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KRT8 is a member of the type II keratin family clustered on the long arm of chromosome 12. Additionally we are shipping Keratin 8 Proteins (53) and Keratin 8 Kits (17) and many more products for this protein.
Showing 10 out of 744 products:
Human Monoclonal KRT8 Primary Antibody for FACS, IHC (fro) - ABIN112173
Ivanyi, Groeneveld, Van Doornewaard, Mooi, Hageman: Keratin subtypes in carcinomas of the uterine cervix: implications for histogenesis and differential diagnosis. in Cancer research 1990
Show all 13 references for ABIN112173
Human Monoclonal KRT8 Primary Antibody for IHC (fro), IF - ABIN1106942
Odin, Obrink: Quantitative determination of the organ distribution of the cell adhesion molecule cell-CAM 105 by radioimmunoassay. in Experimental cell research 1987
Show all 5 references for ABIN1106942
Hamster Monoclonal KRT8 Primary Antibody for IHC (fro), IF - ABIN112171
Bártek, Vojt?sek, Stasková, Bártková, Kerekés, Rejthar, Kovarík: A series of 14 new monoclonal antibodies to keratins: characterization and value in diagnostic histopathology. in The Journal of pathology 1991
Show all 5 references for ABIN112171
Human Polyclonal KRT8 Primary Antibody for IF, IHC (p) - ABIN197582
Nakamichi, Hatakeyama, Nakayama: Formation of Mallory body-like inclusions and cell death induced by deregulated expression of keratin 18. in Molecular biology of the cell 2002
Show all 4 references for ABIN197582
Human Monoclonal KRT8 Primary Antibody for FACS, IHC (fro) - ABIN112350
Guelstein, Tchypysheva, Ermilova, Litvinova, Troyanovsky, Bannikov: Monoclonal antibody mapping of keratins 8 and 17 and of vimentin in normal human mammary gland, benign tumors, dysplasias and breast cancer. in International journal of cancer. Journal international du cancer 1988
Show all 4 references for ABIN112350
Human Monoclonal KRT8 Primary Antibody for IHC (fro), IHC (p) - ABIN114674
Waseem, Karsten, Leigh, Purkis, Waseem, Lane: Conformational changes in the rod domain of human keratin 8 following heterotypic association with keratin 18 and its implication for filament stability. in Biochemistry 2004
Show all 2 references for ABIN114674
Chicken Polyclonal KRT8 Primary Antibody for IHC, WB - ABIN2777113
Moon, Yau, Wright, Zahradka: Injury-induced expression of cytokeratins 8 and 18 by vascular smooth muscle cells requires concurrent activation of cytoskeletal and growth factor receptors. in Canadian journal of physiology and pharmacology 2008
Human Monoclonal KRT8 Primary Antibody for ICC, IHC - ABIN969080
Walker, Harris, Holloway, McKenzie, Wells, Robinson, Morris: Cytokeratin KRT8/18 expression differentiates distinct subtypes of grade 3 invasive ductal carcinoma of the breast. in Cancer genetics and cytogenetics 2007
Cow (Bovine) Polyclonal KRT8 Primary Antibody for IHC, WB - ABIN2777112
Oh, Yang, Hahn, Kim, Byun, Jeon, Kim, Song, Noh, Kim, Yoo, Kim, Kim: Transcriptome analysis of human gastric cancer. in Mammalian genome : official journal of the International Mammalian Genome Society 2005
Data show that after siRNA transfection, TGF-beta1 (show TGFB1 Antibodies) protein level was decreased, and CK18 (show KRT18 Antibodies) proteins was decreased, while CK8 proteins was increased, and TERT (show TERT Antibodies) protein expression was slightly increased at 96 h.
The interplay between Solo protein and keratin 8/keratin 18 filaments plays a crucial role in tensile force-induced RhoA activation and consequent actin cytoskeletal reinforcement in endothelial cells.
K8/18 filaments provide resistance to apoptosis in granulosa cell tumor cells by impairing FAS (show FAS Antibodies) expression.
These metastatic tumors revealed no detectable expression of CK8/18, E-cadherin (show CDH1 Antibodies), VCAM-1 (show VCAM1 Antibodies), and ICAM-1 (show ICAM1 Antibodies)
Data show that loss of epithelial membrane protein 2 (EMP2) is involved in sphingosylphosphorylcholine (SPC (show UCN3 Antibodies))-induced phosphorylation of keratin 8 (K8) via ubiquitination of protein phosphatase 2 (PP2A (show PPP2R4 Antibodies)) through alpha4 phosphoprotein (show IGBP1 Antibodies) by caveolin-1 (cav-1 (show CAV1 Antibodies)).
In human failing myocardium, where TNF-alpha (show TNF Antibodies) expression is upregulated, K8/K18 (show KRT18 Antibodies) were also ectopically expressed
Human KRT8 variants promote acetaminophen induced hepatotoxicity in mouse models.
Syndecan-1 (show SDC1 Antibodies) is involved in morphogenesis of the developing tooth crown and cervical loops, andntogether with CK8 and vimentin (show VIM Antibodies) in differentiation of preameloblasts and preodontoblasts.
This is the first time intestinal cells have been suggested also functionally impaired by K8/K18 (show KRT18 Antibodies) mutations.
Study indicates that Piwil2 (show PIWIL2 Antibodies) plays a role in Fas (show FAS Antibodies)-mediated apoptosis and can affect p53 (show TP53 Antibodies) phosphorylation in tumor cells, revealing a novel mechanism of Piwil2 (show PIWIL2 Antibodies) in apoptosis, and supports that Piwil2 (show PIWIL2 Antibodies) plays an active role in tumorigenesis.
This study reveals clear genetic-statistical evidence for a link of KRT8, FAF1 (show FAF1 Antibodies) and PTH1R (show PTH1R Antibodies) with some of leg weakness related traits in pigs.
Mechanical injury of vascular smooth muscle up-regulated keratin 8.
Results did not support that K8/K18 (show KRT18 Antibodies) filaments influence the expression of Fas (show FAS Antibodies) on the surface of luteal cells.
Krt8 deletion (Krt8(-/-)) in a mouse model of cystic fibrosis (show S100A8 Antibodies) (F508del-Cftr (show CFTR Antibodies) mice) increased the levels of circulating markers of bone formation, corrected the expression of osteoblast phenotypic genes, promoted trabecular bone formation and improved bone mass and microarchitecture. Krt8 deletion corrected overactive NF-kappaB (show NFKB1 Antibodies) signaling & decreased Wnt (show WNT2 Antibodies)-beta-catenin (show CTNNB1 Antibodies) signaling induced by F508del-Cftr (show CFTR Antibodies) mutation in osteoblasts.
Autoantibodies to several antigens were identified in 81% of K8-null male mice 8 mo or older. Similar autoantibodies were detected in aging K18 (show KRT18 Antibodies)-null male mice that had a related liver phenotype but normal colon compared with K8-null mice
The regulation of the SCFA-MCT1 (show MCTS1 Antibodies)-HMGCS2 (show HMGCS2 Antibodies) axis is disrupted in K8(-/-) colonocytes, suggesting a role for keratins in colonocyte energy metabolism and homeostasis.
In several liver stress models epiplakin and K8 genes displayed identical expression patterns and transgenic K8 overexpression resulted in elevated hepatic epiplakin levels.
The findings demonstrate the near complete loss of K8/K18 (show KRT18 Antibodies) with concomitant high levels of vimentin (show VIM Antibodies) in CT26 (show DDX53 Antibodies) cells, a chemically-induced mouse colonic tumor.
Directed expression of a chimeric type II keratin (show KRT80 Antibodies) partially rescues keratin 5 (show KRT36 Antibodies)-null mice.
Keratin 8 is required for the maintenance of architectural structure in thymus epithelium.
A conserved rod domain phosphotyrosine that is targeted by the phosphatase PTP1B (show PTPN1 Antibodies) promotes keratin 8 protein insolubility and filament organization.
K8 acetylation at Lys (show LYZ Antibodies)-207, a highly conserved residue among type II keratins, is up-regulated upon hyperglycemia and down-regulated by SIRT2 (show SIRT2 Antibodies).
Data identify Danio rerio keratins 8/18 as the true orthologs of the human keratin pair 8/18.
This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene.
, keratin complex 2, basic, gene 5
, cytokeratin 8
, keratin, type II cytoskeletal 8
, type-II keratin Kb8
, cytokeratin endo A
, keratin complex 2, basic, gene 8
, keratin, type 2, gene 8