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Killer Cell Immunoglobulin-Like Receptor, Two Domains, Short Cytoplasmic Tail, 4 Proteins (KIR2DS4)

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. Additionally we are shipping Killer Cell Immunoglobulin-Like Receptor, Two Domains, Short Cytoplasmic Tail, 4 Antibodies (44) and Killer Cell Immunoglobulin-Like Receptor, Two Domains, Short Cytoplasmic Tail, 4 Kits (3) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KIR2DS4 3809 P43632
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Top Killer Cell Immunoglobulin-Like Receptor, Two Domains, Short Cytoplasmic Tail, 4 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated Figure annotation denotes ug of protein loaded and % gel used. 100 μg Log in to see 7 to 9 Days
$467.86
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 11 to 13 Days
$612.70
Details
HOST_Escherichia coli (E. coli) Human Un-conjugated   5 μg Log in to see 6 to 11 Days
$142.86
Details

KIR2DS4 Proteins by Origin and Source

Origin Expressed in Conjugate
Human ,
,

More Proteins for Killer Cell Immunoglobulin-Like Receptor, Two Domains, Short Cytoplasmic Tail, 4 (KIR2DS4) Interaction Partners

Human Killer Cell Immunoglobulin-Like Receptor, Two Domains, Short Cytoplasmic Tail, 4 (KIR2DS4) interaction partners

  1. genetic association study in population in Eastern India: Data suggest that interactions between KIRs (KIR2DL2 (show KIR2DL2 Proteins), KIR2DS4, KIR2DL3 (show KIR2DL3 Proteins)) and HLA ligands (HLAC1, HLAC2) contribute significantly toward susceptibility and protection toward type 1 diabetes.

  2. KIR2DS4 can induce the uptake of CCR7 (show CCR7 Proteins) by KIR2DS4(+) NKG2A (show KLRC1 Proteins)(+) natural killer cell clones after interacting with CCR7 (show CCR7 Proteins)(+) target cells expressing HLA-Cw4 and HLA-Cw6 alleles.

  3. Study shows KIR3DL1 and KIR2DS4 gene variants are linked and that the gene KIR2DS5 is only present in the telomeric half of the KIR locus. Study revealed novel insights in the highly organized distribution of KIR genes.

  4. KIR2DS4del presence in patients was associated with severity of endometriosis, which, due to strong negative linkage disequilibrium, may suggest an indirect effect of KIR2DS5 absence

  5. Response of rheumatoid arthritis patients with medium ESR (show ESR1 Proteins) values to methotrexate treatment may be dependent on the full-length KIR2DS4 gene.

  6. Possession of the functional and non-functional KIR2DS4 isoforms in the mother and the fetus determines the risk of the vertical HIV-1 transmission.

  7. Data indicate that positive linkage disequilibrium was observed between KIR3DL1, 2DL1, 2DL3 and 2DS4 which is consistent with the associations between the constituents of A haplotypes.

  8. Our data revealed a unique contribution of activating KIRs (KIR2DS4, KIR2DS2 (show KIR2DS2 Proteins), or KIR3DS1), in addition to NKG2C (show KLRC2 Proteins), in the expansion of human natural killer cells.

  9. in response to HCT therapy, the activating receptors are also enhanced by a process that increases the number of unmethylated sites present on KIR2DS2 (show KIR2DS2 Proteins)/4 promoters.

  10. Results suggest a protective role of KIR2DS5 in graft rejection and an association of KIR2DS4 with kidney rejection, particularly in recipients with glomerulonephritis.

Killer Cell Immunoglobulin-Like Receptor, Two Domains, Short Cytoplasmic Tail, 4 (KIR2DS4) Protein Profile

Protein Summary

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules\; thus, KIR proteins are thought to play an important role in regulation of the immune response.

Gene names and symbols associated with KIR2DS4

  • killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4 (KIR2DS4)
  • CD158I protein
  • KIR1D protein
  • KIR412 protein
  • KKA3 protein
  • NKAT8 protein

Protein level used designations for KIR2DS4

CD158 antigen-like family member I , KIR antigen 2DS4 , MHC class I NK cell receptor , NKAT-8 , P58 natural killer cell receptor clones CL-39/CL-17 , killer cell immunoglobulin-like receptor 2DS4 , killer inhibitory receptor 4-1-2 , natural killer cell inhibitory receptor , natural killer-associated transcript 8 , p58 NK receptor CL-39/CL-17

GENE ID SPECIES
3809 Homo sapiens
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