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Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 4 Proteins (KIR2DL4)

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. Additionally we are shipping Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 4 Antibodies (116) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KIR2DL4 3805 Q99706
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Top Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 4 Proteins at antibodies-online.com

Showing 7 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_CHO Cells Human Fc Tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
HOST_HEK293 Human His tag   50 μg Log in to see 5 Days
$280.50
Details
HOST_Wheat germ Human Un-conjugated   10 μg Log in to see 9 Days
$641.43
Details
HOST_Human Human Un-conjugated   10 μg Log in to see 11 to 14 Days
$160.55
Details

KIR2DL4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
, , ,

Top referenced Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 4 Proteins

  1. Human KIR2DL4 Protein expressed in CHO Cells - ABIN2005389 : Selvakumar, Steffens, Dupont: NK cell receptor gene of the KIR family with two IG domains but highest homology to KIR receptors with three IG domains. in Tissue antigens 1997 (PubMed)
    Show all 2 references for ABIN2005389

More Proteins for Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 4 (KIR2DL4) Interaction Partners

Human Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 4 (KIR2DL4) interaction partners

  1. Decreased level of KIR2DL4 rather than its single nucleotide polymorphism is correlated with the susceptibility of pre-eclampsia

  2. the KIR2DL4 on human mast cells facilitates HLA-G (show HLAG Proteins)-expressing cancer invasion and the subsequent metastasis.

  3. Among 438 Polish people, a weak difference was seen between males and females in 9769 C/A genotypes and alleles. Fertile women had a high frequency of homozygosity for the defective 9A variant, so KIR2DL4 is not absolutely necessary for reproduction.

  4. Array CGH showed a 95 Kb de novo duplication on chromosome 19q13.4 encompassing four killer cell immunoglobulin-like receptor (KIR) genes.

  5. Results show that HLA-E (show HLAE Proteins) and KIR2DL4 demonstrate evidence of positive selection between human, chimpanzee and gorilla suggesting a main role for immunological adaptations linked to embryo deep invasion of the maternal endometrium during pregnancy.

  6. The unique functional properties of KIR2DL4 may be mediated by self-association of the receptor.

  7. Genetic polymorphism of KIR2DL4, a putative NK cell receptor for HLA-G (show HLAG Proteins), does not influence susceptibility to asthma.

  8. Abs to KIR2DL4 and HLA-G (show HLAG Proteins) did not block NK cell IFN-gamma (show IFNG Proteins) production.

  9. KIR2DL4 was found to directly interact with HS/heparin, and the D0 domain of KIR2DL4 was essential for this interaction.

  10. Beta Microglobulin-free HLA-G (show HLAG Proteins) activates NK cells via engagement of KIR2DL4 receptors.

Rhesus Monkey Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 4 (KIR2DL4) interaction partners

  1. Higher KIR2DL4 copy numbers is associated with an increased IFN-gamma production in NK cell subsets in SIV-infected Mamu-A*01-negative rhesus macaques.

  2. In the Indian population, two different KIR2DL4 entities are encountered, which differ in their intra-cellular signalling motifs. One genotype contains a complex mutation in the distal region of exon 9, which negates a serine/threonine kinase site.

Killer Cell Immunoglobulin-Like Receptor, Two Domains, Long Cytoplasmic Tail, 4 (KIR2DL4) Protein Profile

Protein Summary

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules\\\\; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the 'framework' loci that is present on all haplotypes. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with KIR2DL4

  • killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 (KIR2DL4)
  • killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A (KIR2DL5A)
  • CD158D protein
  • G9P protein
  • KIR2DL1 protein
  • KIR2DL4 protein
  • KIR103 protein
  • KIR103AS protein

Protein level used designations for KIR2DL4

CD158 antigen-like family member D , KIR-103AS , MHC class I NK cell receptor KIR103AS , NK cell receptor , killer Ig receptor , killer cell immunoglobulin-like receptor 2DL4 , killer cell inhibitory receptor 103AS , natural killer cell inhibitory receptor , killer cell immunoglobulin-like receptor 2DL5A , killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 1 , killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4 , killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5 , killer cell immunoglobulin-like receptor KIR2DL4 , killer cell immunogobulin-like receptor two domains long cytoplasmic tail 4

GENE ID SPECIES
3805 Homo sapiens
282860 Bos taurus
450205 Pan troglodytes
722782 Macaca mulatta
100137355 Papio anubis
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