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Karyopherin alpha 2 (RAG Cohort 1, Importin alpha 1) Proteins (KPNA2)

The import of proteins into the nucleus is a process that involves at least 2 steps. Additionally we are shipping KPNA2 Antibodies (104) and KPNA2 Kits (13) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KPNA2 16647 P52293
Rat KPNA2 KPNA2 85245  
KPNA2 3838 P52292
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Top KPNA2 Proteins at antibodies-online.com

Showing 8 out of 11 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag 50 μg Log in to see 7 to 8 Days
$319.00
Details
HOST_Escherichia coli (E. coli) Human His tag,T7 tag 100 μg Log in to see 11 to 13 Days
$756.80
Details
HOST_Escherichia coli (E. coli) Human His tag   50 μg Log in to see 5 Days
$522.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   50 μg Log in to see 3 to 4 Days
$382.86
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

KPNA2 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
, ,

Top referenced KPNA2 Proteins

  1. Human KPNA2 Protein expressed in Escherichia coli (E. coli) - ABIN667661 : Braem, Kas, Meyen, Debiec-Rychter, Van De Ven, Voz: Identification of a karyopherin alpha 2 recognition site in PLAG1, which functions as a nuclear localization signal. in The Journal of biological chemistry 2002 (PubMed)
    Show all 2 references for ABIN667661

  2. Human KPNA2 Protein expressed in Wheat germ - ABIN1308916 : Wang, Wang, Wang, Chen, Wu, Liang, Tsai, Chang, Yu, Yu: Importin subunit alpha-2 is identified as a potential biomarker for non-small cell lung cancer by integration of the cancer cell secretome and tissue transcriptome. in International journal of cancer. Journal international du cancer 2011 (PubMed)

More Proteins for Karyopherin alpha 2 (RAG Cohort 1, Importin alpha 1) (KPNA2) Interaction Partners

Xenopus laevis Karyopherin alpha 2 (RAG Cohort 1, Importin alpha 1) (KPNA2) interaction partners

  1. Nuclear import rates correlated with nuclear size, and varying the concentrations of two transport factors, importin alpha (show KPNA4 Proteins) and Ntf2 (show NUTF2 Proteins), was sufficient to account for nuclear scaling between the two species.

Mouse (Murine) Karyopherin alpha 2 (RAG Cohort 1, Importin alpha 1) (KPNA2) interaction partners

  1. Structure of importin-alpha (show KPNA4 Proteins) bound to a non-classical nuclear localization signal of the influenza A virus nucleoprotein has been reported.

  2. Specific interaction with the nuclear transporter (show RPAIN Proteins) importin (show KPNA4 Proteins) alpha2 can modulate paraspeckle protein 1 (show PSPC1 Proteins) delivery to nuclear paraspeckles.

  3. constitutive expression of Kpna2 during the differentiation culture of ESCs significantly impairs clock development, and KPNA2 facilitates cytoplasmic localization of PER1/

  4. a significant correlation of KPNA2 expression and tumour aggressiveness in a large variety of other solid tumour entities

  5. study reports a cell-fate determination mechanism in which importin (show KPNA4 Proteins) alpha2 negatively regulates the nuclear import of certain transcription factors to maintain embryonic stem cell properties

  6. importin alpha (show KPNA4 Proteins) binds to Nup153 (show NUP153 Proteins)

  7. results collectively reveal that nuclear-localized importin (show KPNA4 Proteins) alpha2 influences gene expression and contributes directly to cell fate outcomes including non-apoptotic cell death.

  8. Chrp, Arip3 (show PIAS2 Proteins), and Hop2 (show PSMC3IP Proteins) are binding partners of IMPalpha2 in the developmental context of germ line development.

  9. Overexpression of a dominant-negative IMPalpha2 isoform, when assessed against adjacent untransfected or IMPalpha2 transfected cells, led to both a significant reduction in endogenous Oct3/4 (show POU5F1 Proteins) protein levels and inhibition of Oct3/4 (show POU5F1 Proteins) nuclear localization.

  10. knockdown of KPNA2 decreased myotube growth.

Human Karyopherin alpha 2 (RAG Cohort 1, Importin alpha 1) (KPNA2) interaction partners

  1. Suggest that KPNA2 may play a key role in the inflammation process of rheumatoid arthritis via NF-kappaB (show NFKB1 Proteins) P65 (show GORASP1 Proteins) signal transduction pathway.

  2. KPNA2 might play an important role in colorectal carcinogenesis and functions as a novel prognostic indicator and a potential therapeutic target for colorectal cancer.

  3. High KPNA2 expression was found to be associated with poor prognosis and resistance to hyperthermochemoradiation therapy (HCRT).

  4. RBBP4 (show RBBP4 Proteins) functions as a novel regulatory factor to increase the efficiency of importin alpha (show KPNA4 Proteins)/beta-mediated nuclear import

  5. A novel role of karyopherin alpha 2 in cell migration through the regulation of vimentin-pErk protein complex levels in lung cancer.

  6. High KPNA2 immunoreactivity is a predictor of bladder recurrence and poor survival in patients with upper tract urothelial carcinoma treated with radical nephroureterectomy.

  7. High KPNA2 expression is associated with osteoarthritis.

  8. Crystal structure of human importin (show KPNA4 Proteins)-alpha1 (Rch1), revealing a potential autoinhibition mode involving homodimerization.

  9. OPN (show SPP1 Proteins), SPINK1 (show SPINK1 Proteins), GPC3 (show GPC3 Proteins) and KNPA2 were significantly over-expressed in HCC (show FAM126A Proteins) tissues. These genes may be useful in developing future biomarkers and therapeutic strategies for HCC (show FAM126A Proteins)

  10. This study provides further evidence for the complexity of DDR (show DDR1 Proteins) mechanism in BC, and that KNPA2 has a role in the aberrant subcellular localisation of DDR (show DDR1 Proteins) proteins with subsequent impaired function.

Pig (Porcine) Karyopherin alpha 2 (RAG Cohort 1, Importin alpha 1) (KPNA2) interaction partners

  1. Authors demonstrated that swine importin (show KPNA4 Proteins) alpha1 interacts with the M1 protein and transports it to the nucleus.

KPNA2 Protein Profile

Protein Summary

The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence (NLS) which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in V(D)J recombination

Gene names and symbols associated with KPNA2

  • importin subunit alpha-2 (EDI_246290)
  • importin subunit alpha-2 (EDI_335040)
  • Importin subunit alpha-2 (ima2)
  • importin alpha 1b (kpna2)
  • karyopherin (importin) alpha 2 (Kpna2)
  • karyopherin alpha 2 (Kpna2)
  • karyopherin alpha 2 (RAG cohort 1, importin alpha 1) (KPNA2)
  • karyopherin alpha 7 (importin alpha 8) (Kpna7)
  • 2410044B12Rik protein
  • AW146299 protein
  • Gm1055 protein
  • ima2 protein
  • importin protein
  • IPOA1 protein
  • PTAC58 protein
  • QIP2 protein
  • RCH1 protein
  • SRP1alpha protein

Protein level used designations for KPNA2

importin subunit alpha-2 , Importin subunit alpha-2 , karyopherin subunit alpha-2 , RAG cohort protein 1 , SRP1-alpha , importin alpha P1 , importin subunit alpha-1 , m-importin-alpha-P1 , pendulin , pore targeting complex 58 kDa subunit , karyopherin (importin) alpha 2 , nuclear import protein , RAG cohort 1 , importin alpha 1 , importin alpha 2 , importin-alpha-P1 , importin subunit alpha-8 , karyopherin subunit alpha-7 , nuclear transport receptor

GENE ID SPECIES
5881743 Entamoeba dispar SAW760
5886378 Entamoeba dispar SAW760
100195132 Salmo salar
398027 Xenopus laevis
16647 Mus musculus
85245 Rattus norvegicus
3838 Homo sapiens
480469 Canis lupus familiaris
397218 Sus scrofa
513592 Bos taurus
381686 Mus musculus
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