 1 (Kpnb1) antibody
  • AA409963 antibody
  • Afu1g15720 antibody
  • AO090005001133 antibody
  • IMB1 antibody
  • Impnb antibody
  • IPO1 antibody
  • IPOB antibody
  • NTF97 antibody

Protein level used designations for KPNB1

Importin beta-1 subunit , importin beta-1 subunit , importin beta 1 , PTAC97 , importin 1 , importin 90 , importin subunit beta-1 , importin-90 , karyopherin subunit beta-1 , nuclear factor p97 , pore targeting complex 97 kDa subunit , SCG , importin beta , Importin beta , karyopherin,beta 1 , nuclear factor P97

GENE ID SPECIES
3509962 Aspergillus fumigatus Af293
5990046 Aspergillus oryzae RIB40
6106392 Brugia malayi
7023725 Talaromyces marneffei ATCC 18224
7910816 Aspergillus flavus NRRL3357
8104552 Talaromyces stipitatus ATCC 10500
8502478 Ajellomyces dermatitidis SLH14081
9223307 Arthroderma otae CBS 113480
100137718 Xenopus laevis
100533387 Aplysia californica
3837 Homo sapiens
491042 Canis lupus familiaris
507804 Bos taurus
16211 Mus musculus
24917 Rattus norvegicus
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