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Keratocan Proteins (KERA)

May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix.. Additionally we are shipping Keratocan Antibodies (41) and Keratocan Kits (13) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KERA 16545 O35367
Rat KERA KERA 314771  
KERA 11081 O60938
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Top Keratocan Proteins at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Yeast Cow His tag   1 mg Log in to see 56 to 66 Days
$2,896.67
Details
Yeast Chicken His tag   1 mg Log in to see 56 to 66 Days
$2,896.67
Details

KERA Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,
,

Top referenced Keratocan Proteins

  1. Human KERA Protein expressed in Wheat germ - ABIN1308536 : Zhang, Mao, Schwend, Littlechild, Conrad: Resistance of corneal RFUVA–cross-linked collagens and small leucine-rich proteoglycans to degradation by matrix metalloproteinases. in Investigative ophthalmology & visual science 2013 (PubMed)
    Show all 2 references for ABIN1308536

More Proteins for Keratocan (KERA) Interaction Partners

Zebrafish Keratocan (KERA) interaction partners

  1. Data indicate that mammalian keratocan is conserved in zebrafish in terms of gene structure, expression pattern, and promoter function.

Mouse (Murine) Keratocan (KERA) interaction partners

  1. rare variant in KERA was identified in a large kindred with premature atherosclerosis

  2. our results demonstrate the expression of keratocan by osteoblast lineage cells and its ability to modulate osteoblast function.

  3. Keratocan plays a unique role in maintaining the appropriate corneal shape to ensure normal vision

  4. Keratocan-deficient mice have corneal collagen fibrils with significantly larger diameters than those in wild-type mice, and increased centre-to-centre spacing of the fibrils.

  5. lumican (show LUM Proteins) has a novel regulatory role in keratocan expression at the transcriptional level

  6. lumican (show LUM Proteins) and keratocan core proteins bind the CXC chemokine (show CXCL12 Proteins) KC during a corneal inflammatory response, indicating that corneal KSPGs mediate neutrophil recruitment to the cornea by regulating chemokine (show CCL1 Proteins) gradient formation.

Human Keratocan (KERA) interaction partners

  1. The mutation that we report here leads to the deletion of a conserved amino acid (p.Phe125del) from the third LRR motif of the keratocan protein, which might lead to an abnormal tertiary structure of the protein, thereby leading to the disease.

  2. a novel KERA variant, p.(Ile225Thr), was detected that segregates with Cornea plana in the homozygous form.

  3. Corneal endothelial disorders were found with compound mutations in KERA

  4. rare variant in KERA was identified in a large kindred with premature atherosclerosis

  5. Linkage and haplotype analyses identified 12q21.33 as a locus for posterior amorphous corneal dystrophy. However, no mutations were identified in the candidate genes (KERA, LUM (show LUM Proteins), DCN (show DCN Proteins), EPYC (show EPYC Proteins)) within this region.

  6. KERA mutation is associated with autosomal recessive cornea plana

  7. This is the first report of the identification of a mutation within KERA in a family of Hispanic origin with autosomal recessive cornea plana.

  8. No evidence that endothelial dysfunction and germline mutation of lumican and keratocan genes participate in the etiology of subepithelial corneal haze.

  9. Specific for mutation in KERA, the ophthalmic phenotype of recessive cornea plana does not significantly vary with different KERA mutations.

  10. In addition, no pathogenic sequence variations were found in DCN (show DCN Proteins), DSPG3 (show EPYC Proteins), LUM (show LUM Proteins), PITX2 (show PITX2 Proteins) and FOXC1 (show FOXC1 Proteins), which have also been implicated in corneal and anterior segment dysgenesis.

Rabbit Keratocan (KERA) interaction partners

  1. FGF-2 (show FGF2 Proteins)- and TGF-beta1 (show TGFB1 Proteins)-activation of JNK (show MAPK8 Proteins) signaling pathway may be partly responsible for the downregulation of keratocan and lumican (show LUM Proteins) expression in activated corneal keratocytes observed during corneal stromal wound healing.

Keratocan (KERA) Protein Profile

Protein Summary

May be important in developing and maintaining corneal transparency and for the structure of the stromal matrix.

Gene names and symbols associated with Keratocan Proteins (KERA)

  • keratocan (KERA)
  • keratocan (kera)
  • keratocan (LOC100221424)
  • keratocan (Kera)
  • keratocan-like (LOC100157843)
  • CNA2 protein
  • KERA protein
  • si:dkeyp-38g8.3 protein
  • SLRR2B protein
  • zgc:136259 protein

Protein level used designations for Keratocan Proteins (KERA)

keratocan , keratocan-like , KTN , keratan sulfate proteoglycan keratocan , KSPG keratocan , corneal keratan sulfate proteoglycan 37A core protein

GENE ID SPECIES
467089 Pan troglodytes
567017 Danio rerio
709743 Macaca mulatta
100221424 Taeniopygia guttata
100406618 Callithrix jacchus
100433816 Pongo abelii
100593731 Nomascus leucogenys
16545 Mus musculus
314771 Rattus norvegicus
11081 Homo sapiens
280785 Bos taurus
373995 Gallus gallus
482598 Canis lupus familiaris
100009022 Oryctolagus cuniculus
100157843 Sus scrofa
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