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May play a role in organizing the actin cytoskeleton of the brain cells.. Additionally we are shipping Kelch-Like 2, Mayven (Drosophila) Antibodies (54) and many more products for this protein.
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Accordingly, medullary WNK4 (show WNK4 Proteins) protein levels were significantly increased in the kidneys of KLHL2(-/-) mice. KLHL2 is indeed a physiological regulator of WNK4 (show WNK4 Proteins) in vivo; however, its function might be different from that of KLHL3 (show KLHL3 Proteins) because KLHL2 mainly localized in medulla.
These results suggest that KLHL2 likely plays a role in the pathogenesis of FHHt, and aggravates the phenotype caused by mutations in CUL3 (show CUL3 Proteins) and WNK4 (show WNK4 Proteins).
This study showed that KLHL2 is involved in the physiologic regulation of the WNK signal cascade.
Co-expression of KLHL2 and Cullin3 decreases the abundance of WNK1 (show WNK1 Proteins), WNK3 and WNK4 (show WNK4 Proteins) within HEK293T cells.
Results suggest a novel E3 ubiquitin ligase (show MUL1 Proteins) function of KLHL2, with NPCD (show NPTXR Proteins) as a substrate.
overexpression of Mayven may promote tumor growth through c-Jun (show JUN Proteins) and cyclin D1 (show CCND1 Proteins)
May play a role in organizing the actin cytoskeleton of the brain cells.
kelch-like 2, Mayven
, kelch-like protein 2
, kelch-like 2, Mayven (Drosophila)
, actin-binding protein Mayven