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mouse homolog associates with microtubulew and appears to play a role in mitosis in fibroblasts and in migration in developing neurons [RGD, Feb 2006].. Additionally we are shipping KIF15 Proteins (3) and many more products for this protein.
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Cow (Bovine) Polyclonal KIF15 Primary Antibody for WB - ABIN2778199
Stelzl, Worm, Lalowski, Haenig, Brembeck, Goehler, Stroedicke, Zenkner, Schoenherr, Koeppen, Timm, Mintzlaff, Abraham, Bock, Kietzmann, Goedde, Toksöz, Droege, Krobitsch, Korn, Birchmeier, Lehrach et al.: A human protein-protein interaction network: a resource for annotating the proteome. ... in Cell 2005
When intersecting microtubules are parallel, Kif15 motors can drive (biased) parallel sliding because the motor simultaneously steps on both microtubules that it cross-links.
Eg5, Kif15, and dynein work together to build a bipolar spindle and reveal an important role for antagonistic motors in chromosome segregation.
Although Kif15 contains ADP in the catalytic site, its motor-domain structure was captured in the ;ATP-like' configuration, with the neck linker docked to the catalytic core.
By examining Kif15 activity in two cellular contexts, it was found that Kif15 bound to kinetochore fibers antagonizes centrosome separation while Kif15 bound to nonkinetochore MTs (show TIMM8A Antibodies) mediates centrosome separation.
Pole separation depends on Hklp2/Kif15, an otherwise dispensable plus end-directed spindle motor and results in spindles with two centrosomal poles.
Kif15 can replace all essential functions of Eg5 (show KIF11 Antibodies) in bipolar spindle assembly.
Hklp2 participates in the assembly and stabilization of the bipolar spindle.
Kif15 opposes the capacity of other motors to generate independent microtubule movements within key regions of developing neurons.
mouse homolog associates with microtubulew and appears to play a role in mitosis in fibroblasts and in migration in developing neurons
kinesin-like protein 2-A
, kinesin-like protein KIF15-A
, kinesin family member 15
, kinesin-like protein KIF15-B
, kinesin-like protein 2-B
, kinesin-like protein KIF15-like
, kinesin-like 7
, kinesin-like protein 2
, kinesin-like protein 7
, kinesin-like protein KIF15
, serologically defined breast cancer antigen NY-BR-62
, N-10 kinesin
, kinesin 15