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KIF14 is a member of the kinesin superfamily of microtubule-associated motors (see MIM 148760) that play important roles in intracellular transport and cell division (Nakagawa et al., 1997 [PubMed 9275178]).[supplied by OMIM, Mar 2008].. Additionally we are shipping KIF14 Kits (4) and and many more products for this protein.
Showing 10 out of 32 products:
Human Polyclonal KIF14 Primary Antibody for ICC, IF - ABIN151721
Corson, Huang, Tsao, Gallie: KIF14 is a candidate oncogene in the 1q minimal region of genomic gain in multiple cancers. in Oncogene 2005
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Human Polyclonal KIF14 Primary Antibody for IP, WB - ABIN151710
Abiatari, DeOliveira, Kerkadze, Schwager, Esposito, Giese, Huber, Bergman, Abdollahi, Friess, Kleeff: Consensus transcriptome signature of perineural invasion in pancreatic carcinoma. in Molecular cancer therapeutics 2009
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Studied overexpression of KIF14 which showed the tight correlation between KIF14 upregulation and inferior clinical outcome in medulloblastoma (MB), suggesting KIF14 is a potential negative prognostic marker in MB. Transient, siRNAs-mediated downregulation of KIF14 suppressed cell proliferation and induced apoptosis in two MB cell lines.
study suggests that KIF14 may serve as a predictor of poor survival and a novel prognostic biomarker of chemoresistance to paclitaxel treatment in cervical cancer.
analysis of epigenetic regulation of KIF14 overexpression in ovarian cancer
Kinesin-14 blocks microtubule nucleation in yeast and reveal that this inhibition is countered by the kinesin-5 protein, Cut7.[Cut7, Pkl1]
High-grade serous ovarian cancer cells may depend on KIF14 for in vitro proliferation.
Mutations in KIF14 identified as a novel cause of an autosomal recessive lethal fetal ciliopathy phenotype.
critical role for KIF14 in the tumorigenic potential of triple-negative breast cancer
High KIF14 expression is associated with hepatocellular carcinoma.
KIF14 knockdown downregulates the expression of Skp2 and Cks1 (show CKS1B Antibodies), leading to accumulation of p27Kip1 (show CDKN1B Antibodies).
KIF14 inhibits tumor growth and cancer metastasis in lung adenocarcinoma.
Data provide the first evidence that Kif14 can promote tumor formation in susceptible cells in vivo
The ADP-bound form of the KIF14 motor domain reveals a dramatically opened ATP-binding pocket.
Kif14 mutation causes severe brain malformation and hypomyelination.
KIF14 is a member of the kinesin superfamily of microtubule-associated motors (see MIM 148760) that play important roles in intracellular transport and cell division (Nakagawa et al., 1997
kinesin family member 14
, kinesin-like protein KIF14
, kinesin-like protein KIF14-like
, N-3 kinesin