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Killer Cell Lectin-Like Receptor Subfamily C, Member 1 Proteins (KLRC1)

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. Additionally we are shipping Killer Cell Lectin-Like Receptor Subfamily C, Member 1 Antibodies (98) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
Rat KLRC1 KLRC1 29683  
KLRC1 3821 P26715
KLRC1 16641  
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Top Killer Cell Lectin-Like Receptor Subfamily C, Member 1 Proteins at antibodies-online.com

Showing 8 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Human Cells Mouse His tag 50 μg Log in to see 16 Days
$382.80
Details
HOST_Human Cells Cynomolgus Fc Tag 100 μg Log in to see 16 Days
$437.80
Details
HOST_Human Cells Human His tag 50 μg Log in to see 16 Days
$382.80
Details
HOST_Wheat germ Human GST tag 10 μg Log in to see 9 Days
$405.71
Details
Yeast Macaca mulatta His tag   1 mg Log in to see 56 to 66 Days
$2,299.00
Details
HOST_Wheat germ Human Un-conjugated   10 μg Log in to see 9 Days
$641.43
Details

KLRC1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
, ,
Mouse (Murine)

More Proteins for Killer Cell Lectin-Like Receptor Subfamily C, Member 1 (KLRC1) Interaction Partners

Human Killer Cell Lectin-Like Receptor Subfamily C, Member 1 (KLRC1) interaction partners

  1. CD94 (show KLRD1 Proteins) and NKG2A polymorphisms may contribute to genetic susceptibility to rheumatoid arthritis or affect the response to anti-TNF (show TNF Proteins) therapy in patients of Caucasian origin.

  2. NK cell maturation to CD56(dim) subset associated with high levels of NCRs overrides the inhibitory effect of NKG2A and recovers impaired NK cell cytolytic potential after allogeneic hematopoietic stem cell transplantation.

  3. Coengagement of inhibitory receptors, either KIR2DL1 (show KIR2DL1 Proteins) or CD94 (show KLRD1 Proteins)-NKG2A, did not inhibit phosphorylation of Stat5 (show STAT5A Proteins) but inhibited selectively phosphorylation of Akt (show AKT1 Proteins) and S6 ribosomal protein (show RPS6 Proteins).

  4. The presence of TIM3 (show HAVCR2 Proteins)+and/or NKG2A+ T cells is associated with the absence of recurrences and a longer recurrence-free survival.

  5. Balance between activating NKG2D (show KLRK1 Proteins), DNAM-1 (show CD226 Proteins), NKp44 (show NCR2 Proteins) and NKp46 (show NCR1 Proteins) and inhibitory CD94 (show KLRD1 Proteins)/NKG2A receptors determine natural killer degranulation towards rheumatoid arthritis synovial fibroblasts.

  6. Results suggested that the low expression level of CD94 (show KLRD1 Proteins)/NKG2A upon gammadelta T cell activation might lead to the over-activation of gammadelta T cells in patients with SLE.

  7. The positive expression rate of NKG2D (show KLRK1 Proteins) and NKG2A on NK cells and CD3 (show CD3 Proteins)(+) T cells in ALL patients was no significantly different from that in AML (show RUNX1 Proteins) patients.

  8. The level of NKG2A expression on resting CD8 (show CD8A Proteins)-positive T cells inversely correlated with acquisition of regulatory function when activated.

  9. These results suggested that these glycans can interact with NKG2D (show KLRK1 Proteins) and CD94 (show KLRD1 Proteins) to modulate NK cell-dependent cytotoxicity.

  10. The differences of CD94 (show KLRD1 Proteins) and NKG2 expression between nasal NK/T-cell lymphomas and B cell lymphoma or T cell lymphoma were statistically significant.

Mouse (Murine) Killer Cell Lectin-Like Receptor Subfamily C, Member 1 (KLRC1) interaction partners

  1. NKG2A optimizes CD8 (show CD8A Proteins)(+) T cell responses during an acute poxvirus infection.

  2. Results demonstrate the immunoregulatory role of CD8 (show CD8A Proteins)(+) NKG2A expression in virus infection, which negatively regulates T cell effector functions and contributes to protection of tissue integrity during virus clearance.

  3. role in NK cell-mediated protection from DSS (show PMP22 Proteins)-induced colitis

  4. Endogenous NKG2A contributes to the rejection of cells lacking human HLA-Cw3.

  5. The complex interplay between various stimuli may account for the variable expression of CD94 (show KLRD1 Proteins)/NKG2A during responses to different pathogens in vivo.

  6. expression of CD94 (show KLRD1 Proteins) and its associated NKG2A, NKG2C (show KLRC2 Proteins), and NKG2E (show KLRC3 Proteins) subunits is dispensable for NK cell development, education, and many NK cell functions

  7. The NKG2A+KLRG1 (show KLRG1 Proteins)+ positive phenotype correlates with protective efficacy during antigenic recall from a pool of CD8 (show CD8A Proteins) T cells during persistent gamma-herpesvirus 68 infection.

  8. Data suggest that the liver environment regulates NK cell receptor expression and that IL-10 contributes to the regulation of liver NK cells, in part, by maintaining a greater percentage of the hyporesponsive NKG2A(+)Ly49(-) NK cells in the liver.

  9. Implications of CD94 (show KLRD1 Proteins) deficiency and monoallelic NKG2A expression for natural killer cell development and repertoire formation.

  10. the CD94 (show KLRD1 Proteins)/NKG2A inhibitory receptor plays a critical role in down-regulating invariant NK-cell responses

Killer Cell Lectin-Like Receptor Subfamily C, Member 1 (KLRC1) Protein Profile

Protein Summary

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. The protein encoded by this gene belongs to the killer cell lectin-like receptor family, also called NKG2 family, which is a group of transmembrane proteins preferentially expressed in NK cells. This family of proteins is characterized by the type II membrane orientation and the presence of a C-type lectin domain. This protein forms a complex with another family member, KLRD1/CD94, and has been implicated in the recognition of the MHC class I HLA-E molecules in NK cells. The genes of NKG2 family members form a killer cell lectin-like receptor gene cluster on chromosome 12. Four alternatively spliced transcript variants encoding two distinct isoforms have been observed.

Gene names and symbols associated with KLRC1

  • killer cell lectin-like receptor subfamily C, member 1 (Klrc1)
  • killer cell lectin-like receptor subfamily C, member 1 (KLRC1)
  • killer cell lectin-like receptor subfamily C, member 3 (KLRC3)
  • CD159a protein
  • KLRC1 protein
  • NKG2 protein
  • NKG2-A protein
  • NKG2A protein
  • NKG2B protein
  • rNKG2A protein

Protein level used designations for KLRC1

natural killer cell protein group 2-A (NKG2A) , CD159 antigen-like family member A , NK cell receptor A , NKG2-A/B-activating NK receptor , NKG2-A/NKG2-B type II integral membrane protein , killer cell lectin-like receptor subfamily C, member 1 , C-lectin type II protein , NKG2-1/B activating NK receptor , NKG2-A/B type II integral membrane protein , natural killer cell lectin , natural killer group protein 2

GENE ID SPECIES
29683 Rattus norvegicus
450131 Pan troglodytes
514897 Bos taurus
611325 Canis lupus familiaris
100126720 Papio anubis
100144622 Sus scrofa
3821 Homo sapiens
16641 Mus musculus
574146 Macaca mulatta
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