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Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B along microtubules.. Additionally we are shipping KIF17 Antibodies (23) and many more products for this protein.
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Expression of KIF17 in schizophrenic postmortem brains was significantly lower than controls. Both genotypic distribution and allelic frequency of rs2296225 polymorphism were significantly different between the chronic schizophrenia subjects and controls.
although EB1 (show MAPRE2 Proteins) and KIF17-Tail may coordinate KIF17 catalytic activity, our data reveal a novel and direct role for KIF17 in regulating MT dynamics.
This study suggested that disruption of KIF17, although rare, could result in a schizophrenia phenotype and emphasize the possible involvement of rare de novo mutations in this disorder.
Depletion of KIF17 from cells growing in three-dimensional matrices results in aberrant epithelial cysts that fail to generate a single central lumen and to polarize apical markers.
Data show that the homodimeric kinesin-2 (show KIF2A Proteins) motor KIF17 is kept in an inactive state in the absence of cargo, and define two molecular mechanisms that contribute to autoinhibition of KIF17.
The intense placental expression of KIFC1 (show KIFC1 Proteins) in syncytiotrophoblast and KIF17 in vascular endothelium suggests that both proteins might be important in a cargo-transport system. KIFC1 (show KIFC1 Proteins) and KIF17 expression are increased of both in preeclamptia and diabetes.
KIF17b serves as a molecular motor (show MYO1E Proteins) component of a TB-RBP (show TSN Proteins)-mouse ribonucleoprotein complex transporting a group of specific CREM (show CREM Proteins)-regulated mRNAs.
Our findings have uncovered a hitherto unknown effector of Rab23 (show RAB23 Proteins) and demonstrate how Rab23 (show RAB23 Proteins) could mediate the transport of Kif17 to the primary cilium
D1-type dopaminergic receptors are delivered to cilia by a mechanism requiring the receptor cytoplasmic tail, the intraflagellar transport complex-B (IFT-B), and ciliary kinesin KIF17. This targeting mechanism critically depends on Rab23 (show RAB23 Proteins).
KIF17 contributed to the development of bone cancer pain in the spinal cord through NR2B (show GRIN2B Proteins) transport and mLin10 may also play a role in pain development.
findings indicated that CaMKII (show CAMK2G Proteins)-mediated KIF17/NR2B (show GRIN2B Proteins) trafficking may contribute to bone cancer pain, and inhibition of CaMKII (show CAMK2G Proteins) may be a useful alternative or adjunct therapy for relieving cancer pain
prenatal stress significantly decreased the hippocampal KIF17 and NR2B (show GRIN2B Proteins) level in offspring at postnatal stages of 3 weeks and 9 weeks, which may be related to deficits of spatial cognition caused by prenatal stress.
The results of this study suggested that phosphorylation-based regulation of NMDA receptor transport is critical for learning and memory in vivo and regulate by kif17.
This study demonistrated that KIF17 is fundamental for memory and learning via differential support of synaptic NR2A (show GRIN2A Proteins)/2B levels.
NRF-1 (show NRF1 Proteins) co-regulates oxidative enzymes that generate energy and neurochemicals that consume energy related to glutamatergic neurotransmission, such as KIF17, NR1 (show GRIN1 Proteins), and NR2B (show GRIN2B Proteins).
KIF17 contributes to neuronal events required for learning and memory by trafficking fundamental N-methyl-d-aspartate-type glutamate (show GRIN1 Proteins) receptor, NR2A (show GRIN2A Proteins).
ACT selectively associates with KIF17b, a kinesin highly expressed in male germ cells; The ACT-KIF17b interaction is restricted to specific stages of spermatogenesis and directly determines the intracellular localization of ACT [KIF17b]
Transports vesicles containing N-methyl-D-aspartate (NMDA) receptor 2B along microtubules.
KIF17 variant protein
, KIF3-related motor protein
, kinesin-like protein KIF17
, N-4 kinesin
, kinesin 17