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KLHDC8B encodes a protein which forms a distinct beta-propeller protein structure of kelch domains allowing for protein-protein interactions. Additionally we are shipping KLHDC8B Antibodies (38) and KLHDC8B Proteins (5) and many more products for this protein.
kelch protein KLHDC8B guards against mitotic errors, centrosomal amplification, and chromosomal instability
Deficiency of KLHDC8B leads to binucleated cells, implicating its involvement in Reed-Sternberg cell formation
Depletion of KLHDC8B through RNA interference leads to an increase in binucleated cells, implicating its reduced expression in the formation of classical Hodgkin lymphoma's signature Reed-Sternberg cell.
This gene encodes a protein which forms a distinct beta-propeller protein structure of kelch domains allowing for protein-protein interactions. Mutations in this gene have been associated with Hodgkin lymphoma.
kelch domain containing 8B
, kelch domain-containing protein 8B
, kelch domain-containing protein 8B-like