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The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Additionally we are shipping Karyopherin alpha 5 (Importin alpha 6) Proteins (3) and many more products for this protein.
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Chicken Polyclonal KPNA5 Primary Antibody for WB - ABIN2785826
Singh, Buscaglia, Wang, Levay, Nussenzweig, Walker, Winzeler, Fujii, Fontoura, Nussenzweig: Plasmodium circumsporozoite protein promotes the development of the liver stages of the parasite. in Cell 2007
Human Polyclonal KPNA5 Primary Antibody for EIA, IHC (p) - ABIN1449958
Moroianu: Molecular mechanisms of nuclear protein transport. in Critical reviews in eukaryotic gene expression 1997
Data shows that Importin 7 (show IPO7 Antibodies) binds many partners from ovary that alpha are involved in RNA processing, chromosome organization, and chromatin modification.
Importin (show KPNA4 Antibodies) alpha7 is a new member of the small group of maternal effect (show NLRP5 Antibodies) genes.
Overexpression of Kpna6 (show KPNA6 Antibodies) facilitates Keap1 (show KEAP1 Antibodies) nuclear import and attenuates Nrf2 (show NFE2L2 Antibodies) signaling, whereas knockdown of Kpna6 (show KPNA6 Antibodies) slows down Keap1 (show KEAP1 Antibodies) nuclear import and enhances the Nrf2 (show NFE2L2 Antibodies)-mediated adaptive response induced by oxidative stress.
BIG3 (show WDR5 Antibodies) may block the KPNAs (KPNA1 (show KPNA1 Antibodies), KPNA5, and KPNA6 (show KPNA6 Antibodies)) binding region(s) of PHB2 (show PHB2 Antibodies).
eVP24 recognizes a unique nonclassical nuclear localization signal binding site on KPNA5 that is necessary for efficient phosphoryated STAT1 (show STAT1 Antibodies) nuclear transport.
Study identified the sequences KKKRR, KKKRK, and KKRKK as the optimal sequences for binding to this site for mouse importin (show KPNA4 Antibodies)-alpha2, human importin (show KPNA4 Antibodies)-alpha1, and human importin (show KPNA4 Antibodies)-alpha5, respectively.
The transport of molecules between the nucleus and the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex (NPC) which consists of 60-100 proteins and is probably 120 million daltons in molecular size. Small molecules (up to 70 kD) can pass through the nuclear pore by nonselective diffusion\; larger molecules are transported by an active process. Most nuclear proteins contain short basic amino acid sequences known as nuclear localization signals (NLSs). KPNA5 protein belongs to the importin alpha protein family and is thought to be involved in NLS-dependent protein import into the nucleus.
, importin subunit alpha-7
, karyopherin (importin) alpha 5
, karyopherin subunit alpha-6
, importin subunit alpha-6
, karyopherin subunit alpha-5
, importin alpha 6