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Kinetochore-Localized Astrin/SPAG5 Binding Protein Proteins (KNSTRN)

Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase. Additionally we are shipping KNSTRN Antibodies (7) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KNSTRN 51944 Q9D9Z1
KNSTRN 90417 Q9Y448
KNSTRN 311325 Q6AXN6
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Top KNSTRN Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
HOST_Escherichia coli (E. coli) Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
HOST_Escherichia coli (E. coli) Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 29 to 34 Days
$4,331.68
Details
Yeast Rat His tag   1 mg Log in to see 56 to 66 Days
$2,834.33
Details
HOST_Human Human Un-conjugated   20 μg Log in to see 9 to 11 Days
$785.40
Details

KNSTRN Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human ,

Rat (Rattus)

More Proteins for Kinetochore-Localized Astrin/SPAG5 Binding Protein (KNSTRN) Interaction Partners

Human Kinetochore-Localized Astrin/SPAG5 Binding Protein (KNSTRN) interaction partners

  1. KNSTRN Mutation, a Cutaneous Squamous Carcinoma-Specific Mutation is associated with Solid Tumors and Leukemias.

  2. Molecular requirements for the inter-subunit interaction and kinetochore recruitment of SKAP and Astrin (show SPAG5 Proteins) have been reported.

  3. study reports presence of KNSTRN mutations in basal cell carcinomas (BCC); mutant KNSTRN disrupts sister chromatid cohesion and promotes genomic instability in functional assays; KNSTRN mutations in BCC appear to occur late in disease progression and are preferentially found in advanced tumors

  4. Mechanistically, the N-terminal of SKAP binds to EB1, and its C terminus binds to IQGAP1 in migrating cells.

  5. These findings suggest that SKAP promotes ultraviolet rays-induced cell apoptosis by negatively regulating the anti-apoptotic protein Prp19.

  6. Findings suggest a role for kinetochore protein KNSTRN mutagenesis in cutaneous squamous cell carcinomas (SCCs) development.

  7. SKAP constitutes a dynamic link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division.

  8. SKAP cooperates with CENP-E (show CENPE Proteins) to orchestrate dynamic kinetochore-microtubule interaction for faithful chromosome segregation.

  9. This paper identifies role of gene product of FLJ14502, named SKAP in the paper, in mitosis. SKAP promotes metaphase-to-anaphase transition by mediating seperase activation after spindle assembly checkpoint is satisfied in mitosis.

KNSTRN Protein Profile

Protein Summary

Essential component of the mitotic spindle required for normal chromosome segregation and progression into anaphase. Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture. The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments (By similarity).

Gene names and symbols associated with KNSTRN

  • kinetochore-localized astrin/SPAG5 binding (Knstrn)
  • kinetochore-localized astrin/SPAG5 binding protein (KNSTRN)
  • kinetochore-localized astrin/SPAG5 binding protein (Knstrn)
  • 1700025D04Rik protein
  • C15orf23 protein
  • D2Ertd750e protein
  • SKAP protein
  • TRAF4AF1 protein

Protein level used designations for KNSTRN

TRAF4 associated factor 1 homolog , TRAF4-associated factor 1 , kinastrin , kinetochore-localized astrin-binding protein , kinetochore-localized astrin/SPAG5-binding protein , putative TRAF4-associated factor 1 , small kinetochore-associated protein , TRAF4 associated factor 1 , small kinetochore associated protein , small kinetochore-associated protein, kinetochore-localized astrin-binding protein, TRAF4 associated factor 1

GENE ID SPECIES
51944 Mus musculus
90417 Homo sapiens
311325 Rattus norvegicus
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