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Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. Additionally we are shipping Killer Cell Immunoglobulin Like Receptor 2DS1 Antibodies (30) and many more products for this protein.
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functional interactions between KIR (show GEM Proteins) and HLA modify risks of BCC and SCC (show CYP11A1 Proteins) and that KIR (show GEM Proteins) encoded by the B genes provides selective pressure for altered p53 (show TP53 Proteins) in BCC tumors.
The activating KIR (show GEM Proteins) gene KIR2DS1 has an important predictive potential for early onset of type 1 autoimmune hepatitis.
Absence of HLA-C2 for donor KIR2DL1 (show KIR2DL1 Proteins) was associated with higher grade II to IV (HR, 1.4; P = .002) and III to IV acute GVHD (HR, 1.5; P = .01) compared with HLA-C2(+) patients.
frequency of the maternal KIR2DS1 gene lower in the preeclampsia group than control group
Array CGH showed a 95 Kb de novo duplication on chromosome 19q13.4 encompassing four killer cell immunoglobulin-like receptor (KIR) genes.
Data show that KIR2DL5 receptor, KIR2DS1 protein, KIR2DS5 protein and KIR3DS1 receptors were all significantly associated with high viral load.
the frequencies of HLA-Cw07 were statistically significantly higher in the patient group than those in the control group (P = 0.009). KIR2DS1(+) HLA(-) Cw(Lys (show LYZ Proteins)) was more common in subjects with SLE
Moreover, the frequency of activating genotypes in the AS patient group was significantly higher than in the healthy control group (P < 0.05). KIR2DS1 and KIR3DS1
Effect of KIR2DS1 was most significant in pregnancies where its ligand, HLA-C2, was paternally but not maternally inherited by a fetus (p = 0.005, odds ratio = 2.65).
Different expression levels of KIR2DL1 (show KIR2DL1 Proteins) may contribute to the abnormal function of natural killer (NK) and NKT (show SLC22A6 Proteins) lymphocytes, which lead to the risk of systemic lupus erythematosus (SLE) susceptibility.
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules\\\\; thus, KIR proteins are thought to play an important role in regulation of the immune response.
CD158 antigen-like family member H
, MHC class I NK cell receptor Eb6 ActI
, killer cell immunoglobulin-like receptor 2DS1
, killer cell immunoglobulin-like receptor KIRDS1
, killer-cell immunoglobulin-like receptor
, CD158 antigen-like family member Z
, killer cell Ig-like receptor KIR3DL7
, killer cell immunoglobulin-like receptor 3DL3
, killer cell inhibitory receptor 1