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microtubule-based molecular motor which is responsible for transporting membrane-bound organelles [RGD, Feb 2006].. Additionally we are shipping KIF1C Antibodies (39) and many more products for this protein.
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Rab6A binding to KIF1C's motor domain represents an entirely new mode of regulation for a kinesin motor, and likely has important consequences for KIF1C's cellular functions.
KIF1C translocation to the cell periphery intensifies and KIF1C accumulates both in the proximity of peripheral microtubules that show enrichment for the plus-tip-associated proteins CLASPs and around podosomes.
Microtubule acetylation influences the subcellular distribution of vesicles associated with the kinesin KIF1C, as well as their directionality, velocity and run length.
Nonsense and missense mutations in the KIF1C gene associated with hereditary spastic paraparesis and cerebellar dysfunction.
Identification of KIF1C as an hereditary spastic paraplegia gene supports the key role of intracellular trafficking processes in the pathogenesis of hereditary axonopathies.
findings show that the microtubule motor Kif1C contributes to persistent cell migration primarily through stabilization of an extended cell rearKif1C-mediated transport of alpha5beta1-integrins is required for the proper maturation of trailing focal adhesions and resistance to tail retraction
Data show that 4-oxo-4-HPR inhibited tubulin polymerization and modulated gene expression of spindle aberration associated genes Kif 1C, Kif 2A, Eg5, Tara, tankyrase-1, centractin, and TOGp.
Hairpin RNA-based depletion of KIF1C resulted in decreased podosome dynamics and ultimately in podosome deficiency.
by utilizing a forward genetic approach, we identified kinesin family member 1C (Kif1c) as a positional candidate for Orch3 and, using a transgenic approach, demonstrated that Kif1c is Orch3
Kif1c was excluded as a candidate anthrax susceptibility gene
More than 90% of early endocytic vesicles associated with Kifc1 (show KIFC1 Proteins) also contained Kif5B, and inhibition of Kifc1 (show KIFC1 Proteins) with antibody resulted in enhancement of plus-end-directed motility.
microtubule-based molecular motor which is responsible for transporting membrane-bound organelles
kinesin family member 1C
, kinesin-like protein KIF1C-like
, kinesin-like protein KIF1C
, N-3 kinsin
, kinesin 1C
, kinesin superfamily protein 1C
, lethal factor toxin susceptibility 1
, kinesin-like protein KIF1D