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KCNIP1 encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Additionally we are shipping Kv Channel Interacting Protein 1 Proteins (5) and many more products for this protein.
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Chicken Polyclonal KCNIP1 Primary Antibody for IHC, WB - ABIN2776208
Pruunsild, Timmusk: Structure, alternative splicing, and expression of the human and mouse KCNIP gene family. in Genomics 2005
in the embryo, at the onset of neurogenesis Kcnip1 is the Ca(2 (show CA2 Antibodies))-dependent transcriptional repressor that controls the size of the neural plate.
These studies showed that a common copy number variation in KCNIP1 gene is a genetic predictor of atrial fibrillation risk possibly pointing to a functional pathway.
KCNIP1 from copy number variations study might function as a type 2 diabetes susceptibility gene whose dysregulation alters insulin (show INS Antibodies) production.
Protein aggregation due to nsSNP resulting in P56S VABP protein is associated with amyotrophic lateral sclerosis
V234I-VAPB (show VAPB Antibodies) induces ubiquitin aggregation followed by cell death; proposed that V234I-VAPB (show VAPB Antibodies) exhibits the characteristics of amyotrophic lateral sclerosis in spite of not having the typical aggregation property of different mutations in various neurodegenerative diseases
our findings suggest that KChIP1 interacts with Kv4.3 (show KCND3 Antibodies) in interneurons at the stratum lacunosum-moleculare/radiatum junction
Data show that KChIP1, KChIP2.1, and KChIP2.2 could form homo- as well as hetero-oligomers, and that this oligomerization did not perturb their interaction with Kv4.2 (show KCND2 Antibodies) potassium channel (show KCNAB2 Antibodies).
X-ray crystallographic and small-angle X-ray scattering data that show that the KChIP1-Kv4.3 (show KCND3 Antibodies) N-terminal cytoplasmic domain complex is a cross-shaped octamer bearing two principal interaction sites.
These results reveal a new role for KChIP3 (show KCNIP3 Antibodies) in the regulation of calcium regulated secretion and also suggest that the functions of each of the KChIPs may be more specialized than previously appreciated.
EF-hands 3 and 4 of KChIP1 are functionally involved in a specific association with PS on the membrane
KChIP1 is a synaptic protein that regulates behavioral anxiety by modulating inhibitory synaptic transmission.
Differential expression of KCh1P1 splice variants can shape the function of Kv4.2 (show KCND2 Antibodies) channels involved in protection against back propagating action potentials in dendritic spines.
KChIP1 was expressed in a subpopulation of neurons widely distributed in brain and enriched in Purkinje cells of the cerebellum and in the reticular thalamic and medial habenular nuclei.
KChIP1 deletion showed increased susceptibility to anti-GABAergic convulsive drug pentylenetetrazole-induced seizure, indicating that KChIP1 might play pivotal roles in the GABAergic inhibitory system.
This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Alternative splicing results in multiple transcript variant encoding different isoforms.
Kv channel interacting protein 1
, A-type potassium channel modulatory protein 1
, Kv channel-interacting protein 1
, potassium channel interacting protein 1
, vesicle APC-binding protein
, A-type potassium channel modulatory protein 1.2
, potassium channel-interacting protein 1