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Kinesin Light Chain 1 Proteins (KLC1)

Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. Additionally we are shipping Kinesin Light Chain 1 Antibodies (62) and Kinesin Light Chain 1 Kits (2) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KLC1 3831 Q07866
KLC1 171041 P37285
KLC1 16593  
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Top Kinesin Light Chain 1 Proteins at antibodies-online.com

Showing 3 out of 3 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$3,604.33
Details

KLC1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human

Rat (Rattus)

Mouse (Murine)

More Proteins for Kinesin Light Chain 1 (KLC1) Interaction Partners

Human Kinesin Light Chain 1 (KLC1) interaction partners

  1. BNIP-2 (show BNIP2 Proteins) is a kinesin-1 adapter involved in vesicular transportation in the cytoplasm and that association with cargos depends on interaction of the CRAL-TRIO (show TRIO Proteins) domain with membrane phosphatidylserine.

  2. The G allele and GG genotype of KLC1 rs8702 were significantly over-represented among cataract patients, as compared to healthy controls, and were associated with an odds ratio for cataract development.

  3. Dnm1L (show DNM1L Proteins) interacts with KLC1 through the tetratricopeptide repeat domains.

  4. Microtubule-bound kinesin-1 and kinesin-3 motor domains were visualized at multiple steps in their ATPase cycles--including their nucleotide-free states--at approximately 7 A resolution using cryo-electron microscopy.

  5. Studies indicate that FEZ1 (fasciculation and elongation protein zeta 1 (show LZTS1 Proteins)), SCOCO (short coiled-coil protein (show SCOC Proteins)) and kinesins (kinesin heavy chain (show KIF5A Proteins)) are involved in biological transport process.

  6. The expression levels of KLC1 variant E in brain and lymphocytes were significantly higher in Alzheimer's disease patients.

  7. study provides evidence that the combined effect of three variants within the KLC1 gene may predispose to age-related cataract.

  8. For the binding of cargos shared by KLC1, we propose a different site located within the groove but not involving N343.

  9. Data suggest that KLC1 is required for normal neural differentiation, ensuring proper metabolism of AD-associated molecules APP (show APP Proteins) and Tau and for proliferation of neural precursors (NPs (show NPS Proteins)).

  10. Phosphorylation of KLC1 at serine 460 modulates binding and trafficking of calsyntenin-1 (show CLSTN1 Proteins).

Mouse (Murine) Kinesin Light Chain 1 (KLC1) interaction partners

  1. In old mice, lack of KLC1 results in retinal pigment epithelium pathogenesis that was strikingly comparable to aspects of age-related macular degeneration.

  2. Alcalpha is efficiently processed in part to minimize the inappropriate peripheral retention of kinesin-1

  3. A small peptide sequence is sufficient for initiating kinesin-1 activation through part of TPR (show GRID2 Proteins) region of KLC1

  4. Data show that amyloid precursor protein (APP (show APP Proteins)) levels are well-correlated with the amount of the light chain of kinesin-1 (KLC1).

  5. KLC1-ALK is the first novel oncogenic fusion identified using only formalin-fixed paraffin-embedded tissue tissues

  6. Phosphorylation of KLC1 at serine 460 modulates binding and trafficking of calsyntenin-1 (show CLSTN1 Proteins).

  7. changes in the phosphorylation state of KLC1 at Ser517/520 are unlikely to affect motor function.

  8. An essential role of mNUDC for anterograde transport of dynein and dynactin by kinesin-1.

  9. Impairment of anterograde transport by knockdown of KIF5B or KLC1 delayed stress-granule dissolution.

  10. analysis of a novel protein-protein interaction between KLC1 and JLP that involves leucine zipper-like domains

Kinesin Light Chain 1 (KLC1) Protein Profile

Protein Summary

Conventional kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the kinesin light chain family. It associates with kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, kinesin light chains function as adapter molecules and not motors per se. Although previously named 'kinesin 2', this gene is not a member of the kinesin-2 / kinesin heavy chain subfamily of kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos\; however, the full-length nature and/or biological validity of most of these variants have not been determined.

Gene names and symbols associated with Kinesin Light Chain 1 Proteins (KLC1)

  • kinesin light chain 1b (klc1b)
  • kinesin light chain 1 (KLC1)
  • kinesin light chain 1a (klc1a)
  • kinesin light chain 1 (klc1)
  • kinesin light chain 1 (Klc1)
  • AI874768 protein
  • kinesin-II protein
  • KLC protein
  • klc1 protein
  • Klc2 protein
  • KNS2 protein
  • KNS2A protein
  • wu:fj17e04 protein
  • zgc:55666 protein
  • zgc:66299 protein
  • zgc:77660 protein

Protein level used designations for Kinesin Light Chain 1 Proteins (KLC1)

kinesin 2 , kinesin light chain 1 , kinesin light chain 2 , kinesin light chain 4 , kinesin 2 60/70kDa , kinesin ii , KLC 1 , medulloblastoma antigen MU-MB-2.50

GENE ID SPECIES
335499 Danio rerio
508999 Bos taurus
393928 Danio rerio
550001 Xenopus (Silurana) tropicalis
100016881 Monodelphis domestica
100075996 Ornithorhynchus anatinus
100380464 Salmo salar
100560020 Anolis carolinensis
3831 Homo sapiens
171041 Rattus norvegicus
16593 Mus musculus
423484 Gallus gallus
100173833 Pongo abelii
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