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Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. Additionally we are shipping Killer Cell Lectin-Like Receptor Subfamily C, Member 1 Proteins (9) and many more products for this protein.
Showing 10 out of 99 products:
Mouse (Murine) Monoclonal KLRC1 Primary Antibody for FACS - ABIN2662464
Silver, Lau, Kane: Molecular cloning of mouse NKG2A and C. in Immunogenetics 1999
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Mouse (Murine) Monoclonal KLRC1 Primary Antibody for ICFC - ABIN2656956
Sivakumar, Gunturi, Salcedo, Schatzle, Lai, Kurepa, Pitcher, Seaman, Lemonnier, Bennett, Forman, Kumar: Cutting edge: expression of functional CD94/NKG2A inhibitory receptors on fetal NK1.1+Ly-49- cells: a possible mechanism of tolerance during NK cell development. in Journal of immunology (Baltimore, Md. : 1950) 1999
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Mouse (Murine) Monoclonal KLRC1 Primary Antibody for FACS, IHC - ABIN2660820
Vance, Jamieson, Raulet: Recognition of the class Ib molecule Qa-1(b) by putative activating receptors CD94/NKG2C and CD94/NKG2E on mouse natural killer cells. in The Journal of experimental medicine 2000
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Human Polyclonal KLRC1 Primary Antibody for EIA, IF - ABIN953105
Ma, Guo, Wu, Li, Zhu, Li, Li, Pan, Li, Li, Liu: Association of NKG2D genetic polymorphism with susceptibility to chronic hepatitis B in a Han Chinese population. in Journal of medical virology 2010
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Human Polyclonal KLRC1 Primary Antibody for ELISA, WB - ABIN1452141
Sullivan, Clements, Beddoe, Johnson, Hoare, Lin, Huyton, Hopkins, Reid, Wilce, Kabat, Borrego, Coligan, Rossjohn, Brooks: The heterodimeric assembly of the CD94-NKG2 receptor family and implications for human leukocyte antigen-E recognition. in Immunity 2007
Show all 2 references for ABIN1452141
Human Polyclonal KLRC1 Primary Antibody for EIA, WB - ABIN453718
Plougastel, Jones, Trowsdale: Genomic structure, chromosome location, and alternative splicing of the human NKG2A gene. in Immunogenetics 1996
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CD94 (show KLRD1 Antibodies) and NKG2A polymorphisms may contribute to genetic susceptibility to rheumatoid arthritis or affect the response to anti-TNF (show TNF Antibodies) therapy in patients of Caucasian origin.
NK cell maturation to CD56(dim) subset associated with high levels of NCRs overrides the inhibitory effect of NKG2A and recovers impaired NK cell cytolytic potential after allogeneic hematopoietic stem cell transplantation.
Coengagement of inhibitory receptors, either KIR2DL1 (show KIR2DL1 Antibodies) or CD94 (show KLRD1 Antibodies)-NKG2A, did not inhibit phosphorylation of Stat5 (show STAT5A Antibodies) but inhibited selectively phosphorylation of Akt (show AKT1 Antibodies) and S6 ribosomal protein (show RPS6 Antibodies).
The presence of TIM3 (show HAVCR2 Antibodies)+and/or NKG2A+ T cells is associated with the absence of recurrences and a longer recurrence-free survival.
Balance between activating NKG2D (show KLRK1 Antibodies), DNAM-1 (show CD226 Antibodies), NKp44 (show NCR2 Antibodies) and NKp46 (show NCR1 Antibodies) and inhibitory CD94 (show KLRD1 Antibodies)/NKG2A receptors determine natural killer degranulation towards rheumatoid arthritis synovial fibroblasts.
Results suggested that the low expression level of CD94 (show KLRD1 Antibodies)/NKG2A upon gammadelta T cell activation might lead to the over-activation of gammadelta T cells in patients with SLE.
The positive expression rate of NKG2D (show KLRK1 Antibodies) and NKG2A on NK cells and CD3 (show CD3 Antibodies)(+) T cells in ALL patients was no significantly different from that in AML (show RUNX1 Antibodies) patients.
The level of NKG2A expression on resting CD8 (show CD8A Antibodies)-positive T cells inversely correlated with acquisition of regulatory function when activated.
These results suggested that these glycans can interact with NKG2D (show KLRK1 Antibodies) and CD94 (show KLRD1 Antibodies) to modulate NK cell-dependent cytotoxicity.
The differences of CD94 (show KLRD1 Antibodies) and NKG2 expression between nasal NK/T-cell lymphomas and B cell lymphoma or T cell lymphoma were statistically significant.
NKG2A optimizes CD8 (show CD8A Antibodies)(+) T cell responses during an acute poxvirus infection.
Results demonstrate the immunoregulatory role of CD8 (show CD8A Antibodies)(+) NKG2A expression in virus infection, which negatively regulates T cell effector functions and contributes to protection of tissue integrity during virus clearance.
role in NK cell-mediated protection from DSS (show PMP22 Antibodies)-induced colitis
Endogenous NKG2A contributes to the rejection of cells lacking human HLA-Cw3.
The complex interplay between various stimuli may account for the variable expression of CD94 (show KLRD1 Antibodies)/NKG2A during responses to different pathogens in vivo.
expression of CD94 (show KLRD1 Antibodies) and its associated NKG2A, NKG2C (show KLRC2 Antibodies), and NKG2E (show KLRC3 Antibodies) subunits is dispensable for NK cell development, education, and many NK cell functions
The NKG2A+KLRG1 (show KLRG1 Antibodies)+ positive phenotype correlates with protective efficacy during antigenic recall from a pool of CD8 (show CD8A Antibodies) T cells during persistent gamma-herpesvirus 68 infection.
Data suggest that the liver environment regulates NK cell receptor expression and that IL-10 contributes to the regulation of liver NK cells, in part, by maintaining a greater percentage of the hyporesponsive NKG2A(+)Ly49(-) NK cells in the liver.
Implications of CD94 (show KLRD1 Antibodies) deficiency and monoallelic NKG2A expression for natural killer cell development and repertoire formation.
the CD94 (show KLRD1 Antibodies)/NKG2A inhibitory receptor plays a critical role in down-regulating invariant NK-cell responses
Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed.
natural killer cell protein group 2-A (NKG2A)
, CD159 antigen-like family member A
, NK cell receptor A
, NKG2-A/B-activating NK receptor
, NKG2-A/NKG2-B type II integral membrane protein
, killer cell lectin-like receptor subfamily C, member 1
, C-lectin type II protein
, NKG2-1/B activating NK receptor
, NKG2-A/B type II integral membrane protein
, natural killer cell lectin
, natural killer group protein 2