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KIF11 encodes a motor protein that belongs to the kinesin-like protein family. Additionally we are shipping KIF11 Kits (5) and KIF11 Proteins (4) and many more products for this protein.
Showing 10 out of 94 products:
Human Polyclonal KIF11 Primary Antibody for BCA - ABIN2666149
Lee, Choi, Gyuris, Brent, Moore: Two classes of proteins dependent on either the presence or absence of thyroid hormone for interaction with the thyroid hormone receptor. in Molecular endocrinology (Baltimore, Md.) 1995
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Human Monoclonal KIF11 Primary Antibody for IF, WB - ABIN968406
Blangy, Lane, dHérin, Harper, Kress, Nigg: Phosphorylation by p34cdc2 regulates spindle association of human Eg5, a kinesin-related motor essential for bipolar spindle formation in vivo. in Cell 1996
Show all 2 references for ABIN968406
Human Polyclonal KIF11 Primary Antibody for IF, IHC - ABIN1532702
Deloukas, Earthrowl, Grafham, Rubenfield, French, Steward, Sims, Jones, Searle, Scott, Howe, Hunt, Andrews, Gilbert, Swarbreck, Ashurst, Taylor, Battles, Bird, Ainscough, Almeida, Ashwell, Ambrose et al.: The DNA sequence and comparative analysis of human chromosome 10. ... in Nature 2004
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Human Monoclonal KIF11 Primary Antibody for IP, WB - ABIN1449288
Brown: Sphingolipid organization in biomembranes: what physical studies of model membranes reveal. in Journal of cell science 1998
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Human Polyclonal KIF11 Primary Antibody for EIA, FACS - ABIN953071
Tcherniuk, van Lis, Kozielski, Skoufias: Mutations in the human kinesin Eg5 that confer resistance to monastrol and S-trityl-L-cysteine in tumor derived cell lines. in Biochemical pharmacology 2010
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Human Polyclonal KIF11 Primary Antibody for FACS, IHC (p) - ABIN653041
Parke, Wojcik, Kim, Worthylake: ATP hydrolysis in Eg5 kinesin involves a catalytic two-water mechanism. in The Journal of biological chemistry 2010
Human Monoclonal KIF11 Primary Antibody for IF, IP - ABIN1449287
Le Guellec, Paris, Couturier, Roghi, Philippe: Cloning by differential screening of a Xenopus cDNA that encodes a kinesin-related protein. in Molecular and cellular biology 1991
Data show that kinesin spindle protein Eg5 inhibitor LY2523355 has broad target-mediated anticancer activity in vitro and in vivo.
Data show there was no significant change in Eg5 protein inhibitor treatment.
the levels and distribution of TPX2 are likely to be determinants of when and where kinesin-5 acts in neurons.
Targeting KIF11 also hit the other arm of the "go or grow" cell fate decision by reducing glioma cell invasion.
Identification of mutations in 8.3% patients suggests KIF11 mutations as a common cause of familial exudative vitreoretinopathy (FEVR (show NDP Antibodies)).
This report, therefore, further expands the clinical and molecular spectrum of KIF11-associated microcephaly.
Data show that kinesin spindle protein (KSP) inhibition sensitized chronic myeloid leukemia (CML) cells to imatinib-induced apoptosis.
All inherited cases, and 50% of sporadic cases of MCLMR are due to germline KIF11 mutations. It is possible that mosaic KIF11 mutations cause the remainder of sporadic case
Dimeric, but not monomeric, Eg5 was differentially inhibited by full-length and truncated TPX2 (show TPX2 Antibodies), demonstrating that dimerization or residues in the neck region are important for the interaction of TPX2 (show TPX2 Antibodies) with Eg5.
This identified a heterozygous 2-base pair deletion (Thr65 del 2 base pair AT) in exon 2 that, to our knowledge, has not been previously reported.
Data suggest that poleward transport of TPX2, which requires dynein and Eg5, down-regulates its microtubule nucleating activity near kinetochores and links microtubules to dynein for incorporation into the spindle.
Data suggest that amyloid-beta (here, Abeta 1-42) induces acute and chronic synaptic dysfunction in part through inhibition of Eg5 (kinesin-5) in hippocampal neurons.
Disruption of the in vivo interaction of KIF11 with ZBP1 (show ZBP1 Antibodies) delocalizes beta-actin (show ACTB Antibodies) mRNA and affects cell migration.
These results suggest that 4-(N-(2-(N-acetylcysteine-S-yl) acetyl) amino)-4'- (N-(2-(N-(triphenylmethyl)amino)acetyl)amino)azobenzene could be used as photochromic inhibitor of Eg5 to achieve photocontrol of living cells.
incorporation of photochromic molecules into the key region of loop L5 facilitates the photocontrol of the function of kinesin Eg5.
Finally, when kinesin spindle protein (KSP) siRNA was encapsulated in lipid nanoparticles containing a modest amount of PEG (show PAEP Antibodies), the proliferation of endothelial cells was inhibited due to the efficient knock down of KSP mRNA.
These results show that intratumoral electro-transfer of siRNA is feasible and kinesin spindle protein (KSP)-specific siRNA may provide a novel strategy for therapeutic intervention.
observations explain the poleward accumulation of Eg5 in early mitosis and its redistribution in anaphase. Inhibition of dynein blocked Eg5 movement on microtubules, whereas depletion of the Eg5-binding protein TPX2 (show DAZL Antibodies) resulted in end-directed Eg5 movement.
Observations further support the conclusion that Eg5 is essential for cell division early in mouse development.
Results indicate that Eg5 overexpression disrupts the unique balance of forces associated with normal spindle assembly and function, and thereby leads to the development of spindle defects, genetic instability, and tumors.
Eg5 is essential during early mouse development and cannot be compensated by another molecular motor (show MYO1B Antibodies).
This gene encodes a motor protein that belongs to the kinesin-like protein family. Members of this protein family are known to be involved in various kinds of spindle dynamics. The function of this gene product includes chromosome positioning, centrosome separation and establishing a bipolar spindle during cell mitosis.
TR-interacting protein 5
, kinesin-like protein 1
, kinesin-like protein KIF11
, kinesin-like spindle protein HKSP
, kinesin-related motor protein Eg5
, thyroid receptor-interacting protein 5
, kinesin 11
, kinesin-like 1