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Keratin 8 Proteins (KRT8)

KRT8 is a member of the type II keratin family clustered on the long arm of chromosome 12. Additionally we are shipping Keratin 8 Antibodies (731) and Keratin 8 Kits (15) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KRT8 3856 P05787
KRT8 16691 P11679
KRT8 25626 Q10758
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Top Keratin 8 Proteins at antibodies-online.com

Showing 10 out of 44 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human GST tag Keratin 8 (KRT8) (AA 2-483), (full length) protein (GST tag) 50 μg Log in to see 9 to 11 Days
$217.80
Details
HOST_Escherichia coli (E. coli) Human GST tag 50 μg Log in to see 21 to 26 Days
$313.50
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Bovine Cow Un-conjugated   100 μg Log in to see 7 to 9 Days
$328.21
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 7 to 9 Days
$413.21
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 μg Log in to see 2 to 3 Days
$546.00
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$668.80
Details
Yeast Mesocricetus auratus His tag   1 mg Log in to see 56 to 66 Days
$2,205.50
Details

KRT8 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
, ,
Mouse (Murine)

Rat (Rattus) ,
,

More Proteins for Keratin 8 (KRT8) Interaction Partners

Human Keratin 8 (KRT8) interaction partners

  1. K8/18 filaments provide resistance to apoptosis in granulosa cell tumor cells by impairing FAS (show FAS Proteins) expression.

  2. These metastatic tumors revealed no detectable expression of CK8/18, E-cadherin (show CDH1 Proteins), VCAM-1 (show VCAM1 Proteins), and ICAM-1 (show ICAM1 Proteins)

  3. Data show that loss of epithelial membrane protein 2 (EMP2) is involved in sphingosylphosphorylcholine (SPC (show UCN3 Proteins))-induced phosphorylation of keratin 8 (K8) via ubiquitination of protein phosphatase 2 (PP2A (show PPP2R4 Proteins)) through alpha4 phosphoprotein (show IGBP1 Proteins) by caveolin-1 (cav-1 (show CAV1 Proteins)).

  4. In human failing myocardium, where TNF-alpha (show TNF Proteins) expression is upregulated, K8/K18 (show KRT18 Proteins) were also ectopically expressed

  5. Human KRT8 variants promote acetaminophen induced hepatotoxicity in mouse models.

  6. Syndecan-1 (show SDC1 Proteins) is involved in morphogenesis of the developing tooth crown and cervical loops, andntogether with CK8 and vimentin (show VIM Proteins) in differentiation of preameloblasts and preodontoblasts.

  7. This is the first time intestinal cells have been suggested also functionally impaired by K8/K18 (show KRT18 Proteins) mutations.

  8. Study indicates that Piwil2 plays a role in Fas-mediated apoptosis and can affect p53 phosphorylation in tumor cells, revealing a novel mechanism of Piwil2 in apoptosis, and supports that Piwil2 plays an active role in tumorigenesis.

  9. An increased expression of cytokeratin 8 and weak of calponin in tunica media of saphenous vein grafts might be useful markers of unfavorable long-term prognosis in CABG patients.

  10. These data support the idea that CK8 is an important receptor for Pet on epithelial cells for starting its cytotoxic effects.

Pig (Porcine) Keratin 8 (KRT8) interaction partners

  1. This study reveals clear genetic-statistical evidence for a link of KRT8, FAF1 (show FAF1 Proteins) and PTH1R (show PTH1R Proteins) with some of leg weakness related traits in pigs.

  2. Mechanical injury of vascular smooth muscle up-regulated keratin 8.

Cow (Bovine) Keratin 8 (KRT8) interaction partners

  1. Results did not support that K8/K18 (show KRT18 Proteins) filaments influence the expression of Fas (show FAS Proteins) on the surface of luteal cells.

Mouse (Murine) Keratin 8 (KRT8) interaction partners

  1. Autoantibodies to several antigens were identified in 81% of K8-null male mice 8 mo or older. Similar autoantibodies were detected in aging K18 (show KRT18 Proteins)-null male mice that had a related liver phenotype but normal colon compared with K8-null mice

  2. The regulation of the SCFA-MCT1 (show MCTS1 Proteins)-HMGCS2 (show HMGCS2 Proteins) axis is disrupted in K8(-/-) colonocytes, suggesting a role for keratins in colonocyte energy metabolism and homeostasis.

  3. In several liver stress models epiplakin and K8 genes displayed identical expression patterns and transgenic K8 overexpression resulted in elevated hepatic epiplakin levels.

  4. In human failing myocardium, where TNF-alpha (show TNF Proteins) expression is upregulated, K8/K18 (show KRT18 Proteins) were also ectopically expressed

  5. The findings demonstrate the near complete loss of K8/K18 (show KRT18 Proteins) with concomitant high levels of vimentin (show VIM Proteins) in CT26 (show DDX53 Proteins) cells, a chemically-induced mouse colonic tumor.

  6. Directed expression of a chimeric type II keratin (show KRT80 Proteins) partially rescues keratin 5 (show KRT36 Proteins)-null mice.

  7. Keratin 8 is required for the maintenance of architectural structure in thymus epithelium.

  8. A conserved rod domain phosphotyrosine that is targeted by the phosphatase PTP1B (show PTPN1 Proteins) promotes keratin 8 protein insolubility and filament organization.

  9. K8 acetylation at Lys (show LYZ Proteins)-207, a highly conserved residue among type II keratins, is up-regulated upon hyperglycemia and down-regulated by SIRT2 (show SIRT2 Proteins).

  10. Data indicate that cyclin D1 (show CCND1 Proteins) is expressed exclusively in luminal keratin 8 immunoreactive tumor cells and is dependent on the adipose secreted hormone leptin (show LEP Proteins).

Zebrafish Keratin 8 (KRT8) interaction partners

  1. Data identify Danio rerio keratins 8/18 as the true orthologs of the human keratin pair 8/18.

Keratin 8 (KRT8) Protein Profile

Protein Summary

This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene.

Gene names and symbols associated with Keratin 8 Proteins (KRT8)

  • keratin 8 (krt8)
  • keratin 8 (KRT8)
  • keratin 8 (Krt8)
  • AA960620 protein
  • AL022697 protein
  • AU019895 protein
  • Card2 protein
  • cb186 protein
  • CK-8 protein
  • CK8 protein
  • CYK8 protein
  • CYKER protein
  • DKFZp468F2127 protein
  • DreK8 protein
  • EndoA protein
  • K2C8 protein
  • K8 protein
  • KERATIN8 protein
  • KO protein
  • Krt-2.8 protein
  • krt2-5 protein
  • krt2-8 protein
  • KRT8 protein
  • MGC69490 protein
  • sb:cb186 protein
  • wu:fa20h05 protein
  • wu:fa95h10 protein
  • wu:fb96c06 protein
  • zf-K8 protein
  • zfk8 protein

Protein level used designations for Keratin 8 Proteins (KRT8)

keratin 8 , keratin complex 2, basic, gene 5 , cytokeratin 8 , cytokeratin-8 , keratin, type II cytoskeletal 8 , type-II keratin Kb8 , CK-8 , K8 , KERA , cytokeratin-A , keratin-8 , cytokeratin endo A , keratin complex 2, basic, gene 8 , etID33550.23 , etID43142.23 , etID43142.8 , keratin, type 2, gene 8

GENE ID SPECIES
431676 Xenopus (Silurana) tropicalis
693415 Macaca mulatta
697116 Macaca mulatta
700449 Macaca mulatta
737628 Pan troglodytes
743020 Pan troglodytes
100174430 Pongo abelii
100345306 Oryctolagus cuniculus
3856 Homo sapiens
100152077 Sus scrofa
281269 Bos taurus
101110495 Ovis aries
100348891 Oryctolagus cuniculus
16691 Mus musculus
25626 Rattus norvegicus
797433 Danio rerio
380217 Xenopus laevis
426896 Gallus gallus
486513 Canis lupus familiaris
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