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KRT12 encodes the type I intermediate filament chain keratin 12, expressed in corneal epithelia. Additionally we are shipping Keratin 12 Proteins (8) and Keratin 12 Kits (2) and many more products for this protein.
Showing 10 out of 44 products:
Human Polyclonal KRT12 Primary Antibody for EIA, IHC (p) - ABIN951810
Clausen, Duncker, Grünauer-Kloevekorn: Identification of a novel mutation in the cornea specific keratin 12 gene causing Meesmann's corneal dystrophy in a German family. in Molecular vision 2010
Show all 5 references for ABIN951810
Human Polyclonal KRT12 Primary Antibody for IHC (fro), IF - ABIN401682
Langbein, Rogers, Praetzel, Cribier, Peltre, Gassler, Schweizer: Characterization of a novel human type II epithelial keratin K1b, specifically expressed in eccrine sweat glands. in The Journal of investigative dermatology 2005
Show all 2 references for ABIN401682
Combined with an effective delivery vehicle this siRNA approach represents a viable treatment option for prevention of the MECD pathology observed in K12-Leu132Pro heterozygous individuals.
We identified a novel missense mutation of the KRT12 gene in Meesmann corneal dystrophy. The in vivo confocal microscopy examinations revealed previously unreported depth-dependent ultrastructural changes in the living cornea.
Exon sequencing of KRT3 and KRT12 in six affected and eight unaffected individuals did not detect any mutations or nucleotide sequence variants in Meesmann epithelial corneal dystrophy.
The Leu132Pro missense mutation is within the helix-initiation motif of the keratin and is predicted to result in a significant structural change of the K12 protein.
The lead siRNA, with an IC(50) of thirty picomolar, showed no keratin off-target effects or activation of TLR3 (show TLR3 Antibodies) in the concentration ranges tested.
Novel missense mutation within the highly conserved helix-initiation motif of KRT12 causing Meesmann's corneal dystrophy in a German family.
Heterozygous Ala137Pro mutation in keratin 12 gene found in Japanese with Meesmann's corneal dystrophy.
A novel missense mutation (Y429C) in KRT12 lead to MCD in 2 unrelated Taiwanese families.
Mutation in the KRT12 gene is associated with Meesmann corneal dystrophy
Mutation associated with symptomatic phenotype of Meesmann's corneal dystrophy. Results in substitution of proline for arginine in helix termination motif that may disrupt normal helix, leading to dramatic structural change of keratin 12 protein.
clonal limbal stem cells randomly activate Krt12 alleles in the process of terminal differentiation in cornea
KRT12 encodes the type I intermediate filament chain keratin 12, expressed in corneal epithelia. Mutations in this gene lead to Meesmann corneal dystrophy.
, type I keratin
, keratin 12 (Meesmann corneal dystrophy)
, keratin, type I cytoskeletal 12
, Keratin, type I cytoskeletal 12 (Cytokeratin 12)
, keratin complex 1, acidic, gene 12
, keratin K12
, type I keratin KA12
, keratin, type I cytoskeletal 47 kDa
, B2 keratin