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Kinase Suppressor of Ras 2 (KSR2) ELISA Kits

Location-regulated scaffold connecting MEK to RAF. Additionally we are shipping Kinase Suppressor of Ras 2 Antibodies (73) and Kinase Suppressor of Ras 2 Proteins (6) and many more products for this protein.

list all ELISA KIts Gene Name GeneID UniProt
KSR2 283455 Q6VAB6
KSR2 333050  
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Top Kinase Suppressor of Ras 2 ELISA Kits at antibodies-online.com

Showing 3 out of 5 products:

Catalog No. Reactivity Sensitivity Range Quantity Supplier Delivery Price Details
Human
96 Tests Log in to see 6 Days
$528.57
Details
Mouse
0.156-10 ng/mL 96 Tests Log in to see 11 to 13 Days
$875.60
Details
Human
78-5000 pg/mL 96 Tests Log in to see 11 to 13 Days
$875.60
Details

More ELISA Kits for Kinase Suppressor of Ras 2 Interaction Partners

Human Kinase Suppressor of Ras 2 (KSR2) interaction partners

  1. KSR2 (show CNKSR2 ELISA Kits) deficiency affects stromal interaction molecule 1 (STIM1 (show STIM1 ELISA Kits))/ORAI1 (show ORAI1 ELISA Kits) puncta formation, which is correlated with cytoskeleton disorganization.

  2. Study explored the role of KSR2 (show CNKSR2 ELISA Kits) in humans by sequencing 2,101 individuals with severe early-onset obesity and identified multiple rare variants in KSR2 (show CNKSR2 ELISA Kits) that disrupt signaling through the Raf (show RAF1 ELISA Kits)-MEKERK pathway and impair cellular fatty acid oxidation and glucose oxidation in transfected cells.

  3. study demonstrated that miR (show MLXIP ELISA Kits)-31 upregulated IL-2 (show IL2 ELISA Kits) expression via reduction of its up-stream kinase suppressor, KSR2 (show CNKSR2 ELISA Kits), and is a component of T cell activation

  4. The involvement of KSR2 (show CNKSR2 ELISA Kits) in regulation of cell proliferation was predicted by a KSR2 (show CNKSR2 ELISA Kits)-centered network analysis.

  5. KSR (show KSR1 ELISA Kits) interacts with a regulatory Raf (show RAF1 ELISA Kits) molecule in cis (show CISH ELISA Kits) to induce a conformational switch of MEK (show MAP2K1 ELISA Kits), facilitating MEK's phosphorylation by a separate catalytic Raf (show RAF1 ELISA Kits) molecule in trans

  6. Oncoprotein Cot1 represses kinase suppressors of Ras1/2 and 1,25-dihydroxyvitamin D3-induced differentiation of human acute myeloid leukemia (show BCL11A ELISA Kits) cells.

  7. hKSR-2, a new member of the KSR (show KSR1 ELISA Kits) family, negatively regulates Cot (show MAP3K8 ELISA Kits)-mediated MAP kinase (show MAPK1 ELISA Kits) and NF-kappaB (show NFKB1 ELISA Kits) pathway signaling

  8. We find that while hKSR-2 blocks MEKK3 (show MAP3K3 ELISA Kits) activation, it has little to no effect on other members of the MAP3K family, including MEKK4 (show MAP3K4 ELISA Kits), TAK1 (show MAP3K7 ELISA Kits), and Ras-Raf (show RAF1 ELISA Kits), suggesting that its effects are selective.

  9. These results demonstrate that kinase suppressor of Ras 2 is a direct target of 1,25-dihydroxyvitamin D(3)in HL60 cells, and is required for optimal monocytic differentiation.

  10. KSR-2 (show CNKSR2 ELISA Kits) may act as a scaffold protein (show HOMER1 ELISA Kits) similar as KSR-1 (show KSR1 ELISA Kits) to mediate the MAPK (show MAPK1 ELISA Kits) core (RAF (show RAF1 ELISA Kits)-MEK (show MAP2K1 ELISA Kits)-ERK (show EPHB2 ELISA Kits)) signaling but with a distinct RAF (show RAF1 ELISA Kits) isoform specificity; KSR-2 (show CNKSR2 ELISA Kits) may only mediate the A-RAF (show ARAF ELISA Kits) signaling while KSR-1 (show KSR1 ELISA Kits) transduces signals only from c-RAF (show RAF1 ELISA Kits).

Mouse (Murine) Kinase Suppressor of Ras 2 (KSR2) interaction partners

  1. KSR2 (show CNKSR2 ELISA Kits) deficiency affects stromal interaction molecule 1 (STIM1 (show STIM1 ELISA Kits))/ORAI1 (show TMEM132A ELISA Kits) puncta formation, which is correlated with cytoskeleton disorganization.

  2. KSR2 (show CNKSR2 ELISA Kits) is essential to tumor cell energy homeostasis and critical to the integration of mitogenic and metabolic signaling pathways

  3. The metabolic phenotype of KSR2 (show CNKSR2 ELISA Kits) heterozygous (KSR2 (show CNKSR2 ELISA Kits)(+/minus;)) and KSR2 (show CNKSR2 ELISA Kits)(-/-) mice suggests that human KSR2 (show CNKSR2 ELISA Kits) variants may contribute to a similar phenotype linked to human chromosome 12q24

  4. KSR2 (show CNKSR2 ELISA Kits) regulates AMPK (show PRKAA1 ELISA Kits)-dependent glucose uptake and fatty acid oxidation in mouse embryonic fibroblasts and glycolysis in a neuronal cell line.

  5. The protein phosphatase calcineurin (show PPP3CA ELISA Kits) selectively interacts with KSR2 (show CNKSR2 ELISA Kits) and KSR2 (show CNKSR2 ELISA Kits) uniquely contributes to Ca2 (show CA2 ELISA Kits)+-mediated ERK (show EPHB2 ELISA Kits) signaling.

Kinase Suppressor of Ras 2 (KSR2) Antigen Profile

Antigen Summary

Location-regulated scaffold connecting MEK to RAF. Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production.

Gene names and symbols associated with KSR2

  • kinase suppressor of ras 2 (KSR2) antibody
  • kinase suppressor of ras 2 (Ksr2) antibody

Protein level used designations for KSR2

kinase suppressor of Ras 2

GENE ID SPECIES
283455 Homo sapiens
333050 Mus musculus
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