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anti-Kinase Suppressor of Ras 1 (KSR1) Antibodies

Location-regulated scaffolding protein connecting MEK to RAF. Additionally we are shipping Kinase Suppressor of Ras 1 Kits (8) and Kinase Suppressor of Ras 1 Proteins (7) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
KSR1 16706 Q61097
KSR1 360573  
KSR1 8844 Q8IVT5
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Top anti-Kinase Suppressor of Ras 1 Antibodies at antibodies-online.com

Showing 10 out of 99 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Mouse Rabbit Un-conjugated WB Mouse Ksr1 Antibody (C-term) (ABIN658071) western blot analysis in mouse NIH-3T3 cell line lysates (35 µg/lane). This demonstrates the Ksr1 antibody detected the Ksr1 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated EIA, IHC (p), WB 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC (p), WB Western blot analysis of anti-KSR1 Pab (ABIN392257) in A375 cell lysate. KSR1 (arrow) was detected using purified polyclonal antibody. Secondary HRP-anti-rabbit was used for signal visualization with chemiluminescence. Formalin-fixed and paraffin-embedded human cancer tissue reacted with the primary antibody, which was peroxidase-conjugated to the secondary antibody, followed by AEC staining. BC = breast carcinoma. HC = hepatocarcinoma 400 μL Log in to see 10 to 11 Days
$324.50
Details
Mouse Mouse Un-conjugated IF, WB Western blot analysis of KSR-1 on a RSV-3T3 lysate. Lane 1: 1:500, lane 2: 1:1000, lane 3: 1:2000 dilution of the anti- KSR-1 antibody. 50 μg Log in to see 5 to 6 Days
$205.42
Details
Human Rabbit Un-conjugated EIA, WB Western blot analysis of anti-KSR1 Pab in T47D cell line lysate. KSR1(arrow) was detected using the purified Pab. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IHC, ELISA, WB Western blot analysis of extracts from HepG2 cells, using KSR (Phospho-Ser392) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain, using KSR (Phospho-Ser392) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated WB Western blot analysis of anti-KSR1 Pab in T47D cell line lysate. KSR1(arrow) was detected using the purified polyclonal antibody. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IF, IHC, ELISA, WB Western blot analysis of extracts from NIH-3T3 cells, treated with PDGF 50ng/ml 20', using KSR (Ab-392) Antibody. The lane on the right is treated with the synthesized peptide. Immunohistochemistry analysis of paraffin-embedded human brain tissue, using KSR (Ab-392) Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated IF, IHC (p), ELISA, WB 100 μL Log in to see 8 to 10 Days
$478.50
Details
Human Rabbit Un-conjugated IF (p), IHC (p), WB Formalin-fixed and paraffin embedded rat brain labeled with Anti KSR1 Polyclonal Antibody, Unconjugated (ABIN700645) at 1:200 followed by conjugation to the secondary antibody and DAB staining 100 μL Log in to see 3 to 7 Days
$269.50
Details

KSR1 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Kinase Suppressor of Ras 1 Antibodies

  1. Mouse (Murine) Monoclonal KSR1 Primary Antibody for IF, WB - ABIN968599 : Michaud, Therrien, Cacace, Edsall, Spiegel, Rubin, Morrison: KSR stimulates Raf-1 activity in a kinase-independent manner. in Proceedings of the National Academy of Sciences of the United States of America 1998 (PubMed)
    Show all 4 references for ABIN968599

  2. Mouse (Murine) Polyclonal KSR1 Primary Antibody for WB - ABIN658071 : Razidlo, Johnson, Stoeger, Cowan, Bessho, Lewis: KSR1 is required for cell cycle reinitiation following DNA damage. in The Journal of biological chemistry 2009 (PubMed)

  3. Human Polyclonal KSR1 Primary Antibody for EIA, IHC (p) - ABIN360141 : Cantrell: Phosphoinositide 3-kinase signalling pathways. in Journal of cell science 2001 (PubMed)

  4. Human Polyclonal KSR1 Primary Antibody for IHC (p), WB - ABIN392257 : Blume-Jensen, Hunter: Oncogenic kinase signalling. in Nature 2001 (PubMed)

More Antibodies against Kinase Suppressor of Ras 1 Interaction Partners

Fruit Fly (Drosophila melanogaster) Kinase Suppressor of Ras 1 (KSR1) interaction partners

  1. the atypical C1 domain, the CC-SAM (show TTN Antibodies) domain is required to target KSR-1 to the plasma membrane.

  2. KSR is a scaffold required for activation of the ERK/MAPK (show MAPK1 Antibodies) module.

  3. Review discusses the possibility that KSR, a RAF (show ARAF Antibodies)-like protein, does not solely act as a scaffold, but directly induces RAF (show RAF1 Antibodies) catalytic function by a kinase-independent mechanism apparently shared by RAF (show RAF1 Antibodies)-like proteins.

Mouse (Murine) Kinase Suppressor of Ras 1 (KSR1) interaction partners

  1. Data show that caveolin-1 is necessary for optimal KSR1-dependent ERK activation by growth factors and oncogenic Ras.

  2. propose that phosphorylation of Tyr (show TYR Antibodies)(728) may regulate the transition between the scaffolding and the catalytic function of KSR1 serving as a control point used to fine-tune cellular responses

  3. Data indicate that phosphorylation of BRAF (show BRAF Antibodies) by AMPK (show PRKAA1 Antibodies) disrupts its association with KSR1.

  4. Despite its role in mTORC1 activation, KSR1 is not required in vivo for mTOR (show FRAP1 Antibodies)-dependent T cell differentiation.

  5. Ksr1 plays a dispensable role in lipopolysaccharide (LPS (show TLR4 Antibodies))-induced ERK (show EPHB2 Antibodies) activation in alveolar macrophages and does not contribute to the development of acute lung injury in the LPS (show TLR4 Antibodies) model.

  6. the atypical C1 domain, the CC-SAM (show TTN Antibodies) domain is required to target KSR-1 to the plasma membrane.

  7. The loss of Ksr1 inhibits Ras/Mapk (show MAPK1 Antibodies) pathway signaling leading to increased Myc (show MYC Antibodies)-induced B-cell apoptosis, and this results in reduced B-cell transformation and lymphoma development.

  8. a model whereby MARK2 (show MARK2 Antibodies) negatively regulates insulin (show INS Antibodies) sensitivity in peripheral tissue through inhibition of KSR1

  9. Genetic disruption of KSR1 results in striking reductions in kit-ligand (show KITLG Antibodies)-mediated proliferation & degranulation and impacts the biochemical activation of p21 (show D4S234E Antibodies)-activated kinase.

  10. Data suggest that feedback phosphorylation of KSR1 prevents excessive ERK1/2 (show MAPK1/3 Antibodies) signaling in the postsynaptic compartment and thus contributes to maintaining physiological levels of synaptic excitability.

Human Kinase Suppressor of Ras 1 (KSR1) interaction partners

  1. the relative mRNA copy values of KSR1, ERK1 (show MAPK3 Antibodies) and ERK2 (show MAPK1 Antibodies) in the cancer tissues were 2.43 +/- 0.49, 2.10 +/- 0.44 and 3.65 +/- 0.94..EGb 761 enhanced the chemotherapy sensitivity through suppression of the KSR1-mediated ERK1/2 (show MAPK1/3 Antibodies) pathway in gastric cancer

  2. KSR1 rs2241906 variants may predict survival in patients with advanced ERalpha (show ESR1 Antibodies)+ BC treated with adjuvant TAM (show CCNA1 Antibodies).

  3. KSR1 is coordinately regulated with Notch (show NOTCH1 Antibodies) signaling and oxidative phosphorylation in papillary thyroid cancer.

  4. KSR1 stabilizes BRCA1 by reducing BRCA1 ubiquitination, inhibits tumor growth through BRCA1, and regulates BRCA1 stability via elevated BARD1 (show BARD1 Antibodies) abundance and increased BRCA1-BARD1 (show BARD1 Antibodies) interaction

  5. Data show that caveolin-1 is necessary for optimal KSR1-dependent ERK activation by growth factors and oncogenic Ras.

  6. Data indicate that phosphorylation of BRAF (show BRAF Antibodies) by AMPK (show PRKAA1 Antibodies) disrupts its association with KSR1.

  7. Our findings integrate KSR1 into a network involving DBC1 (show DBC1 Antibodies) and SIRT1 (show SIRT1 Antibodies), which results in the regulation of p53 (show TP53 Antibodies) acetylation and its transcriptional activity.

  8. Elevated levels of phosphorylated KSR were detected in the nuclear fractions.

  9. the atypical C1 domain, the CC-SAM (show TTN Antibodies) domain is required to target KSR-1 to the plasma membrane.

  10. VRK2A can form a high molecular size complex with both MEK1 (show MAP2K1 Antibodies) and KSR1; the KSR1 complex assembled and retained by VRK2A in the endoplasmic reticulum can have a modulatory effect on the signal mediated by MAPK (show MAPK1 Antibodies),locally affecting the magnitude of its responses

Kinase Suppressor of Ras 1 (KSR1) Antigen Profile

Protein Summary

Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity.

Gene names and symbols associated with KSR1

  • kinase suppressor of ras 1 (KSR1) antibody
  • kinase suppressor of ras (ksr) antibody
  • kinase suppressor of ras 1 (Ksr1) antibody
  • AW492498 antibody
  • B-KSR1 antibody
  • CG2899 antibody
  • D11Bhm183e antibody
  • D11Bhm184e antibody
  • dKsr antibody
  • Dmel\\CG2899 antibody
  • EK3-1 antibody
  • hb antibody
  • Ksr antibody
  • Ksr-1 antibody
  • l(3)j5E2 antibody
  • RSU2 antibody
  • SR3-1 antibody

Protein level used designations for KSR1

CG2899-PA , kinase suppressor of Ras85D , ksr-PA , suppressor of Ras1 3-1 , kinase suppressor of Ras 1 , mKSR1 , protein Hb

GENE ID SPECIES
100071912 Equus caballus
40660 Drosophila melanogaster
16706 Mus musculus
360573 Rattus norvegicus
8844 Homo sapiens
427839 Gallus gallus
610451 Canis lupus familiaris
100511282 Sus scrofa
100138565 Bos taurus
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