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The protein encoded by L1CAM is an axonal glycoprotein belonging to the immunoglobulin supergene family. Additionally we are shipping L1 Cell Adhesion Molecule Antibodies (274) and L1 Cell Adhesion Molecule Proteins (24) and many more products for this protein.
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L1CAM is a neuronal cell adhesion molecule (show NRCAM ELISA Kits) involved in the development of the nervous system and progression of malignancies. (Review)
Involvement of L1CAM in the regulation of activity of the canonical Wnt (show WNT2 ELISA Kits) pathway and expression of genes of class I melanoma-associated (show ZNF654 ELISA Kits) antigens in melanoma.
L1CAM was a significant independent prognosticator for disease-specific survival in endometrial carcinoma.
Report high frequency of L1CAM expression in high-risk endometrial cancers associated with mutant p53 (show TP53 ELISA Kits) expression.
L1CAM is frequently expressed in testicular germ cell tumors but not in normal testis.
Our results suggest that the overexpression of L1CAM may be related to several established markers of poor prognosis in breast cancer patients.
L1-CAM (show CALM1 ELISA Kits) and N-CAM (show NCAM1 ELISA Kits): From Adhesion Proteins to Pharmacological Targets
the CE7-epitope of L1-CAM (show CALM1 ELISA Kits) is a cell adhesion molecule (show MCAM ELISA Kits) aberrantly expressed in several cancers and may have a role in immunotherapy
novel missense variant in L1CAM was identified in two Caucasian families with mild-moderate intellectual disability without obvious L1 syndrome features
This study identified predicted pathogenic, hemizygous variants on chromosome X in disease genes L1CAM.
induced expression of L1CAM or PSA (show NPEPPS ELISA Kits)-NCAM (show NCAM1 ELISA Kits) in the iPSC-derived DA neurons cannot completely restore the neurite outgrowth potential that was reduced in these DA neurons as a consequence of epigenetic aberrations resulting from the iPSC reprogramming process.
Heterozygous L1CAM-deficient mice express an autism-like phenotype.
tumors in stressed animals demonstrated markedly enhanced expression of VEGFR-2 (show KDR ELISA Kits) and L1CAM mRNA as well as pERK (show EIF2AK3 ELISA Kits), MMP-2 (show MMP2 ELISA Kits) and MMP-9 (show MMP9 ELISA Kits) protein expression.
Function-triggering antibodies to the adhesion molecule (show NCAM1 ELISA Kits) L1 enhance recovery after injury of the adult mouse femoral nerve.
We suggest that L1 stimulates neuritogenesis by activating CK2alpha leading to decreased levels of PTEN and p53 (show TP53 ELISA Kits) via a novel, L1-triggered and CK2alpha-mediated signal transduction pathway.
a positive relationship between L1 and pPKD1 in both cultured cerebellar neurons and human cerebellar tissue, suggesting that L1 functions in the modulation of PKD1 (show PKD1 ELISA Kits) phosphorylation.
Myelin basic protein (show MBP ELISA Kits) cleaves cell adhesion molecule (show MCAM ELISA Kits) L1 and promotes neuritogenesis and cell survival.
These results demonstrate that L1 promotes neuronal differentiation from ESCs (show NR2E3 ELISA Kits) through the L1-mediated enhancement of FUT9 (show FUT9 ELISA Kits) and ST3Gal4 (show ST3GAL4 ELISA Kits) expression.
L1 stimulation triggers sumoylation and cleavage of L1, thus generating the L1-70 fragment which is cleaved by cathepsin E (show CTSE ELISA Kits)
the neurite outgrowth promoted by Neural Cell Adhesion Molecule L1 was strongly inhibited by siRNA against FGF21 (show FGF21 ELISA Kits) gene or a treatment of cells with FGFR (show FGFR2 ELISA Kits) inhibitor
The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause three X-linked neurological syndromes known by the acronym CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of a neuron-specific exon is thought to be functionally relevant.
neural cell adhesion molecule L1
, antigen identified by monoclonal antibody R1
, N-CAM L1
, nerve-growth factor-inducible large external glycoprotein
, neuron-glia cell adhesion molecule (Ng-CAM)
, neuronal-glial cell adhesion molecule