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anti-Kinase Suppressor of Ras 2 (KSR2) Antibodies

Location-regulated scaffold connecting MEK to RAF. Additionally we are shipping Kinase Suppressor of Ras 2 Proteins (6) and Kinase Suppressor of Ras 2 Kits (5) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
KSR2 283455 Q6VAB6
KSR2 333050  
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Top anti-Kinase Suppressor of Ras 2 Antibodies at antibodies-online.com

Showing 10 out of 74 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated EIA, IHC (p), WB KSR2 Antibody (C-term) flow cytometric analysis of MCF-7 cells (right histogram) compared to a negative control cell (left histogram).FITC-conjugated goat-anti-rabbit secondary antibodies were used for the analysis. KSR2 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of KSR2 Antibody (C-term) for immunohistochemistry. Clinical relevance has not been evaluated. 0.4 mL Log in to see 6 to 8 Days
$390.50
Details
Human Rabbit Un-conjugated IF, ELISA, WB Western blot analysis of extracts from 293 cells, using KSR2 Antibody. The lane on the right is treated with the synthesized peptide. Immunofluorescence analysis of HeLa cells, using KSR2 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Mouse Un-conjugated RNAi, ELISA, WB Western blot analysis of KSR2 over-expressed 293 cell line, cotransfected with KSR2 Validated Chimera RNAi (Lane 2) or non-transfected control (Lane 1). Blot probed with KSR2 monoclonal antibody (M08) clone 1G4. GAPDH ( 36.1 kDa ) used as specificity and loading control. Detection limit for recombinant GST tagged KSR2 is approximately 0.03ng/ml as a capture antibody. 100 μg Log in to see 9 Days
$430.00
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (35.9 KDa) . 50 μL Log in to see 9 Days
$298.57
Details
Human Rabbit Un-conjugated FACS, IHC (p), WB KSR2 Antibody (C-term) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining.This data demonstrates the use of KSR2 Antibody (C-term) for immunohistochemistry.  Clinical relevance has not been evaluated. KSR2 Antibody (C-term)  western blot analysis in 293,K562,HepG2,Hela cell line lysates (35ug/lane).This demonstrates the KSR2 antibody detected the KSR2 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated WB Mouse Ksr2 Antibody (C-term) (ABIN658555) western blot analysis in human normal Uterus cell line lysates (35 µg/lane). This demonstrates the Ksr2 antibody detected the Ksr2 protein (arrow). 400 μL Log in to see 10 to 11 Days
$324.50
Details
Human Rabbit Un-conjugated IF, IHC (p), WB Human Kidney: Formalin-Fixed, Paraffin-Embedded (FFPE) 50 μL Log in to see 8 to 10 Days
$451.00
Details
Human Rabbit Un-conjugated IF, ELISA, WB 100 μL Log in to see 8 to 10 Days
$478.50
Details
Human Rabbit Un-conjugated EIA, IF, IHC (p), WB Immunohistochemistry analysis of KSR2 in human brain tissue (Formalin-fixed, Paraffin-embedded) using Kinase suppressor of Ras 2 antibody . Western blot analysis of KSR2 in extracts from 293 cells using Kinase suppressor of Ras 2 antibody . 0.1 mg Log in to see 6 to 8 Days
$390.50
Details
Human Mouse Un-conjugated IF, WB Immunofluorescence of monoclonal antibody to KSR2 on HeLa cell (antibody concentration 10 µg/mL). KSR2 monoclonal antibody (M02), clone 6C9 Western Blot analysis of KSR2 expression in A-431. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details

KSR2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
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Top referenced anti-Kinase Suppressor of Ras 2 Antibodies

  1. Human Polyclonal KSR2 Primary Antibody for EIA, IHC (p) - ABIN953078 : Liu, Channavajhala, Rao, Moutsatsos, Wu, Zhang, Lin, Qiu: Proteomic characterization of the dynamic KSR-2 interactome, a signaling scaffold complex in MAPK pathway. in Biochimica et biophysica acta 2009 (PubMed)
    Show all 2 references for ABIN953078

  2. Human Monoclonal KSR2 Primary Antibody for RNAi, ELISA - ABIN567007 : Costanzo-Garvey, Pfluger, Dougherty, Stock, Boehm, Chaika, Fernandez, Fisher, Kortum, Hong, Jun, Ko, Schreiner, Volle, Treece, Swift, Winer, Chen, Wu, Leon, Shaw, McNeish, Kim, Morrison, Tschöp, Lewis: KSR2 is an essential regulator of AMP kinase, energy expenditure, and insulin sensitivity. in Cell metabolism 2009 (PubMed)
    Show all 2 references for ABIN567007

  3. Human Polyclonal KSR2 Primary Antibody for ELISA, WB - ABIN566999 : Jia, Souchelnytskyi: Kinase suppressor of Ras 2 is involved in regulation of cell proliferation and is up-regulated in human invasive ductal carcinomas of breast. in Experimental oncology 2011 (PubMed)
    Show all 2 references for ABIN566999

  4. Human Polyclonal KSR2 Primary Antibody for IF, ELISA - ABIN1533965 : Scherer, Muzny, Buhay, Chen, Cree, Ding, Dugan-Rocha, Gill, Gunaratne, Harris, Hawes, Hernandez, Hodgson, Hume, Jackson, Khan, Kovar-Smith, Lewis, Lozado, Metzker, Milosavljevic, Miner, Montgomery et al.: The finished DNA sequence of human chromosome 12. ... in Nature 2006 (PubMed)

More Antibodies against Kinase Suppressor of Ras 2 Interaction Partners

Human Kinase Suppressor of Ras 2 (KSR2) interaction partners

  1. KSR2 (show CNKSR2 Antibodies) deficiency affects stromal interaction molecule 1 (STIM1 (show STIM1 Antibodies))/ORAI1 (show ORAI1 Antibodies) puncta formation, which is correlated with cytoskeleton disorganization.

  2. Study explored the role of KSR2 (show CNKSR2 Antibodies) in humans by sequencing 2,101 individuals with severe early-onset obesity and identified multiple rare variants in KSR2 (show CNKSR2 Antibodies) that disrupt signaling through the Raf (show RAF1 Antibodies)-MEKERK pathway and impair cellular fatty acid oxidation and glucose oxidation in transfected cells.

  3. study demonstrated that miR (show MLXIP Antibodies)-31 upregulated IL-2 (show IL2 Antibodies) expression via reduction of its up-stream kinase suppressor, KSR2 (show CNKSR2 Antibodies), and is a component of T cell activation

  4. The involvement of KSR2 (show CNKSR2 Antibodies) in regulation of cell proliferation was predicted by a KSR2 (show CNKSR2 Antibodies)-centered network analysis.

  5. KSR (show KSR1 Antibodies) interacts with a regulatory Raf (show RAF1 Antibodies) molecule in cis (show CISH Antibodies) to induce a conformational switch of MEK (show MAP2K1 Antibodies), facilitating MEK's phosphorylation by a separate catalytic Raf (show RAF1 Antibodies) molecule in trans

  6. Oncoprotein Cot1 represses kinase suppressors of Ras1/2 and 1,25-dihydroxyvitamin D3-induced differentiation of human acute myeloid leukemia (show BCL11A Antibodies) cells.

  7. hKSR-2, a new member of the KSR (show KSR1 Antibodies) family, negatively regulates Cot (show MAP3K8 Antibodies)-mediated MAP kinase (show MAPK1 Antibodies) and NF-kappaB (show NFKB1 Antibodies) pathway signaling

  8. We find that while hKSR-2 blocks MEKK3 (show MAP3K3 Antibodies) activation, it has little to no effect on other members of the MAP3K family, including MEKK4 (show MAP3K4 Antibodies), TAK1 (show MAP3K7 Antibodies), and Ras-Raf (show RAF1 Antibodies), suggesting that its effects are selective.

  9. These results demonstrate that kinase suppressor of Ras 2 is a direct target of 1,25-dihydroxyvitamin D(3)in HL60 cells, and is required for optimal monocytic differentiation.

  10. KSR-2 (show CNKSR2 Antibodies) may act as a scaffold protein (show HOMER1 Antibodies) similar as KSR-1 (show KSR1 Antibodies) to mediate the MAPK (show MAPK1 Antibodies) core (RAF (show RAF1 Antibodies)-MEK (show MAP2K1 Antibodies)-ERK (show EPHB2 Antibodies)) signaling but with a distinct RAF (show RAF1 Antibodies) isoform specificity; KSR-2 (show CNKSR2 Antibodies) may only mediate the A-RAF (show ARAF Antibodies) signaling while KSR-1 (show KSR1 Antibodies) transduces signals only from c-RAF (show RAF1 Antibodies).

Mouse (Murine) Kinase Suppressor of Ras 2 (KSR2) interaction partners

  1. KSR2 (show CNKSR2 Antibodies) deficiency affects stromal interaction molecule 1 (STIM1 (show STIM1 Antibodies))/ORAI1 (show TMEM132A Antibodies) puncta formation, which is correlated with cytoskeleton disorganization.

  2. KSR2 (show CNKSR2 Antibodies) is essential to tumor cell energy homeostasis and critical to the integration of mitogenic and metabolic signaling pathways

  3. The metabolic phenotype of KSR2 (show CNKSR2 Antibodies) heterozygous (KSR2 (show CNKSR2 Antibodies)(+/minus;)) and KSR2 (show CNKSR2 Antibodies)(-/-) mice suggests that human KSR2 (show CNKSR2 Antibodies) variants may contribute to a similar phenotype linked to human chromosome 12q24

  4. KSR2 (show CNKSR2 Antibodies) regulates AMPK (show PRKAA1 Antibodies)-dependent glucose uptake and fatty acid oxidation in mouse embryonic fibroblasts and glycolysis in a neuronal cell line.

  5. The protein phosphatase calcineurin (show PPP3CA Antibodies) selectively interacts with KSR2 (show CNKSR2 Antibodies) and KSR2 (show CNKSR2 Antibodies) uniquely contributes to Ca2 (show CA2 Antibodies)+-mediated ERK (show EPHB2 Antibodies) signaling.

Kinase Suppressor of Ras 2 (KSR2) Antigen Profile

Protein Summary

Location-regulated scaffold connecting MEK to RAF. Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.

Gene names and symbols associated with KSR2

  • kinase suppressor of ras 2 (KSR2) antibody
  • kinase suppressor of ras 2 (Ksr2) antibody

Protein level used designations for KSR2

kinase suppressor of Ras 2

GENE ID SPECIES
283455 Homo sapiens
333050 Mus musculus
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