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KLF6 encodes a member of the Kruppel-like family of transcription factors. Additionally we are shipping KLF6 Antibodies (48) and KLF6 Proteins (18) and many more products for this protein.
The study highlights the central role of myeloid KLF6 in promoting intestinal inflammation.
study identifies a new mechanism by which KLF6 regulates NF-kappaB (show NFKB1 ELISA Kits) signaling, and how this mechanism is circumvented in glioblastoma through KLF6 loss.
our results established the significance of activating the KLF6-E2F1 axis in aggressive primary metastatic clear cell renal cell carcinoma
KLF6 overexpression suppressed the xenograft tumor growth.
KLF6 and KLF15 (show KLF15 ELISA Kits) are targeted and suppressed in breast cancer cells by miR (show MLXIP ELISA Kits)-4262.
KLF6 acts as a tumor suppressor in CMM cells and miR (show MLXIP ELISA Kits)-4262 promotes the proliferation of CMM cells through KLF6-mediated EGFR (show EGFR ELISA Kits) inactivation and p21 (show CDKN1A ELISA Kits) upregulation.
These results suggest that KLF6 regulates MMP14 (show MMP14 ELISA Kits) transcription and is a critical player of the gene expression network triggered during endothelial repair.
KLF6 is a novel regulator of human villous trophoblast fusion.
KLF6 overexpression partially phenocopied chaetocin treatment in DDLPS cells and induced phenotypic changes that were consistent with adipocytic differentiation, suggesting that the effects of increased H3K9me3 may be mediated through KLF6
Study revealed that overexpression of miR (show MLXIP ELISA Kits)-101 inhibited the proliferation, cell migration, invasion, and promoted apoptosis of glioblastoma stem cells by directly targeting KLF6
KLF6-mediated activation of the human INSL3 (show INSL3 ELISA Kits) promoter required an intact KLF element as well as Leydig/Sertoli-enriched factors. KLF6 transcriptionally cooperates with NUR77 (show NR4A1 ELISA Kits) and SF1 (show SF1 ELISA Kits). our results identify KLF6 as a regulator of human INSL3 (show INSL3 ELISA Kits) transcription.
we identified novel transcriptional targets of KLF6 in HCC cells including VAV3, a known activator of the RAC1 small GTPase. Indeed, RAC1 activity is increased in KLF6-knockdown cells in a VAV3-dependent manner, and knockdown of either RAC1 or VAV3 impairs HCC cell migration. Together, our data demonstrate a novel function for KLF6 in constraining HCC dissemination through the regulation of a VAV3-RAC1 signaling axis.
Klf6 as required for developmental central nervous system myelination.Klf6 promotes oligodendrocyte differentiation and viability.
observations reveal that KLF6 repress BCL6 (show BCL6 ELISA Kits) to enhance macrophage inflammatory gene expression and function.
present studies on the cardiac function of KLF6 show a new mechanism whereby cardiomyocytes regulate cardiac fibrosis through transcriptional control of the extracellular matrix factor thrombospondin 4 (show THBS4 ELISA Kits)
downregulates expression and secretion of granulocyte macrophage colony-stimulating factor (show CSF2 ELISA Kits)
KLF6-dependent regulation of the cytochrome c (show CYCS ELISA Kits) oxidase assembly gene is critical for maintaining mitochondrial function and preventing podocyte apoptosis.
findings provide novel evidence highlighting KLF6 function in response to malignant transformation, suggesting the relevance of KLF6 in controlling cell proliferation and hindering tumorigenesis
KLF6 is required for optimal LPS (show TLR4 ELISA Kits)-induced pro-inflammatory gene expression, acting cooperatively with NF-kappaB (show NFKB1 ELISA Kits)
Klf6a promotes hematopoietic stem and progenitor cell maintenance through Ccl25b-Ccr7 (show CCR7 ELISA Kits) chemokine (show CCL1 ELISA Kits) signaling.
In the spinal cord, klf7 (show KLF7 ELISA Kits)- and klf6a-expressing cells are found in both the dorsal and ventral horns. Numerous sensory structures (e.g. auditory, lateral line, olfactory and visual) and several motor nuclei (e.g. oculomotor, trigeminal, and vagal motor nuclei) contain klf7 (show KLF7 ELISA Kits)- and/or klf6a-expressing cells
copeb/Klf6 is essential for the development of endoderm-derived organs
This gene encodes a member of the Kruppel-like family of transcription factors. The zinc finger protein is a transcriptional activator, and functions as a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for this gene, some of which are implicated in carcinogenesis.
Kruppel-like factor 6
, core promoter element binding protein
, Krueppel-like factor 6
, krueppel-like factor 6
, B-cell-derived protein 1
, GC-rich binding factor
, GC-rich sites-binding factor GBF
, Kruppel-like zinc finger protein Zf9
, core promoter element-binding protein
, proto-oncogene BCD1
, protooncogene B-cell derived 1
, suppression of tumorigenicity 12 (prostate)
, suppressor of tumorigenicity 12 protein
, transcription factor Zf9
, immediate early response, erythropoietin 1