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Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. Additionally we are shipping KIR2DL5A Antibodies (22) and many more products for this protein.
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KIR2DL5 (show KIR2DL5B Proteins) gene polymorphism is associated with HIV-1 infection.
We observed statistically lower carrier frequencies of cB03|tA01 gene-content haplotype, of cB03 haplotype motif, of the KIR2DL5 (show KIR2DL5B Proteins) + 2DS3/2DS5 gene pair and of KIR2DL5 (show KIR2DL5B Proteins) amongst CMV-positive pregnant women in comparison with those CMV negative
Data show that KIR2DL5 receptor, KIR2DS1 protein, KIR2DS5 protein and KIR3DS1 receptors were all significantly associated with high viral load.
The genes KIR2DL5, KIR2DS3 and KIR2DS5 were present in a significantly higher proportion of individuals in the asymptomatic control group than in the malaria cases.
indicate that killer-cell immunoglobulin-like receptors (KIRs)activator (KIR3DS1 and KIR2DS5) and inhibitory (KIR2DL5 (show KIR2DL5B Proteins)) genes are associated with severe pandemic influenza A (H1N1) 2009 infections.
KIR2DL5 (show KIR2DL5B Proteins) is a candidate gene involved in immunomodulation associated with non-response to antiviral therapy.
Human KIR2DL5 has at least 4 gene variants, whose exons differ by 2 to 8 nucleotides. These structurally similar variants are encoded by alleles of 2 different loci, KIR2DL5A and KIR2DL5B, which map to different regions of the KIR-gene cluster.
The frequencies of KIR2DS1 (show KIR2DS1 Proteins) and KIR2DL5 (show KIR2DL5B Proteins) were significantly increased in psoriasis vulgaris cases compared with controls
We report here the identification and characterization of the receptor encoded by KIR2DL5 (show KIR2DL5B Proteins) using a newly generated specific mAb that recognizes its most commonly expressed allele, KIR2DL5A*001.
Sequencing a KIR2DL5 (show KIR2DL5B Proteins) variant using a first-generation high-throughput method proves it is a newly discovered allele, one that appears associated with Hispanic and Native American populations.
Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules\; thus, KIR proteins are thought to play an important role in regulation of the immune response.
killer cell immunoglobulin-like receptor 2DL5A
, killer cell immunoglobulin-like receptor KIR2DL5A
, killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5
, killer-cell Ig-like receptor