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KIF14 is a member of the kinesin superfamily of microtubule-associated motors (see MIM 148760) that play important roles in intracellular transport and cell division (Nakagawa et al., 1997 [PubMed 9275178]).[supplied by OMIM, Mar 2008].. Additionally we are shipping KIF14 Kits (3) and and many more products for this protein.
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analysis of epigenetic regulation of KIF14 overexpression in ovarian cancer
Kinesin-14 blocks microtubule nucleation in yeast and reveal that this inhibition is countered by the kinesin-5 protein, Cut7.[Cut7, Pkl1]
High-grade serous ovarian cancer cells may depend on KIF14 for in vitro proliferation.
Mutations in KIF14 identified as a novel cause of an autosomal recessive lethal fetal ciliopathy phenotype.
critical role for KIF14 in the tumorigenic potential of triple-negative breast cancer
High KIF14 expression is associated with hepatocellular carcinoma.
KIF14 knockdown downregulates the expression of Skp2 and Cks1 (show CKS1B Antibodies), leading to accumulation of p27Kip1 (show CDKN1B Antibodies).
KIF14 inhibits tumor growth and cancer metastasis in lung adenocarcinoma.
Data indicate that KIF14 and TLN1 (show TLN1 Antibodies) loss-of-function significantly enhanced chemosensitivity in four triple-negative breast cancer (TNBC) cell lines.
Suppression of KIF14 not only decreases cancer cell migration but also induces apoptosis of cells.
The ADP-bound form of the KIF14 motor domain reveals a dramatically opened ATP-binding pocket.
Kif14 mutation causes severe brain malformation and hypomyelination.
KIF14 is a member of the kinesin superfamily of microtubule-associated motors (see MIM 148760) that play important roles in intracellular transport and cell division (Nakagawa et al., 1997
kinesin family member 14
, kinesin-like protein KIF14
, kinesin-like protein KIF14-like
, N-3 kinesin