Kelch-Like 3 (Drosophila) Proteins (KLHL3)

KLHL3 is ubiquitously expressed and encodes a full-length protein which has an N-terminal BTB domain followed by a BACK domain and six kelch-like repeats in the C-terminus. Additionally we are shipping KLHL3 Antibodies (67) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KLHL3 100503085  
KLHL3 26249 Q9UH77
Rat KLHL3 KLHL3 498697  
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Top KLHL3 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
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Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 60 Days
$7,759.50
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HOST_Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$333.33
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HOST_HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see 10 to 12 Days
$785.40
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KLHL3 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
, ,

More Proteins for Kelch-Like 3 (Drosophila) (KLHL3) Interaction Partners

Mouse (Murine) Kelch-Like 3 (Drosophila) (KLHL3) interaction partners

  1. However, phosphorylation of SPAK (show STK39 Proteins) and NCC (show SLC12A3 Proteins) at distal convoluted tubules were almost completely absent even in WNK4 (show WNK4 Proteins)(-/-)KLHL3(R528H/R528H) mice. In conclusion, increased WNK1 (show WNK1 Proteins) was unable to compensate for WNK4 (show WNK4 Proteins) deficiency and phosphorylate the NCC (show SLC12A3 Proteins), indicating that WNK4 (show WNK4 Proteins) is indispensable for the onset of PHAII.

  2. the heterozygous deletion of KLHL3 was not sufficient to cause PHAII, indicating that autosomal dominant type pseudohypoaldosteronism type II (PHAII) is caused by the dominant negative effect of mutant KLHL3.

  3. Potassium depletion stimulates NCC (show SLC12A3 Proteins) via phosphorylation and inactivation of the KLHL3 and promoting increased blood pressure.

  4. KLHL3 regulates paracellular chloride transport in the kidney by ubiquitination of claudin-8 (show CLDN8 Proteins)

  5. increased protein expression levels of WNK1 (show WNK1 Proteins) and WNK4 (show WNK4 Proteins) kinases cause PHAII by KLHL3 R528H mutation due to impaired KLHL3-Cullin3-mediated ubiquitination.

Human Kelch-Like 3 (Drosophila) (KLHL3) interaction partners

  1. Mutation in the KLHL3 gene is associated with Gordon syndrome.

  2. The results demonstrate that Hcy decreases the expression of cMyBP-C through a KLHL3-mediated ubiquitin-proteasome pathway, and thereby influences heart development.

  3. This study provides substantial new insights into the role of phosphorylation of KLHL3 in regulating the interaction with WNK4 (show WNK4 Proteins)

  4. Data indicate that WNK lysine deficient protein kinase 4 protein (WNK4) was degraded not only by proteasomes but also by atypical protein kinase C scaffold protein p62 (p62)-kelch-like 3 protein (KLHL3)-mediated selective autophagy.

  5. Familial hyperkalemia and hypertension caused by KLHL3 mutations is accompanied by hypercalciuria as well as hyperkalemia and hypertension.

  6. Akt (show AKT1 Proteins) and PKA phosphorylated KLHL3 at S433, and phosphorylation of KLHL3 by PKA inhibited WNK4 (show WNK4 Proteins) degradation.

  7. KLHL3 is phosphorylated at serine 433 in the Kelch domain (a site frequently mutated in hypertension with hyperkalemia) by protein kinase C in cultured cells and that this phosphorylation prevents WNK4 (show WNK4 Proteins) binding and degradation.

  8. Hyperkalemic hypertension-associated cul3 (show CUL3 Proteins) mutations depletes KLHL3, preventing WNK degradation, despite increased CUL3 (show CUL3 Proteins)-mediated WNK ubiquitylation.

  9. CUL3 (show CUL3 Proteins) and KLHL3 gene products are physiologically important regulators of thiazide-sensitive distal nephron sodium chloride reabsorption.

  10. analysis of how mutations of KLHL3 show less ability to ubiquitinate WNK4 (show WNK4 Proteins) because of KLHL3's low stability and/or decreased binding to CUL3 (show CUL3 Proteins) or WNK4 (show WNK4 Proteins)

KLHL3 Protein Profile

Protein Summary

This gene is ubiquitously expressed and encodes a full-length protein which has an N-terminal BTB domain followed by a BACK domain and six kelch-like repeats in the C-terminus. These kelch-like repeats promote substrate ubiquitination of bound proteins via interaction of the BTB domain with the CUL3 (cullin 3) component of a cullin-RING E3 ubiquitin ligase (CRL) complex. Muatations in this gene cause pseudohypoaldosteronism type IID (PHA2D)\; a rare Mendelian syndrome featuring hypertension, hyperkalaemia and metabolic acidosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Gene names and symbols associated with KLHL3

  • kelch-like 3 (Drosophila) (KLHL3)
  • kelch-like 3 (Klhl3)
  • kelch-like family member 3 (KLHL3)
  • kelch-like family member 3 (Klhl3)
  • 7530408C15Rik protein
  • AI430941 protein
  • EG627648 protein
  • PHA2D protein
  • RGD1565218 protein

Protein level used designations for KLHL3

kelch-like protein 3 , kelch-like 3

GENE ID SPECIES
100174246 Pongo abelii
100503085 Mus musculus
416303 Gallus gallus
481523 Canis lupus familiaris
100519539 Sus scrofa
26249 Homo sapiens
533364 Bos taurus
498697 Rattus norvegicus
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