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KLRF1, an activating homodimeric C-type lectin-like receptor (CTLR), is expressed on nearly all natural killer (NK) cells and stimulates their cytoxicity and cytokine release (Kuttruff et al., 2009 [PubMed 18922855]).[supplied by OMIM, Oct 2009].. Additionally we are shipping Killer Cell Lectin-Like Receptor Subfamily F, Member 1 Antibodies (11) and many more products for this protein.
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Cynomolgus KLRF1 Protein expressed in Human Cells - ABIN2009940
Kuttruff, Koch, Kelp, Pawelec, Rammensee, Steinle: NKp80 defines and stimulates a reactive subset of CD8 T cells. in Blood 2009
IL-15 (show IL15 Proteins)+IL-12 (show IL12A Proteins) has an immunomodulatory effect on NK cell subsets from HIV-infected individuals viz down-regulation of iNKRs, elevation of activatory receptors NKp46 (show NCR1 Proteins) and NKG2D (show KLRK1 Proteins), and induction of coreceptor NKp80.
our data report a previously unrecognized regulatory circuit enabling autonomous control of human NK cell responses via the NKp80-AICL (show CLEC2B Proteins) axis.
Two non-consensus amino acids of NKp80, in particular arginine 6, critically impair both hemi-immunoreceptor tyrosine-based activation motif phosphorylation and Syk (show SYK Proteins) recruitment.
Activating receptor NKp80 induces cytotoxicity by using an atypical hemi-ITAM amino acid seqeuence and the Syk (show SYK Proteins)-kinase pathway.
NKp80 is expressed on a highly responsive subset of effector memory CD8 (show CD8A Proteins) T cells with an inflammatory NK-like phenotype and promotes T-cell responses toward AICL (show CLEC2B Proteins)-expressing cells.
phenotypic, molecular, and functional characterization for triggering molecules (NKp46 (show NCR1 Proteins), NKp30 (show NCR3 Proteins) NKp80, and NKG2D (show KLRK1 Proteins); in this AIDS-resistant species, relevant differences to human NK cells involve NKp80 and particularly NKp30 (show NCR3 Proteins)
KLRF1, an activating homodimeric C-type lectin-like receptor (CTLR), is expressed on nearly all natural killer (NK) cells and stimulates their cytoxicity and cytokine release (Kuttruff et al., 2009
C-type lectin domain family 5 member C
, activating coreceptor NKp80
, killer cell lectin-like receptor F1
, killer cell lectin-like receptor subfamily F member 1
, lectin-like receptor F1
, killer cell lectin-like receptor subfamily F, member 1
, NKp80 receptor