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Ketohexokinase Proteins (KHK)

KHK encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. Additionally we are shipping Ketohexokinase Antibodies (109) and Ketohexokinase Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KHK 16548 P97328
Rat KHK KHK 25659 Q02974
KHK 3795 P50053
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Top Ketohexokinase Proteins at antibodies-online.com

Showing 10 out of 17 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 0.05 mg Log in to see 2 to 3 Days
$378.13
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated 100 μg Log in to see 7 to 8 Days
$286.00
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Pongo abelii His tag   1 mg Log in to see 56 to 66 Days
$2,786.67
Details
HOST_HEK-293 Cells Human His tag   50 μg Log in to see 5 Days
$352.00
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   1 mg Log in to see 3 to 4 Days
$2,524.50
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 μg Log in to see 6 to 11 Days
$142.86
Details
HOST_Human Human Un-conjugated   10 μg Log in to see 11 to 14 Days
$160.55
Details

KHK Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , , ,
,

Top referenced Ketohexokinase Proteins

  1. Human KHK Protein expressed in Escherichia coli (E. coli) - ABIN666920 : Diggle, Shires, Leitch, Brooke, Carr, Markham, Hayward, Asipu, Bonthron: Ketohexokinase: expression and localization of the principal fructose-metabolizing enzyme. in The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2009 (PubMed)
    Show all 2 references for ABIN666920

More Proteins for Ketohexokinase (KHK) Interaction Partners

Mouse (Murine) Ketohexokinase (KHK) interaction partners

  1. Feedforward upregulation of fructolytic and gluconeogenic enzymes specifically requires GLUT5 and KHK and may proactively enhance the intestine's ability to process anticipated increases in dietary fructose concentrations.

  2. Significant levels of blood fructose are maintained independent of dietary fructose, KHK, and GLUT5, probably by endogenous synthesis of fructose.

  3. myocardial hypoxia actuates fructose metabolism in human and mouse models of pathological cardiac hypertrophy through hypoxia-inducible factor 1alpha (HIF1alpha (show HIF1A Proteins)) activation of SF3B1 (show SF3B1 Proteins) and SF3B1 (show SF3B1 Proteins)-mediated splice switching of KHK-A to KHK-C

  4. Fructokinase-knockout mice with delayed hydration were protected from renal injury. Thus, recurrent dehydration can induce renal injury via a fructokinase-dependent mechanism, likely from the generation of endogenous fructose via the polyol pathway.

  5. This study demonstrates that blocking KHK and redirecting fructose metabolism to alternative pathways is an effective way to prevent visceral obesity and insulin (show INS Proteins) resistance induced by high fructose, a widespread component of Western diets.

  6. These studies identify fructokinase as a novel mediator of diabetic nephropathy and document a novel role for endogenous fructose production, or fructoneogenesis, in driving renal disease.

  7. High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase.

  8. Fructose-induced metabolic syndrome is prevented in mice lacking both fructokinase B and A but is exacerbated in mice lacking fructokinase A.

  9. These studies are the first demonstration that neither Khk isoform is required for normal growth and development.

Human Ketohexokinase (KHK) interaction partners

  1. myocardial hypoxia actuates fructose metabolism in human and mouse models of pathological cardiac hypertrophy through hypoxia-inducible factor 1alpha (HIF1alpha (show HIF1A Proteins)) activation of SF3B1 (show SF3B2 Proteins) and SF3B1 (show SF3B2 Proteins)-mediated splice switching of KHK-A to KHK-C

  2. These studies identify fructokinase as a novel mediator of diabetic nephropathy and document a novel role for endogenous fructose production, or fructoneogenesis, in driving renal disease.

  3. This study determined if single nucleotide polymorphisms in genes involved in fructose transport,SLC2A2 and SLC2A5 and metabolism, etohexokinase affect inter-individual variability in metabolic phenotypes.

  4. In human hepatocytes uric acid up-regulates KHK expression thus leading to the amplification of the lipogenic effects of fructose.

  5. ketohexokinase-A serves an unknown physiologic function that remains intact in essential fructosuria.

  6. The expression of ketohexokinase is diminished in human clear cell type of renal cell carcinoma (show MOK Proteins)

  7. Ketohexokinase-dependent metabolism of fructose induces proinflammatory mediators in proximal tubular cells.

  8. The structure of the KHK-A ternary complex revealed an active site with fructose & the ATP analogue in positions ready for phosphorylation. The effects of the pathogenic mutations Gly40Arg & Ala43Thr have been modelled in the context of the KHK structure.

Ketohexokinase (KHK) Protein Profile

Protein Summary

This gene encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. The product of this gene is the first enzyme with a specialized pathway that catabolizes dietary fructose. Alternatively spliced transcript variants encoding different isoforms have been identified.

Gene names and symbols associated with Ketohexokinase Proteins (KHK)

  • ketohexokinase-like (LOC100055449)
  • ketohexokinase (khk)
  • ketohexokinase (KHK)
  • ketohexokinase (Hhal_0921)
  • ketohexokinase (AaeL_AAEL006316)
  • Ketohexokinase (Nwat_0240)
  • Ketohexokinase (khk)
  • ketohexokinase (LOC100351729)
  • ketohexokinase (Khk)
  • ketohexokinase (fructokinase) (KHK)
  • ketohexokinase-like (LOC100523241)
  • KETHPRO protein
  • khk protein
  • wu:fj68h03 protein
  • zgc:92219 protein
  • zgc:92626 protein

Protein level used designations for Ketohexokinase Proteins (KHK)

ketohexokinase , Ketohexokinase , hepatic fructokinase

GENE ID SPECIES
100055449 Equus caballus
436909 Danio rerio
698328 Macaca mulatta
4710193 Halorhodospira halophila SL1
5567860 Aedes aegypti
9391692 Nitrosococcus watsonii C-113
100306748 Salmo salar
100351729 Oryctolagus cuniculus
16548 Mus musculus
25659 Rattus norvegicus
3795 Homo sapiens
100170647 Canis lupus familiaris
614868 Bos taurus
100447147 Pongo abelii
100523241 Sus scrofa
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