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Killer Cell Lectin-Like Receptor Subfamily K, Member 1 Proteins (KLRK1)

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. Additionally we are shipping Killer Cell Lectin-Like Receptor Subfamily K, Member 1 Antibodies (167) and Killer Cell Lectin-Like Receptor Subfamily K, Member 1 Kits (4) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KLRK1 22914 P26718
KLRK1 27007 O54709
KLRK1 24934 O70215
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Top Killer Cell Lectin-Like Receptor Subfamily K, Member 1 Proteins at antibodies-online.com

Showing 10 out of 17 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_CHO Cells Human Fc Tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Baculovirus infected Insect Cells Human His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Baculovirus infected Insect Cells Cynomolgus His tag 100 μg Log in to see 16 Days
$382.80
Details
HOST_Escherichia coli (E. coli) Human His tag 100 μg Log in to see 7 to 8 Days
$319.00
Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 49 to 54 Days
$4,244.78
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HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg Log in to see 49 to 54 Days
$6,041.49
Details
HOST_Wheat germ Human GST tag 2 μg Log in to see 9 Days
$333.33
Details
Yeast Wild boar His tag   1 mg Log in to see 56 to 66 Days
$2,289.83
Details

KLRK1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , ,
, , ,
Mouse (Murine) ,
,
Rat (Rattus)

Top referenced Killer Cell Lectin-Like Receptor Subfamily K, Member 1 Proteins

  1. Human KLRK1 Protein expressed in Escherichia coli (E. coli) - ABIN1098706 : Guerra, Tan, Joncker, Choy, Gallardo, Xiong, Knoblaugh, Cado, Greenberg, Greenberg, Raulet: NKG2D-deficient mice are defective in tumor surveillance in models of spontaneous malignancy. in Immunity 2008 (PubMed)
    Show all 2 references for ABIN1098706

  2. Human KLRK1 Protein expressed in CHO Cells - ABIN2003085 : Houchins, Yabe, McSherry, Bach: DNA sequence analysis of NKG2, a family of related cDNA clones encoding type II integral membrane proteins on human natural killer cells. in The Journal of experimental medicine 1991 (PubMed)

More Proteins for Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1) Interaction Partners

Human Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1) interaction partners

  1. data suggest that STAT3 contributes to NK cell recognition by modulating NKG2D ligands in K562/AO2 cells, which may a mechanism by which cells survive and cause relapse of leukemia.

  2. These results suggest that NKG2D-DAP10 (show HCST Proteins) endocytosis represents a means to decrease cell surface receptor abundance, as well as to control signaling outcome in cytotoxic lymphocytes.

  3. The reduced cell surface expression of NKG2D in response to engagement by MICA (show MICA Proteins)-129Met variants appeared to reduce the severity of acute graft-versus-host disease.

  4. Bispecific protein rG7S-MICA (show MICA Proteins) recruits natural killer cells and enhances NKG2D-mediated immunosurveillance against hepatocellular carcinoma.

  5. Taken together, these results demonstrate that endogenous levels of IFN-alpha (show IFNA Proteins) secreted by plasmacytoid dendritic cells induce natural killer cells to lyse HIV-1-infected autologous CD4 (show CD4 Proteins)+ primary T cells via the engagement of NKp46 (show NCR1 Proteins) and NKG2D.

  6. these findings suggest that TGFbetainduced release of soluble MICA (show MICA Proteins) leads to downregulation of NKG2D, thereby preventing NK cellmediated cytotoxicity toward renal proximal tubular epithelial cells in renal IRI

  7. In conclusion DNT (show NT5C Proteins) cell can significantly inhibit the growth of pancreatic carcinoma in vivo, and the mechanism may be involved in abnormal expressions of MICA (show MICA Proteins) and NKG2D.

  8. study indicates a direct NKG2D-dependent stimulatory effect of human CD34+ cells on allogeneic NK cells. These findings may be relevant to the NK-mediated rejection effect in HLA-mismatched hematopoietic stem cell transplantation

  9. Both mRNA and protein levels of NKG2D, MICA (show MICA Proteins), MICB (show MICB Proteins) and ULBP were upregulated in six types of thymomas compared with those in atrophic thymus or proliferating thymus.

  10. GSK-3 undergoes inhibitory phosphorylation at regulatory serine residues by the engagement of NKG2D and 2B4 (show CD244 Proteins), either individually or in combination.

Mouse (Murine) Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1) interaction partners

  1. These results support the conclusion that svH1C mimics Neu5Ac-containing sequences and interacts with cell-surface receptor NKG2D, which contains a lectin-like domain

  2. These results indicate that, unlike in the pancreas, NKG2D-NKG2D ligand interaction does not play a critical role in obesity-induced inflammation in the adipose tissue.

  3. The results show that NK cells and the NKG2D receptor play a role in control of lymphomas, and that selection of NKG2D-ligand (MULT1 (show ULBP1 Proteins)) loss mutants provides a mechanism for tumor escape.

  4. these data support a novel role for NKG2D expression by CD8 (show CD8A Proteins)(+) T cells during allogeneic HSCT, which could be potentially therapeutically exploited to separate GVHD from GVT effects.

  5. NKG2D and NKG2DL are involved in allergen-induced activation of dendritic epidermal T cells and the NKG2D/NKG2DL pathway might be a potential target for treatment of contact hypersensitivity.

  6. Viral infection of cultured cells increased RAE-1 (show RAE1 Proteins) expression, resulting in enhanced NK cell-mediated killing through NKG2D recognition.

  7. Activation through the NKG2D receptor leads to the differential activation of the NF-kappaB (show NFKB1 Proteins) signaling pathway and potentially enhances the anti-tumor and anti-viral functions of effector CD8 (show CD8A Proteins)(+) T cells.

  8. Desiccating stress-induced chemokine (show CCL1 Proteins) expression in the epithelium is dependent on upregulation of NKG2D/RAE-1 (show RAE1 Proteins) and release of IFN-gamma (show IFNG Proteins) in experimental dry eye.

  9. Highly target-specific liver NKT (show CTSL1 Proteins) cells selectively remove activated hepatic stellate cells through an NKG2D-Rae1 (show RAE1 Proteins) interaction to ameliorate liver fibrosis after IL-30 treatment.

  10. a protective role of NKG2D-activated natural killer cells in coxsackievirus B3 myocarditis leading to an effective virus clearance

Pig (Porcine) Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1) interaction partners

  1. The effect of Bacillus cereus on the stress response of enterocytes, including the expression of NKG2D, is reported.

Rhesus Monkey Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1) interaction partners

  1. Determined expressions of NKG2D in decidual natural killer cells in patients having spontaneous abortions.

Killer Cell Lectin-Like Receptor Subfamily K, Member 1 (KLRK1) Protein Profile

Protein Summary

Natural killer (NK) cells are lymphocytes that can mediate lysis of certain tumor cells and virus-infected cells without previous activation. They can also regulate specific humoral and cell-mediated immunity. NK cells preferentially express several calcium-dependent (C-type) lectins, which have been implicated in the regulation of NK cell function. The NKG2 gene family is located within the NK complex, a region that contains several C-type lectin genes preferentially expressed in NK cells. This gene encodes a member of the NKG2 family. The encoded transmembrane protein is characterized by a type II membrane orientation (has an extracellular C terminus) and the presence of a C-type lectin domain. It binds to a diverse family of ligands that include MHC class I chain-related A and B proteins and UL-16 binding proteins, where ligand-receptor interactions can result in the activation of NK and T cells. The surface expression of these ligands is important for the recognition of stressed cells by the immune system, and thus this protein and its ligands are therapeutic targets for the treatment of immune diseases and cancers. Read-through transcription exists between this gene and the upstream KLRC4 (killer cell lectin-like receptor subfamily C, member 4) family member in the same cluster.

Gene names and symbols associated with KLRK1

  • killer cell lectin-like receptor subfamily K, member 1 (KLRK1)
  • NKG2-D type II integral membrane protein-like (LOC100398970)
  • killer cell lectin-like receptor subfamily K, member 1 (Klrk1)
  • NKG2D protein (NKG2D)
  • CD314 protein
  • D6H12S2489E protein
  • D12S2489E protein
  • KLR protein
  • KLRK1 protein
  • NKG2-D protein
  • Nkg2d protein
  • Nkrp2 protein

Protein level used designations for KLRK1

killer cell lectin-like receptor subfamily K, member 1 , NKG2-D type II integral membrane protein-like , NK cell receptor D , NKG2-D type II integral membrane protein , NKG2-D-activating NK receptor , natural killer cell group 2D , NK lectin-like receptor , NKLLR , NKR-P2, ortholog of human NKG2D , killer cell lectin-like receptor subfamily K member 1 , NKG2-D activating NK receptor

GENE ID SPECIES
611355 Canis lupus familiaris
100126736 Papio anubis
100398970 Callithrix jacchus
22914 Homo sapiens
27007 Mus musculus
24934 Rattus norvegicus
396737 Sus scrofa
450153 Pan troglodytes
574240 Macaca mulatta
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