Kruppel-Like Factor 12 Proteins (KLF12)

Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. Additionally we are shipping KLF12 Antibodies (58) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
KLF12 11278 Q9Y4X4
KLF12 16597 O35738
Rat KLF12 KLF12 306110  
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Top KLF12 Proteins at antibodies-online.com

Showing 5 out of 6 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$5,442.50
Details
HOST_Escherichia coli (E. coli) Human His tag Validation with Western Blot 50 μg Log in to see 10 to 12 Days
$229.85
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HOST_Wheat germ Human GST tag 2 μg Log in to see 11 to 12 Days
$333.33
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HOST_Escherichia coli (E. coli) Human Un-conjugated   100 μg Log in to see 2 to 3 Days
$413.21
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KLF12 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , ,
,
Mouse (Murine)

More Proteins for Kruppel-Like Factor 12 (KLF12) Interaction Partners

Human Kruppel-Like Factor 12 (KLF12) interaction partners

  1. Data indicate Kruppel-like factor 12 protein (KLF12) as a metastasis-suppressor gene whose loss of function is associated with anoikis resistance through control of the cell cycle.

  2. KLF12 promotes tumor growth by directly activating early growth response protein 1 (EGR1 (show EGR1 Proteins)). The levels of KLF12 and EGR1 (show EGR1 Proteins) correlate synergistically with a poor prognosis. These results indicate that KLF12 likely plays an important role in CRC (show CALR Proteins) and could serve as a potential prognostic marker and therapeutic target.

  3. the overexpression of miR (show MLXIP Proteins)-141 augments anoikis resistance in ovarian cancer cells by targeting and repressing the expression of KLF12, which, in turn, competes for binding sites in the survivin (show BIRC5 Proteins) promoter with Sp1 (show PSG1 Proteins). The subsequent increase in survivin (show BIRC5 Proteins) then protects ovarian cancer cells against anoikis by blocking the intrinsic apoptotic activity.

  4. Data show Kruppel-like factor 12 (KLF12) impairs endometrial decidualization by transcriptionally repressing Nur77 (show NR4A1 Proteins) protein, and Nur77 (show NR4A1 Proteins) overexpression reverses the poor decidual response of endometrial stromal cells (hESCs) in recurrent implantation failure (RIF) patients.

  5. SLC29A1 (show SLC29A1 Proteins) rs760370 and KLF12 rs9543524 SNPs are associated with treatment induced thrombocytopenia in chronic hepatitis C patients treated with PEGIFN2b/ribavirin/combination.

  6. our results supported that miR (show MLXIP Proteins)-205 was a miR (show MLXIP Proteins) specific to basal-like breast carcinoma (BLBC). which functioned as tumor suppressor gene through directly targeting and negatively regulating proto-oncogene (show RAB1A Proteins) KLF12. miR (show MLXIP Proteins)-205 dysregulation was involved in invasion and apoptosis. miR (show MLXIP Proteins)-205 and KLF12 provided a potential diagnosis biomarker and therapeutic approach for BLBC.

  7. Overexpression of KLF12 is associated with gastric cancer.

  8. Elevated KLF12 expression was accompanied by decreased FOXO1 (show FOXO1 Proteins) expression in the endometria of patients with repeated implantation failure.

  9. overexpression of KLF12 in endometrial stromal cells significantly repressed the expression and secretion of decidualization biomarker genes and their products decidual prolactin (show PRL Proteins) and insulin-like growth factor binding protein-1 (show IGFBPI Proteins)

  10. The KLF12 rs1324913 A allele homozygous genotype is a possible predictor of Rheumatoid Arthritis.

Mouse (Murine) Kruppel-Like Factor 12 (KLF12) interaction partners

  1. KLF12 is involved in the maturation processes of collecting ducts after birth, and UT-A1 is a target gene of KLF12.

KLF12 Protein Profile

Protein Summary

Activator protein-2 alpha (AP-2 alpha) is a developmentally-regulated transcription factor and important regulator of gene expression during vertebrate development and carcinogenesis. The protein encoded by this gene is a member of the Kruppel-like zinc finger protein family and can repress expression of the AP-2 alpha gene by binding to a specific site in the AP-2 alpha gene promoter. Repression by the encoded protein requires binding with a corepressor, CtBP1. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with Kruppel-Like Factor 12 Proteins (KLF12)

  • Kruppel-like factor 12b (klf12b)
  • Kruppel-like factor 12 (KLF12)
  • Kruppel-like factor 12 (LOC100342041)
  • Kruppel-like factor 12 (Klf12)
  • Kruppel-like factor 12a (klf12a)
  • 2700063E05Rik protein
  • AI225908 protein
  • AI315654 protein
  • AP-2rep protein
  • AP2REP protein
  • B130052C06Rik protein
  • D530033K05Rik protein
  • fb02h07 protein
  • klf12 protein
  • wu:fb02h07 protein
  • zgc:77286 protein
  • zgc:171689 protein

Protein level used designations for Kruppel-Like Factor 12 Proteins (KLF12)

Krueppel-like factor 12 , Kruppel-like factor 12 , AP-2 repressor , AP-2rep transcription factor , KLF12 zinc finger transcriptional repressor , transcriptional repressor AP-2rep

GENE ID SPECIES
100126139 Danio rerio
100140477 Bos taurus
100342041 Oryctolagus cuniculus
11278 Homo sapiens
100174955 Sus scrofa
16597 Mus musculus
306110 Rattus norvegicus
798629 Danio rerio
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