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Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Additionally we are shipping Kynureninase (L-Kynurenine Hydrolase) Proteins (17) and Kynureninase (L-Kynurenine Hydrolase) Kits (14) and many more products for this protein.
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Human Polyclonal KYNU Primary Antibody for IHC, IHC (p) - ABIN4329491
Guastella, Michelhaugh, Klinger, Kupsky, Polin, Muzik, Juhász, Mittal: Tryptophan PET Imaging of the Kynurenine Pathway in Patient-Derived Xenograft Models of Glioblastoma. in Molecular imaging 2016
Show all 2 Pubmed References
Human Polyclonal KYNU Primary Antibody for ELISA, WB - ABIN563893
Guillemin, Cullen, Lim, Smythe, Garner, Kapoor, Takikawa, Brew: Characterization of the kynurenine pathway in human neurons. in The Journal of neuroscience : the official journal of the Society for Neuroscience 2007
Cow (Bovine) Polyclonal KYNU Primary Antibody for IHC, WB - ABIN2782445
Suzuki, Yoshitomo-Nakagawa, Maruyama, Suyama, Sugano: Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. in Gene 1997
Our results suggest that tryptophan metabolism might dichotomously modulate immune responses, with KYNU as a switch between immunosuppressive versus inflammatory outcomes.
A rare variant at the KYNU gene is associated with essential hypertension in the Han Chinese population.
The Lys412Glu polymorphism of the KYNU gene in a hypertensive candidate chromosomal region is associated with essential hypertension in Han Chinese.
Levels of mRNA for IDO (show IDO1 Antibodies) (indoleamine 2,3-dioxygenase) and kynureninase, enzymes constituting the tryptophan degradation pathway, were found to be upregulated in the skin lesions of atopic dermatitis or psoriasis
Kynureninase is a pyridoxal-5'-phosphate (pyridoxal-P) dependent enzyme that catalyzes the cleavage of L-kynurenine and L-3-hydroxykynurenine into anthranilic and 3-hydroxyanthranilic acids, respectively. Kynureninase is involved in the biosynthesis of NAD cofactors from tryptophan through the kynurenine pathway. Alternative splicing results in multiple transcript variants.
, kynureninase (L-kynurenine hydrolase)
, L-kynurenine hydrolase