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Transcription repressor that binds to the promoter of target genes and prevents their expression. Additionally we are shipping KLF17 Antibodies (51) and KLF17 Kits (11) and many more products for this protein.
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Data suggest that Neptune is a new member of hatching gland specifier and plays a physiological role in determination and specification of multiple lineages derived from the NPB region.
Suggest that KLF17 inhibits esophageal carcinoma development and may serve as a potential therapeutic target.
Enhanced KLF17 expression sensitizes ERalpha (show ESR1 Proteins)-positive breast cancer cells to endocrine therapy.KLF17-ERalpha (show ESR1 Proteins) interaction plays a potential role in inhibition of ERalpha (show ESR1 Proteins)-dependent breast cancer progression.
KLF17 empowers TGF-beta (show TGFB1 Proteins)/Smad (show SMAD1 Proteins) signaling by targeting Smad3 (show SMAD3 Proteins)-dependent pathway to suppress tumor growth and metastasis during cancer progression.
Tumor-suppressive p53 (show TP53 Proteins) signaling is critical for KLF17 to inhibit cancer metastasis in Non-small Cell Lung Cancer.
A small subset of Myoepithelial tumors harbor FUS (show FUS Proteins) rearrangements, two thirds of them being associated with KLF17 fusion.
In this review, we focus on the functions, roles, and regulatory networks of these five KLFs in HCC (show FAM126A Proteins), summarize key pathways, and propose areas for further investigation
The reduced expression of KLF17 promoted the motility and proliferation ability of TPC1 (show TPCN1 Proteins) cells by altering the expression of tight junction protein 1 (show TJP1 Proteins) and Snai1 (show SNAI1 Proteins), and activating the AKT (show AKT1 Proteins) pathway by upregulating inhibitor of DNA binding 1 (show ID1 Proteins).
mutant p53 (show TP53 Proteins) enhances cancer progression by inhibiting KLF17 expression in invasive breast carcinoma cells
The reduced expression of KLF17 protein in gastric cancer was correlated with tumor size, pN stage and lymphovascular invasion and was an independent predictor for poor survival in patients undergoing surgery for gastric cancer.
KLF17 might be one of the downstream signalling molecules of DJ-1 (show PARK7 Proteins).
ZFP393 functions as a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development
demonstrate that KLF17 expression is significantly downregulated in primary human breast cancer samples and that the combined expression pattern of KLF17 and Id1 (show ID1 Proteins) can serve as a potential biomarker for lymph node metastasis in breast cancer
Transcription repressor that binds to the promoter of target genes and prevents their expression. Acts as a negative regulator of epithelial-mesenchymal transition and metastasis in breast cancer. Specifically binds the 5'-CACCC-3' sequence in the promoter of ID1, a key metastasis regulator in breast cancer, and repress its expression. May be a germ cell-specific transcription factor that plays important roles in spermatid differentiation and oocyte development (By similarity).
Kruppel-like factor 17
, Kruppel-like transcription factor neptune
, novel kruppel-like factor family protein
, krueppel-like factor 17-like
, Krueppel-like factor 17
, novel zinc-finger protein
, zinc finger protein 393
, germ cell specific zinc finger protein
, germ cell-specific zinc finger protein