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The protein encoded by KLF11 is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. Additionally we are shipping KLF11 Antibodies (85) and KLF11 Kits (1) and many more products for this protein.
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Profibrotic gene expression was activated in a primary human peritoneal cell line in response to KLF11 short hairpin RNA and medroxyprogesterone acetate but not estradiol.
In endometrial-stromal fibroblasts, KLF11 recruited SIN3A (show SIN3A Proteins)/HDAC (histone deacetylase (show HDAC1 Proteins)), resulting in COL1A1 (show COL1A1 Proteins)-promoter deacetylation and repression
Results suggest a role for KLF11 in upregulating MAO-A (show MAOA Proteins) in depressive disorder and chronic social stress, suggesting that inhibition of the pathways regulated by this transcription factor may aid in the therapeutics of neuropsychiatric illnesses
The data suggest a relationship between promoter DNA methylation (show HELLS Proteins) and KLF11 gene expression in ovarian cancer tumorigenesis.
identified an evolutionarily conserved metabolic regulator, Kruppel-like factor 11 (KLF11), as a novel browning transcription factor in human adipocytes that is required for rosiglitazone-induced browning.
KLF11 repressed most endometrial CYP (show PPIG Proteins) enzymes
Levels of KLF11 are significantly increased in the postmortem prefrontal cortex of subjects with alcohol dependence compared to controls.
KLF11 regulates distinct gene networks.
KLF111 represses glycodelin-A (show PAEP Proteins) levels and influences its role in the ovarian endometrium.
KLF11 is a critical transcription factor in the function of mesenchymal cells and, specifically, as a negative regulator of collagen secretion.
Using a sterile peritonitis model, fibrosis selectively developed in Klf11-/- females. Fibrosis in these animals was almost completely abrogated by ovariectomy. Ovariectomized animals were selectively supplemented with estradiol, medroxyprogesterone acetate (MPA), or dihydrotestosterone; fibrosis was only observed in mice exposed to MPA.
TGFbeta (show TGFB1 Proteins) and KLF11 mediate critical, translationally relevant host and lesion-driven responses that enable establishment and progression of endometriosis.
Data show that the major phenotype given by the whole-body deletion of Kruppel-like factor 11 (Klf11) is not diabetes but increased insulin (show INS Proteins) sensitivity.
Loss of KLF11 expression is associated with hyperglycemia in Type 2 diabetes.
this study revealed a new role for the KLF11 gene in the mechanisms underlying the antinociceptive effects of chronic ethanol exposure
Taken together, our findings identify a novel anti-hypertrophic and anti-fibrotic role of KLF11, and KLF11 activator may serve as candidate drug for heart failure patients.
Overexpression of KLF11 in the livers of diabetic and obese mice activates the PPARalpha (show PPARA Proteins) signaling pathway, subsequently markedly improving the fatty liver phenotype. Knockdown of KLF11 increases hepatic triglycerides.
Data identify a novel pathogenic role for KLF11 in preventing de novo disease-associated fibrosis in endometriosis.
The protein encoded by this gene is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene.
Kruppel-like factor 11
, novel kruppel-like factor family protein
, krueppel-like factor 11-like
, Krueppel-like factor 11-like
, Krueppel-like factor 11
, TGFB-inducible early growth response protein 2
, transforming growth factor-beta-inducible early growth response protein 2
, TGFB inducible early growth response 2
, TGFB inducible early growth response 3
, TGFB-inducible early growth response protein 2b
, TGFB-inducible early growth response protein 3
, transforming growth factor-beta-inducible early growth response protein 3
, transcription factor CP2-like 2
, TGF-beta inducible early growth response protein 2